(Q27658042)

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Insights into cleavage specificity from the crystal structure of foot-and-mouth disease virus 3C protease complexed with a peptide substrate

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scholarly article

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Insights into cleavage specificity from the crystal structure of foot-and-mouth disease virus 3C protease complexed with a peptide substrate (English)

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crystal structure

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foot-and-mouth disease

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based on heuristic

inferred from title

foot-and-mouth disease virus

object named as

foot-and-mouth disease virus

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based on heuristic

inferred from title

8

object named as

Stephen Curry

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Trevor R Sweeney

object named as

Trevor R Sweeney

3

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Patricia A Zunszain

object named as

Patricia A Zunszain

1

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Robin Leatherbarrow

object named as

Robin J Leatherbarrow

7

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Graham J. Belsham

object named as

Graham J Belsham

6

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author name string

Stephen R Knox

2

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Jingjie Yang

4

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Núria Roqué-Rosell

5

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language of work or name

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publication date

15 January 2010

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Journal of Molecular Biology

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395

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2

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375-89

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Structure of human rhinovirus 3C protease reveals a trypsin-like polypeptide fold, RNA-binding site, and means for cleaving precursor polyprotein

1 reference

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Cleavage of translation initiation factor 4AI (eIF4AI) but not eIF4AII by foot-and-mouth disease virus 3C protease: identification of the eIF4AI cleavage site

1 reference

https://pubmed.ncbi.nlm.nih.gov/19883658

12 December 2020

based on heuristic

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Identification of the active-site residues of the 3C proteinase of foot-and-mouth disease virus

1 reference

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Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds

1 reference

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Translation and replication of FMDV RNA.

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Control and eradication of foot-and-mouth disease

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Structural basis of substrate specificity in the serine proteases

1 reference

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Dynamics of picornavirus RNA replication within infected cells

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Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor. II. Crystallographic refinement at 1.9 A resolution.

1 reference

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Evidence for the role of His-142 of protein 1C in the acid-induced disassembly of foot-and-mouth disease virus capsids

1 reference

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Foot-and-mouth disease virus 3C protease: recent structural and functional insights into an antiviral target

1 reference

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The CCP4 suite: programs for protein crystallography

1 reference

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Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold

1 reference

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Version 1.2 of the Crystallography and NMR system

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Evaluation of automated RT-PCR to accelerate the laboratory diagnosis of foot-and-mouth disease virus.

1 reference

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Cleavage of small peptides in vitro by human rhinovirus 14 3C protease expressed in Escherichia coli

1 reference

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Refined X-ray crystallographic structure of the poliovirus 3C gene product

1 reference

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Serine protease mechanism and specificity

1 reference

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Crystallization of foot-and-mouth disease virus 3C protease: surface mutagenesis and a novel crystal-optimization strategy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19883658

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based on heuristic

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Picornaviral 3C cysteine proteinases have a fold similar to chymotrypsin-like serine proteinases

1 reference

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Structural basis for the substrate specificity of tobacco etch virus protease

1 reference

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A continuous assay for foot-and-mouth disease virus 3C protease activity

1 reference

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An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19883658

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

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Comparative genomics of foot-and-mouth disease virus

1 reference

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Structural analysis of foot-and-mouth disease virus 3C protease: a viable target for antiviral drugs?

1 reference

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Crystal and molecular structures of the complex of alpha-chymotrypsin with its inhibitor turkey ovomucoid third domain at 1.8 A resolution

1 reference

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Cleavage site analysis in picornaviral polyproteins: discovering cellular targets by neural networks

1 reference

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Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

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Role of RNA structure and RNA binding activity of foot-and-mouth disease virus 3C protein in VPg uridylylation and virus replication

1 reference

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Hepatitis A virus 3C proteinase substrate specificity

1 reference

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Crystal and molecular structure of the bovine α-chymotrypsin-eglin c complex at 2.0 Å resolution

1 reference

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Foot-and-mouth disease

1 reference

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Structural and mutagenic analysis of foot-and-mouth disease virus 3C protease reveals the role of the beta-ribbon in proteolysis

1 reference

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The structures of picornaviral proteinases.

1 reference

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NMR solution structures of the apo and peptide-inhibited human rhinovirus 3C protease (Serotype 14): structural and dynamic comparison

1 reference

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based on heuristic

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Structure of the trypsin-binding domain of Bowman-Birk type protease inhibitor and its interaction with trypsin

1 reference

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Structures of Two Coronavirus Main Proteases: Implications for Substrate Binding and Antiviral Drug Design

1 reference

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Crystal structure of an ecotin-collagenase complex suggests a model for recognition and cleavage of the collagen triple helix

1 reference

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Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes

1 reference

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Crystal structure of foot-and-mouth disease virus 3C protease. New insights into catalytic mechanism and cleavage specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19883658

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based on heuristic

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A consensus sequence for substrate hydrolysis by rhinovirus 3C proteinase

1 reference

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Phasercrystallographic software

1 reference

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Protein inhibitors of proteinases

1 reference

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Crystal structure of an inhibitor complex of the 3C proteinase from hepatitis A virus (HAV) and implications for the polyprotein processing in HAV

1 reference

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Dual modes of modification of hepatitis A virus 3C protease by a serine-derived beta-lactone: selective crystallization and formation of a functional catalytic triad in the active site

1 reference

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On the size of the active site in proteases. I. Papain

1 reference

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based on heuristic

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Substrate requirements of human rhinovirus 3C protease for peptide cleavage in vitro

1 reference

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Cleavage of synthetic peptides by purified poliovirus 3C proteinase

1 reference

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eMovie: a storyboard-based tool for making molecular movies

1 reference

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

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