(Q27667103)

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Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei

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scholarly article

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Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei (English)

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structural biology

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Burkholderia pseudomallei

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infectious disease

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based on heuristic

inferred from title

6

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Thomas E Edwards

object named as

Thomas E Edwards

4

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object named as

Peter J Myler

9

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10

object named as

Bart L Staker

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11

object named as

Lance J Stewart

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Darren W Begley

1

object named as

Darren W Begley

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Douglas J Davies

3

object named as

Douglas R Davies

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5

object named as

Jess T Leonard

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Janhavi Bhandari

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object named as

Janhavi Bhandari

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author name string

Robert C Hartley

2

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Courtney A Burris

7

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language of work or name

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inferred from title

publication date

July 2011

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Journal of Structural and Functional Genomics

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12

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2

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63-76

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MolProbity: all-atom structure validation for macromolecular crystallography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

20 March 2017

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

20 March 2017

The Role of Medical Structural Genomics in Discovering New Drugs for Infectious Diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

20 March 2017

Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography †

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

20 March 2017

Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

20 March 2017

Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

20 March 2017

Biological and chemical terrorism: strategic plan for preparedness and response - recommendations of the CDC strategic planning workgroup

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

20 March 2017

The Protein Data Bank

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

20 March 2017

Optimal description of a protein structure in terms of multiple groups undergoing TLS motion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

20 March 2017

Coot: model-building tools for molecular graphics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

20 March 2017

The CCP4 suite: programs for protein crystallography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

20 March 2017

Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

20 March 2017

Announcing the worldwide Protein Data Bank

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

20 March 2017

Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

20 March 2017

Management of melioidosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

20 March 2017

Biosynthesis of isoprenoids via the non-mevalonate pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

20 March 2017

Drugs for bad bugs: confronting the challenges of antibacterial discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

7 April 2017

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

7 April 2017

Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

7 April 2017

Discovering high-affinity ligands for proteins: SAR by NMR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

7 April 2017

Fragment screening of infectious disease targets in a structural genomics environment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

29 September 2017

Predicting the success of fragment screening by X-ray crystallography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

29 September 2017

Fragment-based discovery of novel thymidylate synthase leads by NMR screening and group epitope mapping

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

29 September 2017

Present and future therapeutic strategies for melioidosis and glanders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

29 September 2017

The Seattle Structural Genomics Center for Infectious Disease (SSGCID).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

29 September 2017

Targeted mutagenesis of Burkholderia thailandensis and Burkholderia pseudomallei through natural transformation of PCR fragments.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

29 September 2017

Privileged structures: a useful concept for the rational design of new lead drug candidates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

29 September 2017

Nuclear magnetic resonance fragment-based identification of novel FKBP12 inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

29 September 2017

The SeeDs approach: integrating fragments into drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

29 September 2017

Burkholderia mallei and Burkholderia pseudomallei as bioterrorism agents: national aspects of emergency preparedness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

29 September 2017

On sampling of fragment space

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

29 September 2017

A fragment-based approach for the discovery of isoform-specific p38alpha inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

29 September 2017

The non-mevalonate pathway of isoprenoid precursor biosynthesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

29 September 2017

A decade of fragment-based drug design: strategic advances and lessons learned

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

29 September 2017

Fragonomics: fragment-based drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

29 September 2017

A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

29 September 2017

NMR-based techniques in the hit identification and optimisation processes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

29 September 2017

Theory and applications of NMR-based screening in pharmaceutical research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

29 September 2017

Fragment-based lead discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

29 September 2017

Fosmidomycin for the treatment of malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

29 September 2017

NMR spectroscopy techniques for screening and identifying ligand binding to protein receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

29 September 2017

In vitro and in vivo synergy of fosmidomycin, a novel antimalarial drug, with clindamycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

29 September 2017

High-throughput crystallography for lead discovery in drug design.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

29 September 2017

Molecular complexity and its impact on the probability of finding leads for drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

29 September 2017

Discovering novel ligands for macromolecules using X-ray crystallographic screening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

29 September 2017

Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3123455

2 June 2018

Fragment-based lead discovery using X-ray crystallography.

1 reference

https://api.crossref.org/works/10.1007%2FS10969-011-9102-6

21 January 2018

Fosmidomycin for malaria

1 reference

https://api.crossref.org/works/10.1007%2FS10969-011-9102-6

21 January 2018

Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

1 reference

https://api.crossref.org/works/10.1007%2FS10969-011-9102-6

21 January 2018

The inter-ligand Overhauser effect: a powerful new NMR approach for mapping structural relationships of macromolecular ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/21359640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SAR by ILOEs: an NMR-based approach to reverse chemical genetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/21359640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multivalent drug design and inhibition of cholera toxin by specific and transient protein-ligand interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/21359640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://pubmed.ncbi.nlm.nih.gov/21359640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of Ligand Binding by Saturation Transfer Difference NMR Spectroscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21359640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10969-011-9102-6

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