(Q27667771)

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Structural basis of thrombin-mediated factor V activation: the Glu666-Glu672 sequence is critical for processing at the heavy chain-B domain junction

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21555742%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Structural basis of thrombin-mediated factor V activation: the Glu666-Glu672 sequence is critical for processing at the heavy chain-B domain junction (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21555742%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

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Erick Hernández-Carvajal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21555742%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Ricardo Gutiérrez Gallego

4

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31 January 2020

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Paul E Bock

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31 January 2020

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María Ángeles Corral-Rodríguez

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31 January 2020

Pablo Fuentes-Prior

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31 January 2020

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publication date

9 May 2011

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31 January 2020

number of pages

10

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31 January 2020

117

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31 January 2020

26

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31 January 2020

7164-7173

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31 January 2020

Crystal Structure of Thrombin Bound to the Uncleaved Extracellular Fragment of PAR1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

20 March 2017

Crystal structure of an RNA aptamer bound to thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

20 March 2017

Crystal Structure of a Biosynthetic Sulfo-hirudin Complexed to Thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

20 March 2017

Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

20 March 2017

Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

20 March 2017

Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

20 March 2017

Interaction of the factor XIII activation peptide with alpha -thrombin. Crystal structure of its enzyme-substrate analog complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

20 March 2017

Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

20 March 2017

Structure of the Ser195Ala mutant of human alpha--thrombin complexed with fibrinopeptide A(7--16): evidence for residual catalytic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

20 March 2017

Bovine thrombin complexed with an uncleavable analog of residues 7-19 of fibrinogen A alpha: geometry of the catalytic triad and interactions of the P1', P2', and P3' substrate residues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

20 March 2017

The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

20 March 2017

The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

20 March 2017

The structure of a complex of recombinant hirudin and human alpha-thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

20 March 2017

The coagulation cascade: initiation, maintenance, and regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

20 March 2017

NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

29 September 2017

Leech-derived thrombin inhibitors: from structures to mechanisms to clinical applications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

29 September 2017

Acidic residues C-terminal to the A2 domain facilitate thrombin-catalyzed activation of factor VIII.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

29 September 2017

The role of thrombin exosites I and II in the activation of human coagulation factor V.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

29 September 2017

Exosites in the substrate specificity of blood coagulation reactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

29 September 2017

Removal of B-domain sequences from factor V rather than specific proteolysis underlies the mechanism by which cofactor function is realized

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

29 September 2017

Crystal structure of the complex between thrombin and the central "E" region of fibrin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

29 September 2017

The sequence Glu1811-Lys1818 of human blood coagulation factor VIII comprises a binding site for activated factor IX.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

29 September 2017

Sulfation of tyrosine residues in coagulation factor V.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

29 September 2017

The interaction of thrombin with fibrinogen. A structural basis for its specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

29 September 2017

Role of the acidic hirudin-like COOH-terminal amino acid region of factor Va heavy chain in the enhanced function of prothrombinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

2 June 2018

The Contribution of Amino Acid Region Asp695-Tyr698 of Factor V to Procofactor Activation and Factor Va Function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

2 June 2018

Thrombin-catalyzed activation of recombinant human factor V.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

2 June 2018

Functional mapping of the surface residues of human thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

2 June 2018

The factor V B-domain provides two functions to facilitate thrombin cleavage and release of the light chain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

2 June 2018

A control switch for prothrombinase: characterization of a hirudin-like pentapeptide from the COOH terminus of factor Va heavy chain that regulates the rate and pathway for prothrombin activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

27 November 2018

The structural integrity of anion binding exosite I of thrombin is required and sufficient for timely cleavage and activation of factor V and factor VIII.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

27 November 2018

Role of prothrombin fragment 1 in the pathway of regulatory exosite I formation during conversion of human prothrombin to thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

27 November 2018

Structural requirements for expression of factor Va activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

27 November 2018

Defining the factor Xa-binding site on factor Va by site-directed glycosylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

27 November 2018

An extensive interaction interface between thrombin and factor V is required for factor V activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

27 November 2018

Posttranslational sulfation of factor V is required for efficient thrombin cleavage and activation and for full procoagulant activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143557

27 November 2018

Role of interactions involving C-terminal nonpolar residues of hirudin in the formation of the thrombin-hirudin complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/21555742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An Ambiguous Structure of a DNA 15-mer Thrombin Complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/21555742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of proexosite I in factor Va-dependent substrate interactions of prothrombin activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21555742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonpolar interactions of thrombin and its inhibitors at the fibrinogen recognition exosite: thermodynamic analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21555742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin-catalyzed activation of human coagulation factor V

1 reference

https://pubmed.ncbi.nlm.nih.gov/21555742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of proexosite I on prothrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21555742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Active-site-selective labeling of blood coagulation proteinases with fluorescence probes by the use of thioester peptide chloromethyl ketones. I. Specificity of thrombin labeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/21555742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Active-site-selective labeling of blood coagulation proteinases with fluorescence probes by the use of thioester peptide chloromethyl ketones. II. Properties of thrombin derivatives as reporters of prothrombin fragment 2 binding and specificity of t

1 reference

https://pubmed.ncbi.nlm.nih.gov/21555742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Demonstration of exosite I-dependent interactions of thrombin with human factor V and factor Va involving the factor Va heavy chain: analysis by affinity chromatography employing a novel method for active-site-selective immobilization of serine prot

1 reference

https://pubmed.ncbi.nlm.nih.gov/21555742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of regulatory exosite I in binding of thrombin to human factor V, factor Va, factor Va subunits, and activation fragments

1 reference

https://pubmed.ncbi.nlm.nih.gov/21555742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of thrombin anion-binding exosites 1 and 2 in the activation of factor V and factor VIII

1 reference

https://pubmed.ncbi.nlm.nih.gov/21555742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of thrombin by antithrombin is accompanied by inactivation of regulatory exosite I

1 reference

https://pubmed.ncbi.nlm.nih.gov/21555742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Hirudin-like factor Va heavy chain sequences in prothrombinase function

1 reference

https://pubmed.ncbi.nlm.nih.gov/21555742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cleavage requirements for activation of factor V by factor Xa

1 reference

https://pubmed.ncbi.nlm.nih.gov/21555742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1182/BLOOD-2010-10-315309

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21555742%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

PMC publication ID

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Europe PubMed Central

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31 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21555742%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

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