(Q27670915)

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Structural and Biochemical Studies of the Hedamycin Type II Polyketide Ketoreductase ( Hed KR): Molecular Basis of Stereo- and Regiospecificities

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scholarly article

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Structural and Biochemical Studies of the Hedamycin Type II Polyketide Ketoreductase ( Hed KR): Molecular Basis of Stereo- and Regiospecificities (English)

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3

object named as

Chaitan Khosla

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author name string

Pouya Javidpour

1

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Abhirup Das

2

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Shiou-Chuan Tsai

4

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language of work or name

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publication date

30 August 2011

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50

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34

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7426-39

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Structural and Biochemical Analyses of Regio- and Stereospecificities Observed in a Type II Polyketide Ketoreductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175028

20 March 2017

Inhibition Kinetics and Emodin Cocrystal Structure of a Type II Polyketide Ketoreductase † , ‡

1 reference

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20 March 2017

Crystal structures of two tropinone reductases: different reaction stereospecificities in the same protein fold

1 reference

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20 March 2017

Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase

1 reference

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20 March 2017

REFMAC5 dictionary: organization of prior chemical knowledge and guidelines for its use

1 reference

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20 March 2017

Coot: model-building tools for molecular graphics

1 reference

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20 March 2017

The CCP4 suite: programs for protein crystallography

1 reference

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20 March 2017

AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR

1 reference

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20 March 2017

Polyketide chain length control by chain length factor

1 reference

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20 March 2017

MCAT is not required for in vitro polyketide synthesis in a minimal actinorhodin polyketide synthase from Streptomyces coelicolor

1 reference

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20 March 2017

Improved protein-ligand docking using GOLD

1 reference

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7 April 2017

Biosynthesis of aromatic polyketides in bacteria

1 reference

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29 September 2017

Protein structure homology modeling using SWISS-MODEL workspace.

1 reference

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29 September 2017

Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms

1 reference

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29 September 2017

Short-chain dehydrogenases/reductases (SDR): the 2002 update

1 reference

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29 September 2017

Critical residues for structure and catalysis in short-chain dehydrogenases/reductases

1 reference

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29 September 2017

Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs.

1 reference

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29 September 2017

Genetic Contributions to Understanding Polyketide Synthases

1 reference

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29 September 2017

Polyketide biosynthesis: a millennium review

1 reference

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29 September 2017

Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli

1 reference

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29 September 2017

Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase

1 reference

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29 September 2017

Protein folding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175028

29 September 2017

Cloning and heterologous expression of a gene cluster for the biosynthesis of tetracenomycin C, the anthracycline antitumor antibiotic of Streptomyces glaucescens

1 reference

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29 September 2017

Cloning and expression of daunorubicin biosynthesis genes from Streptomyces peucetius and S. peucetius subsp. caesius

1 reference

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29 September 2017

The crystal structure of the actIII actinorhodin polyketide reductase: proposed mechanism for ACP and polyketide binding

1 reference

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2 June 2018

Engineered biosynthesis of novel polyketides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175028

2 June 2018

Insights into the stereospecificity of ketoreduction in a modular polyketide synthase

1 reference

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27 November 2018

In vivo and in vitro analysis of the hedamycin polyketide synthase

1 reference

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27 November 2018

Heterologous biosynthesis of amidated polyketides with novel cyclization regioselectivity from oxytetracycline polyketide synthase.

1 reference

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27 November 2018

High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175028

27 November 2018

Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase

1 reference

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27 November 2018

Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity

1 reference

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27 November 2018

Heterologous biosynthesis of truncated hexaketides derived from the actinorhodin polyketide synthase.

1 reference

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27 November 2018

The hedamycin locus implicates a novel aromatic PKS priming mechanism

1 reference

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27 November 2018

Enhancing the modularity of the modular polyketide synthases: transacylation in modular polyketide synthases catalyzed by malonyl-CoA:ACP transacylase

1 reference

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27 November 2018

Stereochemistry of catalysis by the ketoreductase activity in the first extension module of the erythromycin polyketide synthase

1 reference

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27 November 2018

Molecular Basis of Celmer's Rules: Stereochemistry of Catalysis by Isolated Ketoreductase Domains from Modular Polyketide Synthases

1 reference

https://pubmed.ncbi.nlm.nih.gov/21776967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://pubmed.ncbi.nlm.nih.gov/21776967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hedamycin, a new antitumor antibiotic. I. Production, isolation, and characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/21776967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hedamycin, a new antitumor antibiotic. II. Biological properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/21776967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host

1 reference

https://pubmed.ncbi.nlm.nih.gov/21776967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hedamycin intercalates the DNA helix and, through carbohydrate-mediated recognition in the minor groove, directs N7-alkylation of guanine in the major groove in a sequence-specific manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/21776967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI2006866

1 reference

Consolidated OpenCitations Corpus – April 2017

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OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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