(Q27675383)

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Crystal Structure of Thrombin in Complex with S-Variegin: Insights of a Novel Mechanism of Inhibition and Design of Tunable Thrombin Inhibitors

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22053189%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Crystal structure of thrombin in complex with S-variegin: insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors (English)

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22053189%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

crystal structure

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1

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15 January 2020

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15 January 2020

Manjunatha Kini

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15 January 2020

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Sundramurthy Kumar

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15 January 2020

Maria Kazimirova

3

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15 January 2020

Uvaraj P Radhakrishnan

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15 January 2020

Seongcheol Kim

6

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15 January 2020

Pudur Jagadeeswaran

7

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15 January 2020

Takayuki Imamura

8

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15 January 2020

Jun Mizuguchi

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15 January 2020

Sadaaki Iwanaga

10

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15 January 2020

Kunchithapadam Swaminathan

11

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15 January 2020

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28 October 2011

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15 January 2020

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15 January 2020

6

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15 January 2020

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15 January 2020

e26367

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15 January 2020

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Creative Commons Attribution 4.0 International

28 October 2011

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April 2022 Public Data File from Crossref

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Crystal Structure of Thrombin Bound to the Uncleaved Extracellular Fragment of PAR1

1 reference

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Isolation, Cloning and Structural Characterisation of Boophilin, a Multifunctional Kunitz-Type Proteinase Inhibitor from the Cattle Tick

1 reference

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20 March 2017

Structural identification of the pathway of long-range communication in an allosteric enzyme

1 reference

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20 March 2017

Crystal Structure of a Biosynthetic Sulfo-hirudin Complexed to Thrombin

1 reference

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20 March 2017

Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4

1 reference

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20 March 2017

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

1 reference

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20 March 2017

Design of P1' and P3' residues of trivalent thrombin inhibitors and their crystal structures

1 reference

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20 March 2017

The ornithodorin-thrombin crystal structure, a key to the TAP enigma?

1 reference

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20 March 2017

Bovine thrombin complexed with an uncleavable analog of residues 7-19 of fibrinogen A alpha: geometry of the catalytic triad and interactions of the P1', P2', and P3' substrate residues

1 reference

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20 March 2017

Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin

1 reference

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20 March 2017

The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203879

20 March 2017

The structure of a complex of recombinant hirudin and human alpha-thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203879

20 March 2017

Structure of the hirugen and hirulog 1 complexes of alpha-thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203879

20 March 2017

Refined structure of the hirudin-thrombin complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203879

20 March 2017

Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203879

20 March 2017

The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203879

20 March 2017

Phasercrystallographic software

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203879

20 March 2017

Inference of macromolecular assemblies from crystalline state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203879

20 March 2017

Coot: model-building tools for molecular graphics

1 reference

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20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203879

20 March 2017

Use of TLS parameters to model anisotropic displacements in macromolecular refinement

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203879

20 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203879

29 September 2017

New anticoagulants for treatment of venous thromboembolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203879

20 March 2017

Thrombin-specific inhibition by and slow cleavage of hirulog-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203879

20 March 2017

Structural basis of substrate specificity in the serine proteases

1 reference

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7 April 2017

Protein inhibitors of proteinases

1 reference

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7 April 2017

How Na+ activates thrombin--a review of the functional and structural data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203879

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203879

29 September 2017

The direct thrombin inhibitor hirudin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203879

29 September 2017

Variegin, a novel fast and tight binding thrombin inhibitor from the tropical bont tick.

1 reference

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29 September 2017

Laser-induced thrombosis in zebrafish larvae: a novel genetic screening method for thrombosis

1 reference

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29 September 2017

Argatroban: update

1 reference

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Coagulation and atherothrombotic disease

1 reference

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Determinants of specificity in coagulation proteases

1 reference

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29 September 2017

Molecular recognition mechanisms of thrombin

1 reference

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29 September 2017

Directing thrombin

1 reference

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29 September 2017

Thrombin-directed inhibitors: pharmacology and clinical use.

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29 September 2017

Antihemostatic strategies of blood-feeding arthropods

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29 September 2017

Preparation of recombinant alpha-thrombin: high-level expression of recombinant human prethrombin-2 and its activation by recombinant ecarin

1 reference

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29 September 2017

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29 September 2017

Site-specific dissection of substrate recognition by thrombin

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29 September 2017

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1 reference

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29 September 2017

Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human alpha-thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203879

29 September 2017

Thrombin inhibitors as antithrombotic agents: the importance of rapid inhibition

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29 September 2017

The interaction of thrombin with fibrinogen. A structural basis for its specificity

1 reference

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29 September 2017

The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution

1 reference

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29 September 2017

Processing of X-ray diffraction data collected in oscillation mode

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2 June 2018

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1 reference

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2 June 2018

Interaction of site specific hirudin variants with alpha-thrombin.

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2 June 2018

Use of site-directed mutagenesis to investigate the basis for the specificity of hirudin.

1 reference

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Noncompetitive inhibitor of thrombin.

1 reference

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27 November 2018

Design and characterization of hirulogs: a novel class of bivalent peptide inhibitors of thrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22053189

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dabigatran etexilate

1 reference

https://pubmed.ncbi.nlm.nih.gov/22053189

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonpolar interactions of thrombin S' subsites with its bivalent inhibitor: methyl scan of the inhibitor linker

1 reference

https://pubmed.ncbi.nlm.nih.gov/22053189

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anticoagulants from hematophagous animals

1 reference

https://pubmed.ncbi.nlm.nih.gov/22053189

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate

1 reference

https://pubmed.ncbi.nlm.nih.gov/22053189

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0026367

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22053189%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

2011PLoSO...626367K

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Europe PubMed Central

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15 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22053189%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

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