(Q27675436)

14

0 references

Micah Steffek

15

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author name string

Christopher E Heise

1

0 references

Jeremy Murray

2

0 references

Katherine E Augustyn

3

0 references

Brandon Bravo

4

0 references

Preeti Chugha

5

0 references

Frederick Cohen

6

0 references

Anthony M Giannetti

7

0 references

Paul Gibbons

8

0 references

Rami N Hannoush

9

0 references

Brian R Hearn

10

0 references

Priyadarshini Jaishankar

11

0 references

Cuong Q Ly

12

0 references

Kinjalkumar Shah

13

0 references

Yinyan Tang

16

0 references

Xianrui Zhao

17

0 references

Joseph W Lewcock

18

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Adam R Renslo

19

0 references

John Flygare

20

0 references

Michelle R Arkin

Creative Commons Attribution 4.0 International

21

0 references

language of work or name

English

0 references

publication date

2012

0 references

published in

PLOS One

0 references

volume

7

0 references

issue

12

0 references

page(s)

e50864

0 references

copyright license

start time

5 December 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Structural and Enzymatic Insights into Caspase-2 Protein Substrate Recognition and Catalysis

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Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation

20 March 2017

1 reference

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SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator

20 March 2017

1 reference

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

20 March 2017

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SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

20 March 2017

1 reference

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APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

20 March 2017

1 reference

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Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini

20 March 2017

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Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex

20 March 2017

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Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis

20 March 2017

1 reference

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Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid

20 March 2017

1 reference

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Coot: model-building tools for molecular graphics

20 March 2017

1 reference

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Mechanisms of caspase activation

20 March 2017

1 reference

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Mammalian caspases: structure, activation, substrates, and functions during apoptosis

20 March 2017

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20 March 2017

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Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

7 April 2017

1 reference

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Resveratrol is not a direct activator of SIRT1 enzyme activity

20 March 2017

1 reference

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Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

20 March 2017

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A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C

20 March 2017

1 reference

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Caspase-6 and neurodegeneration.

20 March 2017

1 reference

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From experimental design to validated hits a comprehensive walk-through of fragment lead identification using surface plasmon resonance

29 September 2017

1 reference

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Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models

29 September 2017

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Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo.

29 September 2017

1 reference

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Emerging principles in protease-based drug discovery

29 September 2017

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In search of negative allosteric modulators of biological targets

29 September 2017

1 reference

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Caspases in apoptosis and beyond

29 September 2017

1 reference

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Activation of caspase-6 in aging and mild cognitive impairment

29 September 2017

1 reference

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A common allosteric site and mechanism in caspases

29 September 2017

1 reference

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The protein structures that shape caspase activity, specificity, activation and inhibition

29 September 2017

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Discovery of an allosteric site in the caspases

29 September 2017

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Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease

29 September 2017

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Caspase activation: the induced-proximity model

29 September 2017

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Mycophenolic acid and thiazole adenine dinucleotide inhibition of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase: implications on enzyme mechanism

29 September 2017

1 reference

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Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells.

2 June 2018

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Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity

21 January 2018

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Ligand efficiency indices as guideposts for drug discovery.

21 January 2018

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Chemical mechanism of a cysteine protease, cathepsin C, as revealed by integration of both steady-state and pre-steady-state solvent kinetic isotope effects

21 January 2018

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Selective identification of cooperatively binding fragments in a high-throughput ligation assay enables development of a picomolar caspase-3 inhibitor.

21 January 2018

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Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.

21 January 2018

1 reference

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Enzyme kinetics and binding studies on inhibitors of MEK protein kinase

21 January 2018

1 reference

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Strong and weak hydrogen bonds in the protein-ligand interface

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23227217