(Q27675903)

1

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Bogdan I Florea

object named as

Bogdan I Florea

9

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Herman S Overkleeft

object named as

Herman S Overkleeft

14

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author name string

Wouter A van der Linden

2

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Anne C Mirabella

3

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Nerea Gallastegui

4

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Gerjan de Bruin

5

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Annet E M Blom

6

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Mathias J Voges

7

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Elliot D Mock

8

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Gijs A van der Marel

10

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Christoph Driessen

11

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Mario van der Stelt

12

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Alexei F Kisselev

Journal of Medicinal Chemistry

15

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language of work or name

English

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publication date

14 February 2013

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published in

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volume

56

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issue

3

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page(s)

1262-75

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cites work

Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity

1 reference

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The structure of the mammalian 20S proteasome at 2.75 A resolution

20 March 2017

1 reference

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Structure of 20S proteasome from yeast at 2.4 A resolution

20 March 2017

1 reference

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Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution

20 March 2017

1 reference

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Features and development of Coot

20 March 2017

1 reference

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Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

20 March 2017

1 reference

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REFMAC5 dictionary: organization of prior chemical knowledge and guidelines for its use

20 March 2017

1 reference

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SFCHECK: a unified set of procedures for evaluating the quality of macromolecular structure-factor data and their agreement with the atomic model

20 March 2017

1 reference

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

1 reference

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An extensively modified version of MolScript that includes greatly enhanced coloring capabilities

20 March 2017

1 reference

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The PubChem chemical structure sketcher

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782865

The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782865

Unraveling hot spots in binding interfaces: progress and challenges

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782865

Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib

7 April 2017

1 reference

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Nature of pharmacophore influences active site specificity of proteasome inhibitors

29 September 2017

1 reference

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Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t

29 September 2017

1 reference

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Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782865

A phase 1 dose escalation study of the safety and pharmacokinetics of the novel proteasome inhibitor carfilzomib (PR-171) in patients with hematologic malignancies

29 September 2017

1 reference

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Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782865

SYBYL line notation (SLN): a single notation to represent chemical structures, queries, reactions, and virtual libraries

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782865

CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782865

A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782865

Cysteine cathepsins: multifunctional enzymes in cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782865

A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782865

Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782865

Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782865

The development of proteasome inhibitors as anticancer drugs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782865

The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782865

Global analysis of proteasomal substrate specificity using positional-scanning libraries of covalent inhibitors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782865

Cathepsin S and related lysosomal endopeptidases.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782865

A panel of subunit-selective activity-based proteasome probes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782865

Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782865

Incorporation of fluorinated phenylalanine generates highly specific inhibitor of proteasome's chymotrypsin-like sites

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782865

Gonadotropin-Releasing Hormone Antagonists: Novel Members of the Azaline B Family

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782865

Acetylene functionalized BODIPY dyes and their application in the synthesis of activity based proteasome probes

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782865

Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782865

The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782865

Probing structural determinants distal to the site of hydrolysis that control substrate specificity of the 20S proteasome.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782865

Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23320547