(Q27676219)

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3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against Picornaviruses

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3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against Picornaviruses (English)

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8

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Rolf Hilgenfeld

12

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Markus Perbandt

4

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10

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11

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Céline Lacroix

object named as

Céline Lacroix

9

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object named as

Helene Norder

7

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2

object named as

Shyla George

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3

object named as

Yuri Kusov

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author name string

Jinzhi Tan

1

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Stefan Anemüller

5

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Jeroen R Mesters

6

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publication date

April 2013

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Journal of Virology

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87

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8

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4339-51

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Structural Basis for Antiviral Inhibition of the Main Protease, 3C, from Human Enterovirus 93

1 reference

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20 March 2017

Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design

1 reference

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20 March 2017

Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds

1 reference

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20 March 2017

A structural view of the inactivation of the SARS coronavirus main proteinase by benzotriazole esters

1 reference

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20 March 2017

Design of wide-spectrum inhibitors targeting coronavirus main proteases

1 reference

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20 March 2017

Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs

1 reference

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20 March 2017

Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes

1 reference

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20 March 2017

Refined X-ray crystallographic structure of the poliovirus 3C gene product

1 reference

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20 March 2017

The refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognition

1 reference

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20 March 2017

Scaling and assessment of data quality

1 reference

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Coot: model-building tools for molecular graphics

1 reference

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20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

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20 March 2017

The CCP4 suite: programs for protein crystallography

1 reference

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20 March 2017

SFCHECK: a unified set of procedures for evaluating the quality of macromolecular structure-factor data and their agreement with the atomic model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3624371

20 March 2017

Solvent content of protein crystals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3624371

20 March 2017

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3624371

20 March 2017

Statistical estimations in enzyme kinetics

1 reference

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7 April 2017

Structure-based antivirals for emerging and neglected RNA viruses: an emerging field for medicinal chemistry in academia

1 reference

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29 September 2017

Picornavirus non-structural proteins as targets for new anti-virals with broad activity

1 reference

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29 September 2017

Recent advances in targeting viral proteases for the discovery of novel antivirals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3624371

29 September 2017

Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3624371

29 September 2017

A case for developing antiviral drugs against polio

1 reference

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29 September 2017

Novel CADD-based peptidyl vinyl ester derivatives as potential proteasome inhibitors.

1 reference

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29 September 2017

A versatile ligation-independent cloning method suitable for high-throughput expression screening applications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3624371

29 September 2017

Enterovirus 68 is associated with respiratory illness and shares biological features with both the enteroviruses and the rhinoviruses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3624371

29 September 2017

Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3624371

29 September 2017

Human rhinovirus 87 and enterovirus 68 represent a unique serotype with rhinovirus and enterovirus features

1 reference

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29 September 2017

Human rhinovirus 87 identified as human enterovirus 68 by VP4-based molecular diagnosis

1 reference

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29 September 2017

Replication of a hepatitis A virus replicon detected by genetic recombination in vivo

1 reference

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29 September 2017

Mutations within the 5' nontranslated RNA of cell culture-adapted hepatitis A virus which enhance cap-independent translation in cultured African green monkey kidney cells

1 reference

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Poliovirus RNA synthesis utilizes an RNP complex formed around the 5'-end of viral RNA.

1 reference

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29 September 2017

Enterovirus 71 outbreak in the People's Republic of China in 2008.

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27 November 2018

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27 November 2018

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1 reference

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27 November 2018

More hydrogen bonds for the (structural) biologist.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3624371

27 November 2018

Development of potent inhibitors of the coxsackievirus 3C protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23388726

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The molecular replacement method

1 reference

https://pubmed.ncbi.nlm.nih.gov/23388726

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-H...pi-interactions in proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/23388726

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/JVI.01123-12

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