(Q27676674)

1

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Chad D Walls

3

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Lan Chen

4

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Sheng Zhang

5

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Ruoyu Zhang

6

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Li Wu

7

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Lina Wang

8

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Sijiu Liu

9

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Zhong-Yin Zhang

Journal of Biological Chemistry

10

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language of work or name

English

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publication date

12 April 2013

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published in

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volume

288

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issue

15

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page(s)

10472-82

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cites work

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Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2

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Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome

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PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects

20 March 2017

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Germline mutations in HRAS proto-oncogene cause Costello syndrome

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Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

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29 September 2017

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Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

2 June 2018

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Transgenic Drosophila models of Noonan syndrome causing PTPN11 gain-of-function mutations

21 January 2018

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Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

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MOLREP: an Automated Program for Molecular Replacement

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.450023

A common requirement for the catalytic activity and both SH2 domains of SHP-2 in mitogen-activated protein (MAP) kinase activation by the ErbB family of receptors. A specific role for SHP-2 in map, but not c-Jun amino-terminal kinase activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.450023

Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.450023

Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.450023

Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.450023

PTPN11 mutations in LEOPARD syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.450023

Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23457302

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Requirement of SHP2 binding to Grb2-associated binder-1 for mitogen-activated protein kinase activation in response to lysophosphatidic acid and epidermal growth factor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23457302

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Potent stimulation of SH-PTP2 phosphatase activity by simultaneous occupancy of both SH2 domains

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23457302