(Q27677405)

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Extreme Multidrug Resistant HIV-1 Protease with 20 Mutations Is Resistant to Novel Protease Inhibitors with P1′-Pyrrolidinone or P2-Tris-tetrahydrofuran

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scholarly article

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Extreme Multidrug Resistant HIV-1 Protease with 20 Mutations Is Resistant to Novel Protease Inhibitors with P1′-Pyrrolidinone or P2-Tris-tetrahydrofuran (English)

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multiple drug resistance

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Johnson Agniswamy

1

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9

object named as

Irene T Weber

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author name string

Chen-Hsiang Shen

2

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Yuan-Fang Wang

3

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Arun K Ghosh

4

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Kalapala Venkateswara Rao

5

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Chun-Xiao Xu

6

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Jane M Sayer

7

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John M Louis

8

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language of work or name

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publication date

23 May 2013

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Journal of Medicinal Chemistry

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56

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10

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4017-27

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Novel P2 Tris-tetrahydrofuran Group in Antiviral Compound 1 (GRL-0519) Fills the S2 Binding Pocket of Selected Mutants of HIV-1 Protease

1 reference

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20 March 2017

Extreme Entropy–Enthalpy Compensation in a Drug-Resistant Variant of HIV-1 Protease

1 reference

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20 March 2017

HIV-1 Protease with 20 Mutations Exhibits Extreme Resistance to Clinical Inhibitors through Coordinated Structural Rearrangements

1 reference

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20 March 2017

Potent Antiviral HIV-1 Protease Inhibitor GRL-02031 Adapts to the Structures of Drug Resistant Mutants with Its P1′-Pyrrolidinone Ring

1 reference

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20 March 2017

Critical differences in HIV-1 and HIV-2 protease specificity for clinical inhibitors

1 reference

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20 March 2017

Probing Multidrug-Resistance and Protein-Ligand Interactions with Oxatricyclic Designed Ligands in HIV-1 Protease Inhibitors

1 reference

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20 March 2017

Autocatalytic maturation, physical/chemical properties, and crystal structure of group N HIV-1 protease: Relevance to drug resistance

1 reference

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20 March 2017

Amprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clusters

1 reference

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20 March 2017

HIV-1 protease inhibitors with a transition-state mimic comprising a tertiary alcohol: improved antiviral activity in cells

1 reference

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20 March 2017

Resistance mechanism revealed by crystal structures of unliganded nelfinavir-resistant HIV-1 protease non-active site mutants N88D and N88S

1 reference

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20 March 2017

Design of HIV-1 Protease Inhibitors with Pyrrolidinones and Oxazolidinones as Novel P1′-Ligands To Enhance Backbone-Binding Interactions with Protease: Synthesis, Biological Evaluation, and Protein−Ligand X-ray Studies ∞

1 reference

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20 March 2017

Molecular analysis of the HIV-1 resistance development: enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants

1 reference

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AIDS — The First 20 Years

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20 March 2017

Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes

1 reference

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20 March 2017

SHELXL: high-resolution refinement

1 reference

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20 March 2017

Likelihood-enhanced fast translation functions

1 reference

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20 March 2017

Coot: model-building tools for molecular graphics

1 reference

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20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719844

20 March 2017

Likelihood-enhanced fast rotation functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719844

20 March 2017

In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719844

7 April 2017

Surveillance of transmitted HIV drug resistance using matched plasma and dried blood spot specimens from voluntary counseling and testing sites in Ho Chi Minh City, Vietnam, 2007-2008.

1 reference

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29 September 2017

Surveillance of transmitted HIV-1 drug resistance in Gauteng and KwaZulu-Natal Provinces, South Africa, 2005-2009.

1 reference

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29 September 2017

Update on World Health Organization HIV drug resistance prevention and assessment strategy: 2004-2011

1 reference

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29 September 2017

Activity of human immunodeficiency virus type 1 protease inhibitors against the initial autocleavage in Gag-Pol polyprotein processing

1 reference

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29 September 2017

HIV prevention by oral preexposure prophylaxis

1 reference

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29 September 2017

Enhancing protein backbone binding--a fruitful concept for combating drug-resistant HIV.

1 reference

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29 September 2017

Flexible catalytic site conformations implicated in modulation of HIV-1 protease autoprocessing reactions

1 reference

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29 September 2017

HIV-1 drug resistance in antiretroviral-naive individuals in sub-Saharan Africa after rollout of antiretroviral therapy: a multicentre observational study

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29 September 2017

Inhibition of autoprocessing of natural variants and multidrug resistant mutant precursors of HIV-1 protease by clinical inhibitors

1 reference

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Molecular basis of human immunodeficiency virus drug resistance: an update.

1 reference

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29 September 2017

GRL-02031, a novel nonpeptidic protease inhibitor (PI) containing a stereochemically defined fused cyclopentanyltetrahydrofuran potent against multi-PI-resistant human immunodeficiency virus type 1 in vitro

1 reference

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29 September 2017

Solution kinetics measurements suggest HIV-1 protease has two binding sites for darunavir and amprenavir

1 reference

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Antiretroviral drug resistance testing in adult HIV-1 infection: 2008 recommendations of an International AIDS Society-USA panel

1 reference

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HIV drug development: the next 25 years

1 reference

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29 September 2017

Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114

1 reference

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29 September 2017

Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M.

1 reference

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Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor

1 reference

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27 November 2018

Patterns of primary antiretroviral drug resistance in antiretroviral-naive HIV-1-infected individuals in a midwest university clinic.

1 reference

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Oral absorption of the HIV protease inhibitors: a current update

1 reference

https://pubmed.ncbi.nlm.nih.gov/23590295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strong and weak hydrogen bonds in the protein-ligand interface

1 reference

https://pubmed.ncbi.nlm.nih.gov/23590295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Surveys of transmitted HIV drug resistance in 7 geographic Regions in China, 2008-2009

1 reference

https://pubmed.ncbi.nlm.nih.gov/23590295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://pubmed.ncbi.nlm.nih.gov/23590295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM400231V

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