(Q27678799)

10.1038/NCHEMBIO0812-737B

DOI

12 July 2019

http://api.crossref.org/works?select=update-to&filter=doi:10.1038/NCHEMBIO0812-737B

author

Gerard Drewes

22

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Gitte Neubauer

25

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Toby Mathieson

Toby Mathieson

14

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Giovanna Bergamini

Giovanna Bergamini

1

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Carsten Hopf

Carsten Hopf

10

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Emilio Hirsch

Emilio Hirsch

21

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Thilo Werner

4

Thilo Werner

0 references

Marcus Bantscheff

24

Marcus Bantscheff

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Jessica Perrin

7

Jessica Perrin

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Nigel G Ramsden

20

Nigel Ramsden

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Mikhail M Savitski

19

Mikhail M Savitski

0 references

Raffaella Mangano

13

Raffaella Mangano

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Carola Doce

11

Carola Doce

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author name string

Kathryn Bell

2

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Satoko Shimamura

3

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Andrew Cansfield

5

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Katrin Müller

6

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Christina Rau

8

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Katie Ellard

9

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Daniel Leggate

12

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Alison O'Mahony

15

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Ivan Plavec

16

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Faiza Rharbaoui

17

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Friedrich Reinhard

18

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Oliver Rausch

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

23

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publication date

29 April 2012

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published in

Nature Chemical Biology

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volume

8

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issue

6

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page(s)

576-82

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cites work

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Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

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A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

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A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding

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PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?

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PI3Kgamma inhibition: towards an 'aspirin of the 21st century'?

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Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90

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Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

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The emerging mechanisms of isoform-specific PI3K signalling

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

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IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

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Signalling through Class I PI3Ks in mammalian cells

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PI3Kgamma adaptor subunits define coupling to degranulation and cell motility by distinct PtdIns(3,4,5)P3 pools in mast cells.

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PI3K inhibition in inflammation: Toward tailored therapies for specific diseases.

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Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation.

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Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development

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Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells

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Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations

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A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.

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Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

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Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells.

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Proteomics strategy for quantitative protein interaction profiling in cell extracts.

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Chemical target and pathway toxicity mechanisms defined in primary human cell systems

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Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

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Requirement for PI 3-kinase gamma in macrophage migration to MCP-1 and CSF-1.

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Targeted data acquisition for improved reproducibility and robustness of proteomic mass spectrometry assays

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Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs

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Proinflammatory T helper type 17 cells are effective B-cell helpers

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PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

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PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis.

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Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.

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PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance

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Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance

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Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes

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Discovery of novel targets of quinoline drugs in the human purine binding proteome

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Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

21 January 2018

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Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells

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Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma

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PI3Kδ drives the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting effector T cell apoptosis and promoting Th17 differentiation.

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Phosphoinositide 3-kinases gamma and delta, linkers of coordinate C5a receptor-Fcgamma receptor activation and immune complex-induced inflammation

21 January 2018

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Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion

21 January 2018

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LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study

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Evaluation of data analysis strategies for improved mass spectrometry-based phosphoproteomics

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Delayed fragmentation and optimized isolation width settings for improvement of protein identification and accuracy of isobaric mass tag quantification on Orbitrap-type mass spectrometers

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12 December 2020

Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based models

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A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

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Infliximab treatment reduces the serum levels of interleukin-23 in patients with rheumatoid arthritis

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An integrative biology approach for analysis of drug action in models of human vascular inflammation

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12 December 2020