(Q39827973)

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Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20944678%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells (English)

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15 February 2020

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chronic lymphocytic leukemia

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Christian P. Pallasch

2

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15 February 2020

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15 February 2020

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U Kruse

1

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15 February 2020

M Bantscheff

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15 February 2020

D Eberhard

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15 February 2020

L Frenzel

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15 February 2020

S Ghidelli

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15 February 2020

S K Maier

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15 February 2020

T Werner

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15 February 2020

C M Wendtner

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15 February 2020

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14 October 2010

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15 February 2020

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15 February 2020

25

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15 February 2020

1

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15 February 2020

89-100

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15 February 2020

https://scigraph.springernature.com/pub.10.1038/leu.2010.233

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The kinase inhibitor dasatinib induces apoptosis in chronic lymphocytic leukemia cells in vitro with preference for a subgroup of patients with unmutated IgVH genes

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Novel molecular diagnostic and therapeutic targets in chronic lymphocytic leukaemia

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Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

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Quantitative phosphoproteomics by mass spectrometry: past, present, and future

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Proteomics strategy for quantitative protein interaction profiling in cell extracts.

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Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

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Chemical proteomics identifies unanticipated targets of clinical kinase inhibitors

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Overexpression of TOSO in CLL is triggered by B-cell receptor signaling and associated with progressive disease.

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Robust and sensitive iTRAQ quantification on an LTQ Orbitrap mass spectrometer

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Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents

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A quantitative analysis of kinase inhibitor selectivity

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The biological and clinical relationship between CD5+23+ monoclonal B-cell lymphocytosis and chronic lymphocytic leukaemia

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A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development

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Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors

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Features of selective kinase inhibitors

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N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent

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Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death

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Establishment of a novel human B-CLL-like xenograft model in nude mouse

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Negative selection of chronic lymphocytic leukaemia cells using a bifunctional rosette-based antibody cocktail

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Advancing therapy for chronic lymphocytic leukemia--the role of rituximab

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Identification of a kinase profile that predicts chromosome damage induced by small molecule kinase inhibitors

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The multi-tasking P-TEFb complex

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The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling

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Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

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Large-scale mapping of human protein-protein interactions by mass spectrometry

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Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity

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Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis

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The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib

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R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation

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B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406.

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Advancing Therapy For Chronic Lymphocytic Leukemia-the Role Of Rituximab

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7 January 2021

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10.1038/LEU.2010.233

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Europe PubMed Central

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15 February 2020

release_42s25ds7g5gsfna2it7ph2oilq

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15 February 2020

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