(Q27683399)

English

Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis

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scholarly article

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Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis (English)

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organic chemistry

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1 reference

based on heuristic

inferred from title

13

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Olivier Sperandio

10

object named as

Olivier Sperandio

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Nathalie Hennuyer

object named as

Nathalie Hennuyer

4

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object named as

Wei-Jen Tang

15

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object named as

Benoit Deprez

16

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object named as

Luc Buee

12

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object named as

Julie Charton

1

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object named as

Malika Hamdane

7

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Rébecca F Déprez-Poulain

object named as

Rebecca Deprez-Poulain

17

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object named as

Marion Flipo

11

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author name string

Marion Gauriot

2

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Qing Guo

3

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Xavier Marechal

5

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Julie Dumont

6

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Virginie Pottiez

8

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Valerie Landry

9

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Florence Leroux

14

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language of work or name

1 reference

based on heuristic

inferred from title

publication date

22 May 2014

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European Journal of Medicinal Chemistry

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79

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184-93

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Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

20 March 2017

Anion Activation Site of Insulin-degrading Enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

20 March 2017

Identification of the allosteric regulatory site of insulysin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

20 March 2017

Ubiquitin is a novel substrate for human insulin-degrading enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

20 March 2017

Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

20 March 2017

Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-α, and Amylin by Human Insulin-Degrading Enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

20 March 2017

Molecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading Enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

20 March 2017

Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

20 March 2017

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

20 March 2017

Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

20 March 2017

Involvement of insulin-degrading enzyme in the clearance of beta-amyloid at the blood-CSF barrier: Consequences of lead exposure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

20 March 2017

A genome-wide association study identifies novel risk loci for type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

20 March 2017

The insulysin (insulin degrading enzyme) enigma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

20 March 2017

Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

20 March 2017

Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

20 March 2017

Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

20 March 2017

Cell-permeable, small-molecule activators of the insulin-degrading enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

29 September 2017

Peptidomics approach to elucidate the proteolytic regulation of bioactive peptides.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

29 September 2017

Insulin-degrading enzyme: structure-function relationship and its possible roles in health and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

29 September 2017

Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

29 September 2017

Amyloid beta-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

29 September 2017

Regulation of protein degradation by insulin-degrading enzyme: analysis by small interfering RNA-mediated gene silencing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

29 September 2017

Intracellular pH regulates amyloid precursor protein intracellular domain accumulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

29 September 2017

Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

29 September 2017

Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

29 September 2017

Design of ester prodrugs to enhance oral absorption of poorly permeable compounds: challenges to the discovery scientist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

29 September 2017

Genetic variation in a haplotype block spanningIDE influences Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

29 September 2017

Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

29 September 2017

Functional relevance of a novel SlyX motif in non-conventional secretion of insulin-degrading enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

2 June 2018

Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

27 November 2018

Hydroxamates: relationships between structure and plasma stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

27 November 2018

Hyperglycaemia and hyperinsulinaemia: is insulin-degrading enzyme the missing link?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

27 November 2018

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

27 November 2018

Insulin inhibition of the proteasome is dependent on degradation of insulin by insulin-degrading enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

27 November 2018

Amyloidogenic determinant as a substrate recognition motif of insulin-degrading enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128174

27 November 2018

Functional human insulin-degrading enzyme can be expressed in bacteria

1 reference

https://pubmed.ncbi.nlm.nih.gov/24735644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation of insulin-like growth factors I and II by a human insulin degrading enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/24735644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for genetic linkage of Alzheimer's disease to chromosome 10q

1 reference

https://pubmed.ncbi.nlm.nih.gov/24735644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.EJMECH.2014.04.009

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PubMed publication ID

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