(Q27684056)

12

0 references

Biswaranjan Mohanty

14

0 references

Christine Beeton

Christine Beeton

19

0 references

Michael W Pennington

Michael W Pennington

20

0 references

Sandeep Chhabra

Sandeep Chhabra

1

0 references

Raymond Norton

21

ShK toxin: history, structure and therapeutic applications for autoimmune diseases

Raymond S Norton

0 references

22

K George Chandy

0 references

Jesus G Valenzuela

13

Jesus G Valenzuela

0 references

author name string

Shih Chieh Chang

2

0 references

Hai M Nguyen

3

0 references

Redwan Huq

4

0 references

Mark R Tanner

5

0 references

Luz M Londono

6

0 references

Rosendo Estrada

7

0 references

Vikas Dhawan

8

0 references

Satendra Chauhan

9

0 references

Sanjeev K Upadhyay

10

0 references

Mariel Gindin

11

0 references

James D Swarbrick

15

0 references

Heike Wulff

16

0 references

Shawn P Iadonato

17

0 references

George A Gutman

18

0 references

language of work or name

English

0 references

publication date

September 2014

0 references

published in

FASEB Journal

0 references

volume

28

0 references

issue

9

0 references

page(s)

3952-64

0 references

cites work

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1 reference

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Potassium channel modulation by a toxin domain in matrix metalloprotease 23

20 March 2017

1 reference

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Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes

20 March 2017

1 reference

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Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes

20 March 2017

1 reference

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Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block

20 March 2017

1 reference

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Kv1.5 association modifies Kv1.3 traffic and membrane localization

20 March 2017

1 reference

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Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis

20 March 2017

1 reference

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Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases

20 March 2017

1 reference

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The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain

20 March 2017

1 reference

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Trichuris suis therapy in Crohn's disease

20 March 2017

1 reference

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The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS

20 March 2017

1 reference

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Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis

20 March 2017

1 reference

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20 March 2017

The Protein Data Bank

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ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide

20 March 2017

1 reference

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On the convergent evolution of animal toxins. Conservation of a diad of functional residues in potassium channel-blocking toxins with unrelated structures

20 March 2017

1 reference

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Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone

20 March 2017

1 reference

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Automated NMR structure calculation with CYANA

20 March 2017

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UCSF Chimera--a visualization system for exploratory research and analysis

20 March 2017

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The Xplor-NIH NMR molecular structure determination package

20 March 2017

1 reference

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AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

MOLMOL: a program for display and analysis of macromolecular structures

20 March 2017

1 reference

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Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences

20 March 2017

1 reference

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Structural conservation of the pores of calcium-activated and voltage-gated potassium channels determined by a sea anemone toxin

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Association between parasite infection and immune responses in multiple sclerosis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

K+ channel expression during B cell differentiation: implications for immunomodulation and autoimmunity

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

A potassium-channel toxin from the sea anemone Bunodosoma granulifera, an inhibitor for Kv1 channels. Revision of the amino acid sequence, disulfide-bridge assignment, chemical synthesis, and biological activity

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Blocking KV1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Trichuris suis ova in relapsing-remitting multiple sclerosis and clinically isolated syndrome (TRIOMS): study protocol for a randomized controlled trial

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Protein backbone and sidechain torsion angles predicted from NMR chemical shifts using artificial neural networks

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Hookworm excretory/secretory products induce interleukin-4 (IL-4)+ IL-10+ CD4+ T cell responses and suppress pathology in a mouse model of colitis

29 September 2017

1 reference

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Vaccine against autoimmune disease: can helminths or their products provide a therapy?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Macrophage migration inhibitory factor (MIF): genetic evidence for participation in early onset and early stage rheumatoid arthritis.

29 September 2017

1 reference

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Childhood helminth exposure is protective against inflammatory bowel disease: a case control study in South Africa

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

A role for IL-22 in the relationship between intestinal helminths, gut microbiota and mucosal immunity.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Autoimmunity: The worm returns

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Cestode regulation of inflammation and inflammatory diseases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Regulatory T cells in human lymphatic filariasis: stronger functional activity in microfilaremics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Kv1.3 deletion biases T cells toward an immunoregulatory phenotype and renders mice resistant to autoimmune encephalomyelitis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Worm burden-dependent disruption of the porcine colon microbiota by Trichuris suis infection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Characterising the mucosal and systemic immune responses to experimental human hookworm infection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Probiotic helminth administration in relapsing-remitting multiple sclerosis: a phase 1 study

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

IL-22+ CD4+ T cells are associated with therapeutic trichuris trichiura infection in an ulcerative colitis patient.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Helminth-derived immunomodulators: can understanding the worm produce the pill?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Extracts of the rat tapeworm, Hymenolepis diminuta, suppress macrophage activation in vitro and alleviate chemically induced colitis in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

The functional network of ion channels in T lymphocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Binding of excreted and/or secreted products of adult hookworms to human NK cells in Necator americanus-infected individuals from Brazil

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Dose-ranging study for trials of therapeutic infection with Necator americanus in humans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Selective blockade of voltage-gated potassium channels reduces inflammatory bone resorption in experimental periodontal disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

A Subfamily of Acidic α-K+ Toxins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Schistosomiasis decreases central nervous system inflammation and alters the progression of experimental autoimmune encephalomyelitis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

A filarial cysteine protease inhibitor down-regulates T cell proliferation and enhances interleukin-10 production

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Improving the quality of NMR and crystallographic protein structures by means of a conformational database potential derived from structure databases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

A hookworm glycoprotein that inhibits neutrophil function is a ligand of the integrin CD11b/CD18.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Investigating the impact of helminth products on immune responsiveness using a TCR transgenic adoptive transfer system.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Macrophage migration inhibitory factor potentiates autoimmune-mediated neuroinflammation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Randomised clinical trial: the safety and tolerability of Trichuris suis ova in patients with Crohn's disease

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Therapeutic potential of helminth soluble proteins in TNBS-induced colitis in mice

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Identification of a 55 kDa Haemonchus contortus excretory/secretory glycoprotein as a neutrophil inhibitory factor.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Characterization of the functional properties of the voltage-gated potassium channel Kv1.3 in human CD4+ T lymphocytes.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Aurelin, a novel antimicrobial peptide from jellyfish Aurelia aurita with structural features of defensins and channel-blocking toxins.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Autoimmune CD4+ T cell memory: lifelong persistence of encephalitogenic T cell clones in healthy immune repertoires.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

A worm's eye view of the immune system: consequences for evolution of human autoimmune disease.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Gene transfer into CD4+ T lymphocytes: green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Functional interaction between the integrin antagonist neutrophil inhibitory factor and the I domain of CD11b/CD18.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139903

Ionisation behaviour and solution properties of the potassium-channel blocker ShK toxin

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24891519

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Modulation of macrophage cytokine production by ES-62, a secreted product of the filarial nematode Acanthocheilonema viteae

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24891519

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Soil-transmitted helminthiases: number of children treated in 2012

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24891519

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1096/FJ.14-251967

1 reference

1372285

1372285

1 reference

1 reference

1 reference