(Q27684632)

English

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase

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scholarly article

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Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase (English)

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crystal structure

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Alzheimer's disease

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based on heuristic

inferred from title

5

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1

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author name string

Eugénie Carletti

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Cyril Ronco

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Marie Trovaslet

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Ludovic Jean

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Pierre-Yves Renard

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language of work or name

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publication date

1 August 2013

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Biochemical Journal

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453

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3

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393-9

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Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent

1 reference

https://api.crossref.org/works/10.1042/BJ20130013

21 April 2017

Structures of human acetylcholinesterase in complex with pharmacologically important ligands

1 reference

https://api.crossref.org/works/10.1042/BJ20130013

21 April 2017

Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site

1 reference

https://api.crossref.org/works/10.1042/BJ20130013

21 April 2017

Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation

1 reference

https://api.crossref.org/works/10.1042/BJ20130013

21 April 2017

Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation

1 reference

https://api.crossref.org/works/10.1042/BJ20130013

21 April 2017

1 reference

https://api.crossref.org/works/10.1042/BJ20130013

21 April 2017

The CCP4 suite: programs for protein crystallography

1 reference

https://api.crossref.org/works/10.1042/BJ20130013

21 April 2017

Features and development of Coot

1 reference

https://api.crossref.org/works/10.1042/BJ20130013

21 April 2017

Three-dimensional structures ofDrosophila melanogasteracetylcholinesterase and of its complexes with two potent inhibitors

1 reference

https://api.crossref.org/works/10.1042/BJ20130013

21 April 2017

Crystallization and X-ray structure of full-length recombinant human butyrylcholinesterase

1 reference

https://api.crossref.org/works/10.1042/BJ20130013

21 April 2017

The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix

1 reference

https://api.crossref.org/works/10.1042/BJ20130013

21 April 2017

3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates

1 reference

https://api.crossref.org/works/10.1042/BJ20130013

21 April 2017

Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography

1 reference

https://api.crossref.org/works/10.1042/BJ20130013

21 April 2017

Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase

1 reference

https://api.crossref.org/works/10.1042/BJ20130013

21 April 2017

Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products

1 reference

https://api.crossref.org/works/10.1042/BJ20130013

21 April 2017

Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure

1 reference

https://api.crossref.org/works/10.1042/BJ20130013

21 April 2017

Alzheimer 100--highlights in the history of Alzheimer research.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130013

21 January 2018

Targeting acetylcholinesterase to treat neurodegeneration

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130013

21 January 2018

Non-cholinergic pharmacotherapy approaches to the future treatment of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130013

21 January 2018

Treatment of Alzheimer's disease in the long-term-care setting

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130013

21 January 2018

Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130013

21 January 2018

Neurobiology of butyrylcholinesterase.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130013

21 January 2018

Effects of cholinesterase inhibition on brain white matter volume in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130013

21 January 2018

Empirical evidence of neuroprotection by dual cholinesterase inhibition in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130013

21 January 2018

Advances in the treatment of Alzheimer's disease: benefits of dual cholinesterase inhibition.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130013

21 January 2018

Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130013

21 January 2018

Tacrine derivatives and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130013

21 January 2018

Multi-target-directed ligands to combat neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130013

21 January 2018

Multifunctional neuroprotective drugs targeting monoamine oxidase inhibition, iron chelation, adenosine receptors, and cholinergic and glutamatergic action for neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130013

21 January 2018

Acetylcholinesterase: a multifaceted target for structure-based drug design of anticholinesterase agents for the treatment of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130013

21 January 2018

Engineering of a monomeric and low-glycosylated form of human butyrylcholinesterase: expression, purification, characterization and crystallization

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130013

21 January 2018

PHENIX: a comprehensive Python-based system for macromolecular structure solution

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130013

21 January 2018

A four-to-one association between peptide motifs: four C-terminal domains from cholinesterase assemble with one proline-rich attachment domain (PRAD) in the secretory pathway

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130013

21 January 2018

Soluble monomeric acetylcholinesterase from mouse: expression, purification, and crystallization in complex with fasciculin.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130013

21 January 2018

Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130013

21 January 2018

Insights into substrate and product traffic in the Drosophila melanogaster acetylcholinesterase active site gorge by enlarging a back channel.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130013

21 January 2018

Genome organization, phylogenies, expression patterns, and three-dimensional protein models of two acetylcholinesterase genes from the red flour beetle

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130013

21 January 2018

Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130013

21 January 2018

Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica 1 1Edited by R. Huber

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130013

21 January 2018

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