(Q27694779)

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Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen

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Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen (English)

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Rasheduzzaman Chowdhury

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25120187%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Christopher J. Schofield

7

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25120187%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Ivanhoe K. H. Leung

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25120187%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

James S. McCullagh

5

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25120187%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

8

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25120187%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Hanna Tarhonskaya

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Hanna Tarhonskaya

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Europe PubMed Central

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3 June 2020

Timothy D W Claridge

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Timothy D W Claridge

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3 June 2020

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Nikita D Loik

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Europe PubMed Central

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3 June 2020

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publication date

1 November 2014

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number of pages

10

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Biochemical Journal

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Europe PubMed Central

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3 June 2020

463

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Europe PubMed Central

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3 June 2020

3

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3 June 2020

363-372

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3 June 2020

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

1 reference

https://api.crossref.org/works/10.1042/BJ20140779

21 April 2017

Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2

1 reference

https://api.crossref.org/works/10.1042/BJ20140779

21 April 2017

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

1 reference

https://api.crossref.org/works/10.1042/BJ20140779

21 April 2017

FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes

1 reference

https://api.crossref.org/works/10.1042/BJ20140779

21 April 2017

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen

1 reference

https://api.crossref.org/works/10.1042/BJ20140779

21 April 2017

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases

1 reference

https://api.crossref.org/works/10.1042/BJ20140779

21 April 2017

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate

1 reference

https://api.crossref.org/works/10.1042/BJ20140779

21 April 2017

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

1 reference

https://api.crossref.org/works/10.1042/BJ20140779

21 April 2017

Evidence That Two Enzyme-derived Histidine Ligands Are Sufficient for Iron Binding and Catalysis by Factor Inhibiting HIF (FIH)

1 reference

https://api.crossref.org/works/10.1042/BJ20140779

21 April 2017

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

1 reference

https://api.crossref.org/works/10.1042/BJ20140779

21 April 2017

Structural basis for inhibition of the fat mass and obesity associated protein (FTO)

1 reference

https://api.crossref.org/works/10.1042/BJ20140779

21 April 2017

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

1 reference

https://api.crossref.org/works/10.1042/BJ20140779

21 April 2017

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

1 reference

https://api.crossref.org/works/10.1042/BJ20140779

21 April 2017

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 April 2017

Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

Oxygen sensing, homeostasis, and disease

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

The human oxygen sensing machinery and its manipulation

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

Hypoxia-inducible factor prolyl 4-hydroxylases: common and specific roles

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

The HIF pathway as a therapeutic target

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

Dioxygenases as O2-dependent regulators of the hypoxic response pathway

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

Reactivation of hepatic EPO synthesis in mice after PHD loss

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

The first direct characterization of a high-valent iron intermediate in the reaction of an alpha-ketoglutarate-dependent dioxygenase: a high-spin FeIV complex in taurine/alpha-ketoglutarate dioxygenase (TauD) from Escherichia coli

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

Direct spectroscopic detection of a C-H-cleaving high-spin Fe(IV) complex in a prolyl-4-hydroxylase

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

Substrate-triggered formation and remarkable stability of the C-H bond-cleaving chloroferryl intermediate in the aliphatic halogenase, SyrB2

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

Studies on deacetoxycephalosporin C synthase support a consensus mechanism for 2-oxoglutarate dependent oxygenases.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

The binding of monosaccharide inhibitors to hen egg-white lysozyme by proton magnetic resonance at 270 MHz and analysis by ring-current calculations

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

Kinetic characterization and identification of a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 using a time-resolved fluorescence resonance energy transfer-based assay technology

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

PHD2 mutation and congenital erythrocytosis with paraganglioma.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

Inverse solvent isotope effects demonstrate slow aquo release from hypoxia inducible factor-prolyl hydroxylase (PHD2)

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140779

21 January 2018

Identifiers

10.1042/BJ20140779

2 references

Consolidated OpenCitations Corpus – April 2017

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25120187%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25120187%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

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