(Q38128383)

29 August 2017

title

Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology (English)

1 reference

29 August 2017

0 references

1 reference

1 reference

1

Gregg L Semenza

1 reference

29 August 2017

publication date

7 August 2013

1 reference

Annual Review of Pathology: Mechanisms of Disease

29 August 2017

published in

1 reference

29 August 2017

volume

9

1 reference

29 August 2017

page(s)

47-71

1 reference

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

29 August 2017

cites work

1 reference

24 May 2022

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Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells

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5 June 2022

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Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR.

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12 October 2022

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Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells

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12 October 2022

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The role of hypoxia in recurrence following resection of Dukes' B colorectal cancer

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Overexpression of intrinsic hypoxia markers HIF1alpha and CA-IX predict for local recurrence in stage T1-T2 glottic laryngeal carcinoma treated with radiotherapy.

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Impaired Ca(2+)-handling in HIF-1alpha(+/-) mice as a consequence of pressure overload

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Immunosuppressive networks in the tumour environment and their therapeutic relevance

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Generation of a mouse model of Von Hippel-Lindau kidney disease leading to renal cancers by expression of a constitutively active mutant of HIF1α.

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Time to treatment in primary percutaneous coronary intervention

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Regulation of metabolism by hypoxia-inducible factor 1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Adenoviral transfer of HIF-1alpha enhances vascular responses to critical limb ischemia in diabetic mice

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia inducible factor 1α and hypoxia inducible factor 2α play distinct and functionally overlapping roles in oral squamous cell carcinoma.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

VEGF exerts an angiogenesis-independent function in cancer cells to promote their malignant progression

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Influence of coronary collateral vessels on myocardial infarct size in humans. Results of phase I thrombolysis in myocardial infarction (TIMI) trial. The TIMI Investigators

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

HIF-1-mediated activation of telomerase in cervical cancer cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Therapeutic angiogenesis and vasculogenesis for ischemic disease: part II: cell-based therapies

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

The role of hypoxia-inducible factor 1 in atherosclerosis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Expression of hypoxia-inducible factor (HIF)-1alpha and vascular endothelial growth factor (VEGF)-D as outcome predictors in resected esophageal squamous cell carcinoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor-1α protein expression is associated with poor survival in normal karyotype adult acute myeloid leukemia.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

The HIF1A C85T single nucleotide polymorphism influences the number of branches of the human coronary tree

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Involvement of hypoxia-inducible factor-1 in the inflammatory responses of human LAD2 mast cells and basophils

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Overexpression of hypoxia-inducible factor HIF-1alpha predicts early relapse in breast cancer: retrospective study in a series of 745 patients

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia inducible factor-1alpha is a prognostic marker in premenopausal patients with intermediate to highly differentiated breast cancer but not a predictive marker for tamoxifen response

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia promotes tumor growth in linking angiogenesis to immune escape

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Collagen reorganization at the tumor-stromal interface facilitates local invasion

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1alpha in cancer: role of free radical formation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Constitutively active HIF-1alpha improves perfusion and arterial remodeling in an endovascular model of limb ischemia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

An association between collateral blood flow and myocardial viability in patients with recent myocardial infarction

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor-1 alpha in non small cell lung cancer: relation to growth factor, protease and apoptosis pathways

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Mechanisms of cell death in heart disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Effect of hypoxia-inducible factor-1alpha gene therapy on walking performance in patients with intermittent claudication.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Glucose for the aging heart?

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

NCEP-Defined Metabolic Syndrome, Diabetes, and Prevalence of Coronary Heart Disease Among NHANES III Participants Age 50 Years and Older

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Bone-marrow-derived cells for enhancing collateral development: mechanisms, animal data, and initial clinical experiences

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Ischemia and reperfusion--from mechanism to translation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor–dependent breastcancer–mesenchymal stem cell bidirectional signaling promotesmetastasis.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor 1alpha/vascular endothelial growth factor axis in astrocytomas. Associations with microvessel morphometry, proliferation and prognosis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Targeting the hypoxia-adenosinergic signaling pathway to improve the adoptive immunotherapy of cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Attenuation of proteasome-induced proteolysis in skeletal muscle by {beta}-hydroxy-{beta}-methylbutyrate in cancer-induced muscle loss

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Tackling heart failure in the twenty-first century

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

HIF-1alpha overexpression and experimental murine atherosclerosis.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

RNA interference for HIF-1alpha inhibits foam cells formation in vitro

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Combined analysis of hypoxia-inducible factor 1 alpha and metallothionein indicates an aggressive subtype of colorectal carcinoma.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Cancer without disease.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Digoxin inhibits development of hypoxic pulmonary hypertension in mice

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Partial HIF-1alpha deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Digoxin inhibits retinal ischemia-induced HIF-1alpha expression and ocular neovascularization

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Ranibizumab for neovascular age-related macular degeneration

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Significant correlation of hypoxia-inducible factor-1alpha with treatment outcome in cervical cancer treated with radical radiotherapy

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor 1alpha polymorphism and coronary collaterals in patients with ischemic heart disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Age-dependent impairment of HIF-1alpha expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Lower mortality from coronary heart disease and stroke at higher altitudes in Switzerland.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Intermittent hypoxia degrades HIF-2alpha via calpains resulting in oxidative stress: implications for recurrent apnea-induced morbidities.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Impaired angiogenesis and mobilization of circulating angiogenic cells in HIF-1alpha heterozygous-null mice after burn wounding

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Metabolic reprogramming by HIF-1 promotes the survival of bone marrow-derived angiogenic cells in ischemic tissue

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca2+ in pulmonary arterial smooth muscle cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: its impact on prognosis and on neoangiogenesis.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Prognostic significance of Hypoxia-Inducible Factor 1 alpha(HIF-1 alpha) expression in serous ovarian cancer: an immunohistochemical study

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Lymphangiogenesis and lymphatic metastasis in breast cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Evaluation of hypoxia-inducible factor 1alpha overexpression as a predictor of tumour recurrence and progression in superficial urothelial bladder carcinoma.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Effect of episodic hypoxia on sympathetic activity and blood pressure

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Myocardial reperfusion: a double-edged sword?

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-β signaling

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Human cancers converge at the HIF-2alpha oncogenic axis.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor 1 alpha expression correlates with angiogenesis and unfavorable prognosis in bladder cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Expression of hypoxia-inducible factor 1alpha, hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: nuclear expression of hypoxia-inducible factor 1alpha is an ind

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Tumor hypoxia and malignant progression.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

The synergism of age and db/db genotype impairs wound healing

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

HIF-dependent antitumorigenic effect of antioxidants in vivo

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor-1alpha and -2alpha are expressed in most rectal cancers but only hypoxia-inducible factor-1alpha is associated with prognosis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-Inducible Factor-1 Expression Predicts a Poor Response to Primary Chemoendocrine Therapy and Disease-Free Survival in Primary Human Breast Cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Chronic lung allograft rejection and airway microvasculature: is HIF-1 the missing link?

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Detection and characterization of tumor hypoxia using pO2 histography

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Sustained expression of Hif-1alpha in the diabetic environment promotes angiogenesis and cutaneous wound repair

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Hypoxia-inducible factor-1alpha expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro-oesophageal adenocarcinomas

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Purification and characterization of hypoxia-inducible factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV-PATHOL-012513-104720

Identifiers

DOI

10.1146/ANNUREV-PATHOL-012513-104720

1 reference

29 August 2017

1 reference