(Q27696899)

https://api.crossref.org/works/10.1038%2FNATURE14035

Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Discovery and development of orexin receptor antagonists as therapeutics for insomnia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Hypocretin (orexin) deficiency in human narcolepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Structure of a beta1-adrenergic G-protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Crystallizing membrane proteins for structure determination: use of lipidic mesophases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Structure of the agonist-bound neurotensin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Crystal structure of an archaeal glycogen synthase: insights into oligomerization and substrate binding of eukaryotic glycogen synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Mapping the binding pocket of dual antagonist almorexant to human orexin 1 and orexin 2 receptors: comparison with the selective OX1 antagonist SB-674042 and the selective OX2 antagonist N-ethyl-2-[(6-methoxy-pyridin-3-yl)-(toluene-2-sulfonyl)-amino

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Structure and dynamics of the M3 muscarinic acetylcholine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Activation and allosteric modulation of a muscarinic acetylcholine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Conformational analysis of N,N-disubstituted-1,4-diazepane orexin receptor antagonists and implications for receptor binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Structure-based discovery of beta2-adrenergic receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Promotion of sleep by targeting the orexin system in rats, dogs and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Chimeric, mutant orexin receptors show key interactions between orexin receptors, peptides and antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Amino and carboxyl terminal modifications to facilitate the production and purification of a G protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Crystallizing membrane proteins using lipidic mesophases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Phasercrystallographic software

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

PHENIX: a comprehensive Python-based system for macromolecular structure solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Fitting molecular fragments into electron density

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Features and development of Coot

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

MolProbity: all-atom structure validation for macromolecular crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Automated docking screens: a feasibility study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Rapid context-dependent ligand desolvation in molecular docking

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

Comparative performance assessment of the conformational model generators omega and catalyst: a large-scale survey on the retrieval of protein-bound ligand conformations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035

DSX: a knowledge-based scoring function for the assessment of protein-ligand complexes

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25533960

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Extending the Applicability of the Nonlinear Poisson−Boltzmann Equation: Multiple Dielectric Constants and Multivalent Ions†

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14035