(Q27697610)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

James E Audia

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Hykop Gevorkyan

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Dustin J Mergott

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

author name string

Patrick C May

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Stephen L Lowe

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Robert A Dean

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Scott A Monk

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Patrick J Cocke

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Leonard N Boggs

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Anthony R Borders

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Richard A Brier

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

David O Calligaro

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Theresa A Day

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Larry Ereshefsky

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Jon A Erickson

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Celedon R Gonzales

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Douglas E James

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Stanford S Jhee

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Steven F Komjathy

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Linglin Li

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Terry D Lindstrom

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Brian M Mathes

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Ferenc Martényi

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Scott M Sheehan

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Stephanie L Stout

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

David E Timm

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Grant M Vaught

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Brian M Watson

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Leonard L Winneroski

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Zhixiang Yang

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

language of work or name

English

0 references

publication date

1 January 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

published in

Journal of Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

volume

35

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

page(s)

1199-1210

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

28 February 2020

cites work

1 reference

12 December 2020

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

12 December 2020

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

12 December 2020

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

12 December 2020

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

1 reference

12 December 2020

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

1 reference

12 December 2020

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

1 reference

12 December 2020

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

12 December 2020

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

12 December 2020

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

1 reference

12 December 2020

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

1 reference

12 December 2020

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

12 December 2020

Control of peripheral nerve myelination by the beta-secretase BACE1

1 reference

12 December 2020

Bace1 modulates myelination in the central and peripheral nervous system.

1 reference

12 December 2020

Validation of 96-well equilibrium dialysis with non-radiolabeled drug for definitive measurement of protein binding and application to clinical development of highly-bound drugs

1 reference

12 December 2020

Overview of the CCP4 suite and current developments

1 reference

12 December 2020

Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass

1 reference

12 December 2020

Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor

1 reference

12 December 2020

The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb

1 reference

12 December 2020

The precision of axon targeting of mouse olfactory sensory neurons requires the BACE1 protease

1 reference

12 December 2020

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

1 reference

12 December 2020

Validation of a multiplex assay for simultaneous quantification of amyloid-β peptide species in human plasma with utility for measurements in studies of Alzheimer's disease therapeutics.

1 reference

12 December 2020

β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects

1 reference

12 December 2020

BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells

1 reference

12 December 2020

Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles

1 reference

12 December 2020

Targeting the β secretase BACE1 for Alzheimer's disease therapy

1 reference

12 December 2020

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

1 reference

12 December 2020

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1 reference

12 December 2020

10.1523/JNEUROSCI.4129-14.2015

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

3045185

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

3045185

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609634%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

PubMed publication ID

25609634

2 references

Consolidated OpenCitations Corpus – April 2017

3045185