(Q36385744)

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β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects

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13 February 2020

β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects (English)

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13 February 2020

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William A Eimer

4

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13 February 2020

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Brian Hitt

1

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13 February 2020

Sean M Riordan

2

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13 February 2020

Lokesh Kukreja

3

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13 February 2020

Tharinda W Rajapaksha

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13 February 2020

Robert Vassar

6

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13 February 2020

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17 September 2012

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13 February 2020

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18

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Journal of Biological Chemistry

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13 February 2020

287

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13 February 2020

46

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13 February 2020

38408-38425

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13 February 2020

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3493884/fullTextXML

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

1 reference

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Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

1 reference

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30 September 2017

The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo

1 reference

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The precision of axon targeting of mouse olfactory sensory neurons requires the BACE1 protease

1 reference

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The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb

1 reference

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30 September 2017

BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization

1 reference

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30 September 2017

BACE1 deficiency causes altered neuronal activity and neurodegeneration

1 reference

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30 September 2017

ADAM8 is a negative regulator of retinal neovascularization and of the growth of heterotopically injected tumor cells in mice

1 reference

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30 September 2017

Identification of beta-secretase (BACE1) substrates using quantitative proteomics

1 reference

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30 September 2017

The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential

1 reference

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30 September 2017

Synaptic activity prompts gamma-secretase-mediated cleavage of EphA4 and dendritic spine formation

1 reference

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30 September 2017

A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.

1 reference

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30 September 2017

ADAM9 is involved in pathological retinal neovascularization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493884

30 September 2017

Ephrin-B3 reverse signaling through Grb4 and cytoskeletal regulators mediates axon pruning

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493884

30 September 2017

L1 and NCAM adhesion molecules as signaling coreceptors in neuronal migration and process outgrowth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493884

30 September 2017

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

1 reference

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30 September 2017

Control of peripheral nerve myelination by the beta-secretase BACE1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493884

30 September 2017

BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493884

30 September 2017

L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth

1 reference

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30 September 2017

Learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice

1 reference

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30 September 2017

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

1 reference

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Mechanisms of retinotopic map development: Ephs, ephrins, and spontaneous correlated retinal activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493884

30 September 2017

Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493884

30 September 2017

Cis and trans interactions of L1 with neuropilin-1 control axonal responses to semaphorin 3A.

1 reference

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30 September 2017

Misguided axonal projections, neural cell adhesion molecule 180 mRNA upregulation, and altered behavior in mice deficient for the close homolog of L1

1 reference

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gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

1 reference

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30 September 2017

Structure and emergence of specific olfactory glomeruli in the mouse

1 reference

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30 September 2017

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

1 reference

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30 September 2017

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

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30 September 2017

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493884

30 September 2017

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

1 reference

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30 September 2017

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

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1 reference

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1 reference

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1 reference

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Beta-amyloid precursor protein cleavage by a membrane-bound protease

1 reference

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

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L1 knockout mice show dilated ventricles, vermis hypoplasia and impaired exploration patterns.

1 reference

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1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415505

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1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415505

21 January 2018

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1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415505

21 January 2018

Bace1 modulates myelination in the central and peripheral nervous system.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415505

21 January 2018

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415505

21 January 2018

Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415505

21 January 2018

Abnormal axonal guidance and brain anatomy in mouse mutants for the cell recognition molecules close homolog of L1 and NgCAM-related cell adhesion molecule.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415505

21 January 2018

EphA4 signaling in juveniles establishes topographic specificity of structural plasticity in the hippocampus

1 reference

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21 January 2018

Eph-ephrin promiscuity is now crystal clear

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415505

21 January 2018

beta-Secretase expression in normal and functionally deprived rat olfactory bulbs: inverse correlation with oxidative metabolic activity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415505

21 January 2018

Close homolog of L1 and neuropilin 1 mediate guidance of thalamocortical axons at the ventral telencephalon.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415505

21 January 2018

Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415505

21 January 2018

CHL1 promotes Sema3A-induced growth cone collapse and neurite elaboration through a motif required for recruitment of ERM proteins to the plasma membrane.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493884

21 September 2018

Abnormalities in neuronal process extension, hippocampal development, and the ventricular system of L1 knockout mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493884

21 September 2018

The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415505

21 January 2018

Analysis of the L1-deficient mouse phenotype reveals cross-talk between Sema3A and L1 signaling pathways in axonal guidance

1 reference

https://pubmed.ncbi.nlm.nih.gov/22988240

12 December 2020

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10.1074/JBC.M112.415505

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22988240%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22988240%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22988240%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

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