(Q27703745)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26822609%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

title

2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26822609%20AND%20SRC:MED&resulttype=core&format=json

cryogenic electron microscopy

6 March 2020

main subject

0 references

Valosin containing protein

1 reference

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Raymond J. Deshaies

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26822609%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Donna Huryn

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26822609%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Sriram Subramaniam

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26822609%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

author name string

Soojay Banerjee

1

1 reference

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6 March 2020

Alberto Bartesaghi

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26822609%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Alan Merk

3

1 reference

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6 March 2020

Prashant Rao

4

1 reference

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6 March 2020

Stacie L Bulfer

5

1 reference

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6 March 2020

Yongzhao Yan

6

1 reference

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6 March 2020

Neal Green

7

1 reference

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6 March 2020

Barbara Mroczkowski

8

1 reference

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6 March 2020

R Jeffrey Neitz

9

1 reference

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6 March 2020

Veronica Falconieri

11

1 reference

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6 March 2020

Jacqueline L S Milne

13

1 reference

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6 March 2020

Michelle Arkin

15

1 reference

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6 March 2020

Peter Wipf

10

1 reference

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6 March 2020

language of work or name

English

0 references

publication date

28 January 2016

1 reference

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6 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26822609%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

volume

351

1 reference

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6 March 2020

page(s)

871-875

1 reference

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6 March 2020

issue

6275

1 reference

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AAA+ superfamily ATPases: common structure--diverse function

6 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAD7974

Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAD7974

Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAD7974

Structural Basis for Ovarian Tumor Domain-containing Protein 1 (OTU1) Binding to p97/Valosin-containing Protein (VCP)

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAD7974

Hierarchical binding of cofactors to the AAA ATPase p97

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAD7974

Structural basis of the interaction between the AAA ATPase p97/VCP and its adaptor protein p47

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAD7974

Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAD7974

Structure of the AAA ATPase p97

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAD7974

A novel ATP-dependent conformation in p97 N–D1 fragment revealed by crystal structures of disease-related mutants

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAD7974

Conformational changes in the AAA ATPase p97-p47 adaptor complex

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAD7974

2.2 Å resolution cryo-EM structure of β-galactosidase in complex with a cell-permeant inhibitor

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAD7974

AAA+ proteins: have engine, will work

21 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD7974

Quantifying the local resolution of cryo-EM density maps

21 April 2017

1 reference

12 December 2020

Inter-ring rotations of AAA ATPase p97 revealed by electron cryomicroscopy.

1 reference

12 December 2020

Clipping or Extracting: Two Ways to Membrane Protein Degradation

1 reference

12 December 2020

Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine

1 reference

12 December 2020

SUMOylation of the brain-predominant Ataxin-3 isoform modulates its interaction with p97.

1 reference

12 December 2020

Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy

1 reference

12 December 2020

Alkylsulfanyl-1,2,4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships

1 reference

12 December 2020

ATP binding to p97/VCP D1 domain regulates selective recruitment of adaptors to its proximal N-domain

1 reference

12 December 2020

Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97.

1 reference

12 December 2020

Development of p97 AAA ATPase inhibitors

1 reference

12 December 2020

Sorafenib-mediated targeting of the AAA⁺ ATPase p97/VCP leads to disruption of the secretory pathway, endoplasmic reticulum stress, and hepatocellular cancer cell death

1 reference

12 December 2020

The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis.

1 reference

12 December 2020

Inhibitors of the AAA+ chaperone p97

1 reference

12 December 2020

High-speed atomic force microscopic observation of ATP-dependent rotation of the AAA+ chaperone p97.

1 reference

12 December 2020

The role of the N-domain in the ATPase activity of the mammalian AAA ATPase p97/VCP.

1 reference

12 December 2020

Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase

1 reference

12 December 2020

Mitochondrial function in neuronal cells depends on p97/VCP/Cdc48-mediated quality control

1 reference

12 December 2020

A Fragment-Based Ligand Screen Against Part of a Large Protein Machine: The ND1 Domains of the AAA+ ATPase p97/VCP.

1 reference

12 December 2020

Cytosolic ATPases, p97 and NSF, are sufficient to mediate rapid membrane fusion

1 reference

12 December 2020

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

1 reference

12 December 2020

Withaferin A Analogs That Target the AAA+ Chaperone p97.

1 reference

12 December 2020

Evaluating p97 inhibitor analogues for their domain selectivity and potency against the p97-p47 complex

1 reference

12 December 2020

Critical role of VCP/p97 in the pathogenesis and progression of non-small cell lung carcinoma

1 reference

12 December 2020

Identifiers

DOI

10.1126/SCIENCE.AAD7974

2 references

Consolidated OpenCitations Corpus – April 2017

1891453

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26822609%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1891453

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26822609%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

2 references

Consolidated OpenCitations Corpus – April 2017

1891453