(Q27851952)

13 November 2016

title

Elucidating distinct roles for NF1 in melanomagenesis (English)

1 reference

PubMed

PubMed publication ID

13 November 2016

Zachary A Cooper

5

0 references

Richard Marais

Richard Marais

12

0 references

Keith Flaherty

10

Keith Flaherty

0 references

Ludwine Messiaen

6

Ludwine Messiaen

0 references

Jennifer Wargo

11

Jennifer A Wargo

0 references

Roderick Bronson

7

Roderick T Bronson

0 references

Karen Cichowski

13

Karen Cichowski

0 references

author name string

Ophélia Maertens

1

0 references

Bryan Johnson

2

0 references

Pablo Hollstein

3

0 references

Dennie T Frederick

4

0 references

Martin McMahon

8

0 references

Scott Granter

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

9

0 references

publication date

March 2013

0 references

1 reference

3

0 references

issue

3

0 references

page(s)

338-49

0 references

cites work

1 reference

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20 March 2017

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20 March 2017

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Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

20 March 2017

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20 March 2017

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Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

20 March 2017

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20 March 2017

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Somatic mutations affect key pathways in lung adenocarcinoma

20 March 2017

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CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations

20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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Chemokine signaling via the CXCR2 receptor reinforces senescence

20 March 2017

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20 March 2017

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Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain

20 March 2017

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

20 March 2017

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RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

7 April 2017

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Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K

7 April 2017

1 reference

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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

7 April 2017

1 reference

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

7 April 2017

1 reference

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

7 April 2017

1 reference

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BRAFE600-associated senescence-like cell cycle arrest of human naevi

7 April 2017

1 reference

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Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

Targeting the RAS pathway in melanoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

The essence of senescence

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

Oncogenic Braf induces melanocyte senescence and melanoma in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

Braf(V600E) cooperates with Pten loss to induce metastatic melanoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

Modeling genomic diversity and tumor dependency in malignant melanoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

Many roads lead to oncogene-induced senescence

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

TORC1 is essential for NF1-associated malignancies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

Ras and phosphoinositide 3-kinase: partners in development and tumorigenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

GAPs in growth factor signalling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

The NF1 tumor suppressor critically regulates TSC2 and mTOR.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

High frequency of BRAF mutations in nevi

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

Senescence of human fibroblasts induced by oncogenic Raf.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

Mutations of critical amino acids affect the biological and biochemical properties of oncogenic A-Raf and Raf-1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

Cellular senescence in naevi and immortalisation in melanoma: a role for p16?

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

A negative feedback signaling network underlies oncogene-induced senescence

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

Proteomic analysis reveals hyperactivation of the mammalian target of rapamycin pathway in neurofibromatosis 1-associated human and mouse brain tumors

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

Exhaustive mutation analysis of the NF1 gene allows identification of 95% of mutations and reveals a high frequency of unusual splicing defects.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595355

Spectrum of single- and multiexon NF1 copy number changes in a cohort of 1,100 unselected NF1 patients

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23171796

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Characterization of melanocyte-specific inducible Cre recombinase transgenic mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23171796