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Trastuzumab-resistant cells rely on a HER2-PI3K-FoxO-survivin axis and are sensitive to PI3K inhibitors
scientific article
Trastuzumab-Resistant Cells Rely on a HER2-PI3K-FoxO-Survivin Axis and Are Sensitive to PI3K Inhibitors
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scholarly article
1 reference
stated in
PubMed
PubMed ID
23204226
retrieved
13 November 2016
title
Trastuzumab-resistant cells rely on a HER2-PI3K-FoxO-survivin axis and are sensitive to PI3K inhibitors
(English)
1 reference
stated in
PubMed
PubMed ID
23204226
retrieved
13 November 2016
main subject
pilaralisib
1 reference
stated in
ChEBI release 2020-05-28
ChEBI ID
71957
author
Carlos L Arteaga
series ordinal
8
object named as
Carlos L Arteaga
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author name string
Anindita Chakrabarty
series ordinal
1
0 references
Neil E Bhola
series ordinal
2
0 references
Cammie Sutton
series ordinal
3
0 references
Ritwik Ghosh
series ordinal
4
0 references
María Gabriela Kuba
series ordinal
5
0 references
Bhuvanesh Dave
series ordinal
6
0 references
Jenny C Chang
series ordinal
7
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language of work or name
English
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publication date
1 February 2013
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published in
Cancer Research
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volume
73
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page(s)
1190-200
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issue
3
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PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.
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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
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Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature
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Improving treatment of HER2-positive cancers: opportunities and challenges
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29 September 2017
Beyond trastuzumab: novel therapeutic strategies in HER2-positive metastatic breast cancer
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29 September 2017
The receptor tyrosine kinase ErbB3 maintains the balance between luminal and basal breast epithelium
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FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer.
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Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors
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29 September 2017
PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs
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29 September 2017
AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity
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Broad spectrum and potent antitumor activities of YM155, a novel small-molecule survivin suppressant, in a wide variety of human cancer cell lines and xenograft models
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29 September 2017
Loss of phosphatase and tensin homolog or phosphoinositol-3 kinase activation and response to trastuzumab or lapatinib in human epidermal growth factor receptor 2-overexpressing locally advanced breast cancers
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29 September 2017
Targeting breast cancer stem cells
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29 September 2017
H1047R phosphatidylinositol 3-kinase mutant enhances HER2-mediated transformation by heregulin production and activation of HER3
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29 September 2017
Endogenous tumor suppression mediated by PTEN involves survivin gene silencing.
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Tumor-initiating cells of HER2-positive carcinoma cell lines express the highest oncoprotein levels and are sensitive to trastuzumab
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Repression of BIRC5/survivin by FOXO3/FKHRL1 sensitizes human neuroblastoma cells to DNA damage-induced apoptosis
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A functional Notch-survivin gene signature in basal breast cancer
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29 September 2017
Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235.
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29 September 2017
A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy
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29 September 2017
HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion.
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29 September 2017
Human breast cancer cells selected for resistance to trastuzumab in vivo overexpress epidermal growth factor receptor and ErbB ligands and remain dependent on the ErbB receptor network
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PubMed Central
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29 September 2017
Requirements for survivin in terminal differentiation of erythroid cells and maintenance of hematopoietic stem and progenitor cells
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29 September 2017
Trastuzumab: triumphs and tribulations
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29 September 2017
The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis
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29 September 2017
Intranuclear 3'-phosphoinositide metabolism and Akt signaling: new mechanisms for tumorigenesis and protection against apoptosis?
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29 September 2017
Survivin expression in breast cancer predicts clinical outcome and is associated with HER2, VEGF, urokinase plasminogen activator and PAI-1.
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29 September 2017
CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK)
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29 September 2017
Tumor suppressor Foxo3a is involved in the regulation of lipopolysaccharide-induced interleukin-8 in intestinal HT-29 cells
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2 June 2018
Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization
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2 June 2018
Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action
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2 June 2018
Survivin, cancer networks and pathway-directed drug discovery.
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27 November 2018
Tumour biology: herceptin acts as an anti-angiogenic cocktail.
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27 November 2018
Identifiers
DOI
10.1158/0008-5472.CAN-12-2440
1 reference
stated in
PubMed
PubMed ID
23204226
retrieved
13 November 2016
PMCID
3563941
1 reference
stated in
PubMed
PubMed ID
23204226
retrieved
13 November 2016
PubMed ID
23204226
1 reference
stated in
PubMed
PubMed ID
23204226
retrieved
13 November 2016
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