(Q27853330)

13 November 2016

title

Targeting the mTOR Complex by Everolimus in NRAS Mutant Neuroblastoma (English)

1 reference

13 November 2016

1 reference

9

Gerhard Rogler

Gerhard

Rogler

1 reference

Alessandra Curioni-Fontecedro

20 October 2023

2

object named as

Alessandra Curioni-Fontecedro

Alessandra

Curioni-Fontecedro

1 reference

20 October 2023

8

John M

Maris

John M Maris

1 reference

20 October 2023

Michael K Kiessling

1

Michael K

Kiessling

1 reference

20 October 2023

Panagiotis Samaras

3

Panagiotis

Samaras

1 reference

20 October 2023

Silvia Lang

4

Silvia

Lang

1 reference

20 October 2023

Michael Scharl

5

Michael

Scharl

1 reference

20 October 2023

Adriano Aguzzi

6

Adriano

Aguzzi

1 reference

20 October 2023

Derek A Oldrige

7

Derek A

Oldrige

1 reference

Creative Commons Attribution 4.0 International

20 October 2023

language of work or name

English

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publication date

2016

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published in

PLOS One

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volume

11

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issue

1

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page(s)

e0147682

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copyright license

start time

28 January 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo

1 reference

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MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study

20 March 2017

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Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731059

Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731059

A landscape of driver mutations in melanoma

20 March 2017

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Improved survival with vemurafenib in melanoma with BRAF V600E mutation

20 March 2017

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Frequencies of BRAF and NRAS mutations are different in histological types and sites of origin of cutaneous melanoma: a meta-analysis

20 March 2017

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Activating mutations in ALK provide a therapeutic target in neuroblastoma

20 March 2017

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RAS oncogenes: weaving a tumorigenic web

20 March 2017

1 reference

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Characteristics of lung cancers harboring NRAS mutations

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731059

Drug combination studies and their synergy quantification using the Chou-Talalay method

20 March 2017

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Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731059

Antitumor activity in RAS-driven tumors by blocking AKT and MEK.

29 September 2017

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Neuroblastoma: molecular pathogenesis and therapy

29 September 2017

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Drugging the undruggable RAS: Mission possible?

29 September 2017

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Mutant NRASQ61 shares signaling similarities across various cancer types--potential implications for future therapies.

29 September 2017

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Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731059

Phase II trial of MEK inhibitor selumetinib (AZD6244, ARRY-142886) in patients with BRAFV600E/K-mutated melanoma.

29 September 2017

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The genetic landscape of high-risk neuroblastoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731059

Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731059

High-throughput mutation profiling of CTCL samples reveals KRAS and NRAS mutations sensitizing tumors toward inhibition of the RAS/RAF/MEK signaling cascade.

29 September 2017

1 reference

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AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in precl

29 September 2017

1 reference

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Up-regulation of Bak and Bim via JNK downstream pathway in the response to nitric oxide in human glioblastoma cells

29 September 2017

1 reference

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AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731059

Recent advances in neuroblastoma

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0147682

Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0147682

Phase I study of everolimus in pediatric patients with refractory solid tumors

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0147682

10.1371/JOURNAL.PONE.0147682

21 January 2018

Identifiers

DOI

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1 reference

13 November 2016

1 reference