(Q27938700)

1 December 2016

title

Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples Its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase (English)

1 reference

(D)-2-hydroxyglutarate-pyruvate transhydrogenase activity

1 December 2016

0 references

Saccharomyces cerevisiae

0 references

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0099615

alpha-ketoglutarate reductase activity

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0061759

Phosphoglycerate dehydrogenase SER33 YIL074C

1 reference

D-lactate dehydrogenase YDL178W

1 reference

Phosphoglycerate dehydrogenase SER3 YER081W

1 reference

D-lactate dehydrogenase YDL174C

1 reference

D-lactate dehydrogenase YEL071W

1 reference

author

Cedric Guignard

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26774271%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Paul P Jung

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26774271%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

author name string

Julia Becker-Kettern

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26774271%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Nicole Paczia

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26774271%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Jean-François Conrotte

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26774271%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Daniel P Kay

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26774271%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Carole L Linster

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26774271%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

11 June 2020

language of work or name

English

0 references

publication date

18 March 2016

0 references

published in

2 references

1 December 2016

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26774271%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

volume

291

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26774271%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

issue

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26774271%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

page(s)

6036-6058

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26774271%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

11 June 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4813551/fullTextXML

inferred from PubMed Central ID database lookup

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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7 April 2017

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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

7 April 2017

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7 April 2017

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7 April 2017

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2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling

29 September 2017

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29 September 2017

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Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate.

29 September 2017

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MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis.

29 September 2017

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29 September 2017

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What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

29 September 2017

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29 September 2017

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D-Lactate production as a function of glucose metabolism in Saccharomyces cerevisiae

29 September 2017

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29 September 2017

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IDH1 and IDH2 have critical roles in 2-hydroxyglutarate production in D-2-hydroxyglutarate dehydrogenase depleted cells

29 September 2017

1 reference

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29 September 2017

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Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

29 September 2017

1 reference

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Expansion of hexose transporter genes was associated with the evolution of aerobic fermentation in yeasts

29 September 2017

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29 September 2017

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Gene duplication and the evolution of ribosomal protein gene regulation in yeast

29 September 2017

1 reference

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Novel insights into L-2-hydroxyglutaric aciduria: mass isotopomer studies reveal 2-oxoglutaric acid as the metabolic precursor of L-2-hydroxyglutaric acid

29 September 2017

1 reference

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L-2-hydroxyglutaric aciduria, a defect of metabolite repair

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813551

A suite of Gateway cloning vectors for high-throughput genetic analysis in Saccharomyces cerevisiae

29 September 2017

1 reference

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Mitochondrial retrograde signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813551

Identification of the gene encoding hydroxyacid-oxoacid transhydrogenase, an enzyme that metabolizes 4-hydroxybutyrate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813551

Investigations by mass isotopomer analysis of the formation of D-2-hydroxyglutarate by cultured lymphoblasts from two patients with D-2-hydroxyglutaric aciduria

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813551

Tor1/2 regulation of retrograde gene expression in Saccharomyces cerevisiae derives indirectly as a consequence of alterations in ammonia metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813551

Regulation of the Saccharomyces cerevisiae DLD1 gene encoding the mitochondrial protein D-lactate ferricytochrome c oxidoreductase by HAP1 and HAP2/3/4/5.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813551

The Archaeoglobus fulgidus D-lactate dehydrogenase is a Zn(2+) flavoprotein.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813551

L-2-Hydroxyglutaric aciduria: an inborn error of metabolism?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813551

Formation of α-Hydroxyglutaric Acid by Aspergillus glaucus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813551

Genetic and physiological control of serine and glycine biosynthesis in Saccharomyces

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813551

Glucose-fructose oxidoreductase, a new enzyme isolated from Zymomonas mobilis that is responsible for sorbitol production

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813551

Multiple Turnovers of the Nicotino-Enzyme PdxB Require α-Keto Acids as Cosubstrates

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813551

Evolutionary history of D-lactate dehydrogenases: a phylogenomic perspective on functional diversity in the FAD binding oxidoreductase/transferase type 4 family

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813551

Stable-isotope dilution analysis of D- and L-2-hydroxyglutaric acid: application to the detection and prenatal diagnosis of D- and L-2-hydroxyglutaric acidemias

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813551

Low molecular weight organic acids in the urine of the newborn

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813551

Measurement of urinary D- and L-2-hydroxyglutarate enantiomers by stable-isotope-dilution liquid chromatography-tandem mass spectrometry after derivatization with diacetyl-L-tartaric anhydride

2 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.704494

CYCLoPs: A Comprehensive Database Constructed from Automated Analysis of Protein Abundance and Subcellular Localization Patterns in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.704494

Engineering cellular redox balance in Saccharomyces cerevisiae for improved production of L-lactic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.704494

Exploring the functional landscape of gene expression: directed search of large microarray compendia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.704494

Metabolic consequences of altered phosphoenolpyruvate carboxykinase activity in Corynebacterium glutamicum reveal anaplerotic regulation mechanisms in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.704494

Whole-exome sequencing detects somatic mutations of IDH1 in metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria (MC-HGA).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.704494

Propionate metabolism in Saccharomyces cerevisiae: implications for the metabolon hypothesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.704494

D-2-hydroxyglutaric aciduria: case report and biochemical studies

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813551

Distribution of 14C-labelled carbon from glucose and glutamate during anaerobic growth of Saccharomyces cerevisiae

27 November 2018

1 reference

12 December 2020

Phylogenetic relationships among yeasts of the ? complex? determined from multigene sequence analyses

1 reference

12 December 2020

Role of yeast JmjC-domain containing histone demethylases in actively transcribed regions

1 reference

12 December 2020

A spectrophotometric procedure for determining the activity of various rat tissue oxidases

1 reference

12 December 2020

Functional analyses of PAU genes in Saccharomyces cerevisiae

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M115.704494

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26774271%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26774271%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

2 references

1 December 2016