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The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation
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title
The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation
(English)
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stated in
PubMed
author name string
Kankana Bardhan
series ordinal
1
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stated in
Crossref
Theodora Anagnostou
series ordinal
2
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Vassiliki A. Boussiotis
series ordinal
3
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Crossref
language of work or name
English
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stated in
PubMed
publication date
12 December 2016
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stated in
PubMed
published in
Frontiers in Immunology
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volume
7
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PubMed
page(s)
550
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PubMed
cites work
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
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Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production
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PubMed Central
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Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
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Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction
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RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs
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PubMed Central
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CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
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PubMed Central
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Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
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Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target
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Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras
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Posttranscriptional control of T cell effector function by aerobic glycolysis
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Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
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The PD-1 pathway in tolerance and autoimmunity
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The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice
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Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
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Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling
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Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer
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20 March 2017
Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials
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The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures
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PD-1 Expression in Acute Hepatitis C Virus (HCV) Infection Is Associated with HCV-Specific CD8 Exhaustion
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20 March 2017
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors
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Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2
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Nivolumab plus ipilimumab in advanced melanoma
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PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma.
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Control of regulatory T cell development by the transcription factor Foxp3
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Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in Melanoma
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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
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20 March 2017
Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer
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Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
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PD-1 and its ligands in tolerance and immunity
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Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
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The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
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Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses
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Expression of programmed death 1 ligands by murine T cells and APC
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A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans
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PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2
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PD-L2 is a second ligand for PD-1 and inhibits T cell activation
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Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice
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Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
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Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling
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20 March 2017
Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways
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20 March 2017
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20 March 2017
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma
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7 April 2017
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7 April 2017
Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer
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7 April 2017
Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer
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7 April 2017
Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
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7 April 2017
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7 April 2017
Pembrolizumab versus Ipilimumab in Advanced Melanoma
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7 April 2017
PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma
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7 April 2017
PD-1 blockade induces responses by inhibiting adaptive immune resistance
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7 April 2017
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
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7 April 2017
MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
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7 April 2017
Nivolumab in previously untreated melanoma without BRAF mutation
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7 April 2017
Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial
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7 April 2017
Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab
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7 April 2017
Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
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7 April 2017
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7 April 2017
T cell exhaustion
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7 April 2017
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates
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7 April 2017
Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma
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7 April 2017
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
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7 April 2017
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
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7 April 2017
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
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24 May 2017
Combined nivolumab and ipilimumab versus ipilimumab alone in patients with advanced melanoma: 2-year overall survival outcomes in a multicentre, randomised, controlled, phase 2 trial
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29 September 2017
Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality
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retrieved
29 September 2017
Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial
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PubMed Central
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29 September 2017
Programmed death-1 controls T cell survival by regulating oxidative metabolism.
1 reference
stated in
PubMed Central
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29 September 2017
Overall Survival and Long-Term Safety of Nivolumab (Anti-Programmed Death 1 Antibody, BMS-936558, ONO-4538) in Patients With Previously Treated Advanced Non-Small-Cell Lung Cancer
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PubMed Central
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29 September 2017
PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial.
1 reference
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PubMed Central
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29 September 2017
Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
Nivolumab for Metastatic Renal Cell Carcinoma: Results of a Randomized Phase II Trial
1 reference
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PubMed Central
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29 September 2017
Therapeutic uses of anti-PD-1 and anti-PD-L1 antibodies
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, phase 2 trial
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or -naive melanoma
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: results of an international phase II trial
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
PD-1 increases PTEN phosphatase activity while decreasing PTEN protein stability by inhibiting casein kinase 2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
Notch signaling regulates PD-1 expression during CD8(+) T-cell activation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
Cancer immunology--analysis of host and tumor factors for personalized medicine
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
IFN-α directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
PD-1/PD-L1 pathway and T-cell exhaustion in chronic hepatitis virus infection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
Dual control of antitumor CD8 T cells through the programmed death-1/programmed death-ligand 1 pathway and immunosuppressive CD4 T cells: regulation and counterregulation.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
LFA-1 is critical for regulatory T cell homeostasis and function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
PD-1 signaling in primary T cells
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
PD-1 on dendritic cells impedes innate immunity against bacterial infection
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
T-cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
NFATc1 regulates PD-1 expression upon T cell activation.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
Interferon-sensitive response element (ISRE) is mainly responsible for IFN-alpha-induced upregulation of programmed death-1 (PD-1) in macrophages
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
CD8 T cell dysfunction during chronic viral infection.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
Cutting Edge: Programmed death (PD) ligand-1/PD-1 interaction is required for CD8+ T cell tolerance to tissue antigens
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
T-cell tolerance or function is determined by combinatorial costimulatory signals
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
Estrogen-mediated immunomodulation involves reduced activation of effector T cells, potentiation of Treg cells, and enhanced expression of the PD-1 costimulatory pathway
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
The when and wheres of CDC25 phosphatases
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-gamma-induced upregulation of B7-H1 (CD274).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
A critical role for the programmed death ligand 1 in fetomaternal tolerance
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
Antigen-independent memory CD8 T cells do not develop during chronic viral infection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
In vivo instruction of suppressor commitment in naive T cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
Regulation of T lymphocyte metabolism
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
T cell anergy and costimulation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
B7-H1 (programmed death-1 ligand) on dendritic cells is involved in the induction and maintenance of T cell anergy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
The dual-function CD150 receptor subfamily: the viral attraction
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
The CD28 signaling pathway regulates glucose metabolism
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
Expression and regulation of the PD-L1 immunoinhibitory molecule on microvascular endothelial cells
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
CD28, CTLA-4 and their ligands: who does what and to whom?
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
The small GTPase, Rap1, mediates CD31-induced integrin adhesion
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
Facilitation of beta selection and modification of positive selection in the thymus of PD-1-deficient mice
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
CTLA-4 and T cell activation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
Regulation of immune responses through inhibitory receptors
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
CD28 induces cell cycle progression by IL-2-independent down-regulation of p27kip1 expression in human peripheral T lymphocytes
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
A two-step, two-signal model for the primary activation of precursor helper T cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
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29 September 2017
Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-CD8-) thymocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
T-cell clonal anergy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
29 September 2017
Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
2 June 2018
Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
2 June 2018
Rap1A regulates generation of T regulatory cells via LFA-1-dependent and LFA-1-independent mechanisms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
2 June 2018
Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
2 June 2018
Regulation of cell signaling by the protein tyrosine phosphatases, CD45 and SHP-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
2 June 2018
TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
20 June 2018
Programmed Death-1 Blockade With Pembrolizumab in Patients With Classical Hodgkin Lymphoma After Brentuximab Vedotin Failure.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
27 November 2018
Combination checkpoint blockade--taking melanoma immunotherapy to the next level.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
27 November 2018
PD-1 deficiency results in the development of fatal myocarditis in MRL mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
27 November 2018
Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
27 November 2018
The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
27 November 2018
PD-L2 expression extends beyond dendritic cells/macrophages to B1 cells enriched for V(H)11/V(H)12 and phosphatidylcholine binding.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
27 November 2018
TGF-beta1 modulates Foxp3 expression and regulatory activity in distinct CD4+ T cell subsets.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
27 November 2018
Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
27 November 2018
Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-{gamma} and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
27 November 2018
Selective survival of naturally occurring human CD4+CD25+Foxp3+ regulatory T cells cultured with rapamycin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
27 November 2018
Conditional deletion of Shp2 tyrosine phosphatase in thymocytes suppresses both pre-TCR and TCR signals.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
27 November 2018
CD4+PD-1+ T cells acting as regulatory cells during the induction of anterior chamber-associated immune deviation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
27 November 2018
CD28 costimulation mediates transcription of SKP2 and CKS1, the substrate recognition components of SCFSkp2 ubiquitin ligase that leads p27kip1 to degradation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
27 November 2018
Cyclin-dependent kinases regulate the antiproliferative function of Smads
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
27 November 2018
Structural and functional analysis of the costimulatory receptor programmed death-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
27 November 2018
Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
27 November 2018
CD28 costimulation mediates T cell expansion via IL-2-independent and IL-2-dependent regulation of cell cycle progression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
27 November 2018
Targeting the B7/CD28:CTLA-4 costimulatory system in CNS autoimmune disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149523
retrieved
27 November 2018
DCs sensitized with mPD-L1-Ig fusion protein improve the effect of heart transplantation in mice by promoting the generation of T-reg cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/28018338
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/28018338
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
B7-H1-induced apoptosis as a mechanism of immune privilege of corneal allografts
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/28018338
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A Theory of Self-Nonself Discrimination: Paralysis and induction involve the recognition of one and two determinants on an antigen, respectively
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/28018338
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
CD18 is required for optimal development and function of CD4+CD25+ T regulatory cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/28018338
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Differential effects of costimulatory pathway modulation on corneal allograft survival
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/28018338
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/28018338
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Trophoblast CD274 (B7-H1) is differentially expressed across gestation: influence of oxygen concentration
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/28018338
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Overexpression of B7-H1 (PD-L1) significantly associates with tumor grade and postoperative prognosis in human urothelial cancers
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/28018338
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
PD-L1 is expressed by human renal tubular epithelial cells and suppresses T cell cytokine synthesis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/28018338
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.3389/FIMMU.2016.00550
0 references
PMC publication ID
5149523
0 references
PubMed publication ID
28018338
1 reference
stated in
PubMed
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