(Q28079188)

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7 March 2020

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8 February 2021

31 July 2022

Telomerase as a Cancer Target. Development of New Molecules (English)

2 references

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7 March 2020

1 reference

2 October 2019

1 reference

20 December 2019

1 reference

14 September 2020

1 reference

8 February 2021

3

1 reference

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Pablo Daniel Ghiringhelli

7 March 2020

4

1 reference

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7 March 2020

author name string

D L Mengual Gomez

1

1 reference

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7 March 2020

R G Armando

2

1 reference

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7 March 2020

D E Gomez

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7 March 2020

language of work or name

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1 January 2016

1 reference

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Current Topics in Medicinal Chemistry

7 March 2020

published in

12 references

3 April 2019

28 September 2019

2 October 2019

28 November 2019

19 December 2019

20 December 2019

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7 March 2020

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16

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7 March 2020

issue

22

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7 March 2020

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2432-2440

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Creative Commons Attribution-NonCommercial

7 March 2020

copyright license

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28 September 2019

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ScienceSource

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The RNA component of human telomerase

20 March 2017

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Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

20 March 2017

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Conservation of the human telomere sequence (TTAGGG)n among vertebrates

20 March 2017

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Computel: computation of mean telomere length from whole-genome next-generation sequencing data

29 September 2017

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Telomerase inhibition decreases alpha-fetoprotein expression and secretion by hepatocellular carcinoma cell lines: in vitro and in vivo study

29 September 2017

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Immunogenicity of GX301 cancer vaccine: Four (telomerase peptides) are better than one.

29 September 2017

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c-Myc quadruplex-forming sequence Pu-27 induces extensive damage in both telomeric and nontelomeric regions of DNA.

29 September 2017

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Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases.

29 September 2017

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Telomerase and the search for the end of cancer

29 September 2017

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29 September 2017

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Anti-cancer targeting telomerase inhibitors: β-rubromycin and oleic acid

29 September 2017

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29 September 2017

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29 September 2017

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Is telomerase a viable target in cancer?

29 September 2017

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Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins

29 September 2017

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Therapeutic cancer vaccines: are we there yet?

29 September 2017

1 reference

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Telomerase inhibition potentiates the effects of genotoxic agents in breast and colorectal cancer cells in a cell cycle-specific manner.

29 September 2017

1 reference

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"One Ring to Bind Them All"-Part II: Identification of Promising G-Quadruplex Ligands by Screening of Cyclophane-Type Macrocycles

29 September 2017

1 reference

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Structural identity of telomeric complexes

29 September 2017

1 reference

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POT1 deficiency alters telomere length and telomere-associated gene expression in human gastric cancer cells

29 September 2017

1 reference

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TPP1 is required for TERT recruitment, telomere elongation during nuclear reprogramming, and normal skin development in mice

29 September 2017

1 reference

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The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

G-quadruplex ligand SYUIQ-5 induces autophagy by telomere damage and TRF2 delocalization in cancer cells

29 September 2017

1 reference

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A phase I study of telomerase-specific replication competent oncolytic adenovirus (telomelysin) for various solid tumors

29 September 2017

1 reference

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CpG-island promoters drive transcription of human telomeres

29 September 2017

1 reference

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Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

The telomerase template antagonist GRN163L alters MDA-MB-231 breast cancer cell morphology, inhibits growth, and augments the effects of paclitaxel

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

siRNA inhibition of telomerase enhances the anti-cancer effect of doxorubicin in breast cancer cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Lipid-conjugated telomerase template antagonists sensitize resistant HER2-positive breast cancer cells to trastuzumab

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

3'-Azido-2',3'-dideoxynucleoside 5'-triphosphates inhibit telomerase activity in vitro, and the corresponding nucleosides cause telomere shortening in human HL60 cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Tankyrase function at telomeres, spindle poles, and beyond.

29 September 2017

1 reference

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Telomerase and its potential for therapeutic intervention

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA.

29 September 2017

1 reference

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Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2.

29 September 2017

1 reference

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Telomerase immunity from bench to bedside: round one.

29 September 2017

1 reference

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Telomerase inhibition in cancer therapeutics: molecular-based approaches

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Biopharmaceutical characterization of the telomerase inhibitor BRACO19.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Enhanced antitumor efficacy of telomerase-selective oncolytic adenoviral agent OBP-401 with docetaxel: preclinical evaluation of chemovirotherapy.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Ascididemin and meridine stabilise G-quadruplexes and inhibit telomerase in vitro.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Telomerase Inhibition Using Azidothymidine in the HT-29 Colon Cancer Cell Line

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Synergy between 3'-azido-3'-deoxythymidine and paclitaxel in human pharynx FaDu cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Specific interactions of distamycin with G-quadruplex DNA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

The cationic porphyrin TMPyP4 down-regulates c-MYC and human telomerase reverse transcriptase expression and inhibits tumor growth in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Inhibition of telomerase activity by a distamycin derivative: effects on cell proliferation and induction of apoptosis in human cancer cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Alternative lengthening of telomeres in human cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Telomerase: a therapeutic target for the third millennium?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Associations among telomerase activity, p53 protein overexpression, and genetic instability in lung cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Reduction of telomeric signals in murine melanoma and human breast cancer cell lines treated with 3'-azido-2'-3'-dideoxythymidine.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Reverse transcriptase inhibitors suppress telomerase function and induce senescence-like processes in cultured mouse fibroblasts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Glucose restriction decreases telomerase activity and enhances its inhibitor response on breast cancer cells: possible extra-telomerase role of BIBR 1532.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

The parallel G-quadruplex structure of vertebrate telomeric repeat sequences is not the preferred folding topology under physiological conditions.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

A multicenter randomized phase IIb efficacy study of Vx-001, a peptide-based cancer vaccine as maintenance treatment in advanced non-small-cell lung cancer: treatment rationale and protocol dynamics

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Synthesis and binding studies of novel di-substituted phenanthroline compounds with genomic promoter and human telomeric DNA G-quadruplexes

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Clinical outcome of patients with various advanced cancer types vaccinated with an optimized cryptic human telomerase reverse transcriptase (TERT) peptide: results of an expanded phase II study.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Immunological responses in cancer patients after vaccination with the therapeutic telomerase-specific vaccine Vx-001.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Intracellular dynamics of the Hsp90 co-chaperone p23 is dictated by Hsp90.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Inhibition of human telomerase by diphosphates of acyclic nucleoside phosphonates

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Inhibition of Vertebrate Telomerases by the Triphosphate Derivatives of Some Biologically Active Nucleosides

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Dictyodendrins A-E, the first telomerase-inhibitory marine natural products from the sponge Dictyodendrilla verongiformis

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

A novel topoisomerase II poison GL331 preferentially induces DNA cleavage at (C/G)T sites and can cause telomere DNA damage

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Inhibition of human telomerase by 7-deaza-2'-deoxyguanosine nucleoside triphosphate analogs: potent inhibition by 6-thio-7-deaza-2'-deoxyguanosine 5'-triphosphate

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4997958

Diazaphilonic acid, a new azaphilone with telomerase inhibitory activity

27 November 2018

1 reference

12 December 2020

Inhibition of telomerase activity by fungus metabolites, CRM646-A and thielavin B

1 reference

12 December 2020

Synthesis of distamycin A polyamides targeting G-quadruplex DNA

1 reference

12 December 2020

Inhibition of telomerase activity and cell proliferation by a reverse transcriptase inhibitor in gynaecological cancer cell lines

1 reference

12 December 2020

Irreversible telomere shortening by 3'-azido-2',3'-dideoxythymidine (AZT) treatment

1 reference

12 December 2020

Preferential incorporation of 3'-azido-2',3'-dideoxythymidine into telomeric DNA and Z-DNA-containing regions of Chinese hamster ovary cells

1 reference

12 December 2020

Inhibition of human telomerase by rubromycins: implication of spiroketal system of the compounds as an active moiety

1 reference

12 December 2020

Telomerase inhibition by 3'-azido-2', 3'-dideoxynucleoside 5'-triphosphates and telomere shortening in human cultured cells by the corresponding nucleosides

1 reference

12 December 2020

Interaction of deoxyguanosine nucleotide analogs with human telomerase

1 reference

12 December 2020

Human telomerase inhibition by 7-deaza-2'-deoxypurine nucleoside triphosphates

1 reference

12 December 2020

Preferential incorporation of 3'-azido-2',3'-dideoxythymidine (azt) in telomeric sequences of cho cells

1 reference

12 December 2020

Solid phase versus solution phase synthesis of heterocyclic macrocycles

1 reference

12 December 2020

Maximum tolerable doses of intravenous zidovudine in combination with 5-fluorouracil and leucovorin in metastatic colorectal cancer patients. Clinical evidence of significant antitumor activity and enhancement of zidovudine-induced DNA single strand

1 reference

12 December 2020

10.2174/1568026616666160212122425

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26873194%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26873194%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

PubMed publication ID

26873194

2 references