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Review on molecular and chemopreventive potential of nimbolide in cancer
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PubMed
review article
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stated in
Europe PubMed Central
title
Review on molecular and chemopreventive potential of nimbolide in cancer
(English)
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stated in
PubMed
author name string
Perumal Elumalai
series ordinal
1
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stated in
Crossref
Jagadeesan Arunakaran
series ordinal
2
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stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
December 2014
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stated in
PubMed
published in
Genomics & Informatics
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stated in
PubMed
volume
12
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stated in
PubMed
issue
4
1 reference
stated in
PubMed
page(s)
156-64
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stated in
PubMed
copyright license
Creative Commons Attribution-NonCommercial 3.0 Unported
start time
1 January 2014
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stated in
April 2022 Public Data File from Crossref
copyright status
copyrighted
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cites work
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20 March 2017
Emerging roles of caspase-3 in apoptosis
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Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion
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Cell death: critical control points
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The protein kinase B/Akt signalling pathway in human malignancy
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Cancer cell cycles
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7 April 2017
Nimbolide inhibits invasion and migration, and down-regulates uPAR chemokine gene expression, in two breast cancer cell lines
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Expressional analysis of p16 and cytokeratin19 protein in the genesis of oral squamous cell carcinoma patients
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29 September 2017
Nimbolide inhibits IGF-I-mediated PI3K/Akt and MAPK signalling in human breast cancer cell lines (MCF-7 and MDA-MB-231).
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29 September 2017
Chemopreventive and therapeutic effects of nimbolide in cancer: the underlying mechanisms
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PubMed Central
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29 September 2017
Direct inhibition of retinoblastoma phosphorylation by nimbolide causes cell-cycle arrest and suppresses glioblastoma growth.
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29 September 2017
Anti-proliferative and apoptosis inducing effect of nimbolide by altering molecules involved in apoptosis and IGF signalling via PI3K/Akt in prostate cancer (PC-3) cell line
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29 September 2017
Nimbolide, a limonoid triterpene, inhibits growth of human colorectal cancer xenografts by suppressing the proinflammatory microenvironment
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29 September 2017
Casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer cells
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Phosphorylation of AKT pathway proteins is not predictive of benefit of taxane therapy in early breast cancer
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29 September 2017
The urokinase plasminogen activator system in breast cancer invasion and metastasis
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29 September 2017
Nimbolide, a neem limonoid abrogates canonical NF-κB and Wnt signaling to induce caspase-dependent apoptosis in human hepatocarcinoma (HepG2) cells
1 reference
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29 September 2017
PTEN-mediated AKT activation contributes to the reduced apoptosis among Indian oral squamous cell carcinoma patients.
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29 September 2017
Anticancer biology of Azadirachta indica L (neem): a mini review
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29 September 2017
Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA-binding activity of NF-κB in colon cancer cells
1 reference
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29 September 2017
Induction of apoptosis and inhibition of PI3K/Akt pathway in PC-3 and LNCaP prostate cancer cells by ethanolic neem leaf extract
1 reference
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retrieved
29 September 2017
Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax.
1 reference
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retrieved
29 September 2017
Modification of cysteine 179 of IkappaBalpha kinase by nimbolide leads to down-regulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents
1 reference
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PubMed Central
reference URL
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29 September 2017
The neem limonoids azadirachtin and nimbolide induce cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells
1 reference
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reference URL
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29 September 2017
Regulation of breast cancer metastasis by IGF signaling
1 reference
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29 September 2017
Nimbolide a limonoid from Azadirachta indica inhibits proliferation and induces apoptosis of human choriocarcinoma (BeWo) cells
1 reference
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29 September 2017
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29 September 2017
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29 September 2017
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29 September 2017
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29 September 2017
Antiproliferative effect on human cancer cell lines after treatment with nimbolide extracted from an edible part of the neem tree (Azadirachta indica).
1 reference
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reference URL
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29 September 2017
Synthesis and biological activity of amide derivatives of nimbolide
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IkappaBepsilon provides negative feedback to control NF-kappaB oscillations, signaling dynamics, and inflammatory gene expression.
1 reference
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29 September 2017
Anticancer effects of ethanolic neem leaf extract on prostate cancer cell line (PC-3).
1 reference
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PubMed Central
reference URL
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Promoting apoptosis as a strategy for cancer drug discovery
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29 September 2017
The NF-kappaB pathway
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Insulin-like growth factors and neoplasia.
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PubMed Central
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reference URL
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29 September 2017
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1 reference
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330249
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29 September 2017
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reference URL
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2 June 2018
Nimbolide, a constituent of Azadirachta indica, inhibits Plasmodium falciparum in culture.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330249
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2 June 2018
Spectroscopic and biological investigation of nimbolide and 28-deoxonimbolide from Azadirachta indica
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PubMed Central
reference URL
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Cancer stem cells: recent developments and future prospects
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330249
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27 November 2018
Induction of apoptosis in human breast cancer cells by nimbolide through extrinsic and intrinsic pathway
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330249
retrieved
27 November 2018
The neem limonoids azadirachtin and nimbolide inhibit cell proliferation and induce apoptosis in an animal model of oral oncogenesis.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330249
retrieved
27 November 2018
The neem limonoids azadirachtin and nimbolide inhibit hamster cheek pouch carcinogenesis by modulating xenobiotic-metabolizing enzymes, DNA damage, antioxidants, invasion and angiogenesis.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330249
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27 November 2018
Inhibition of colon cancer (HT-29) cell proliferation by a triterpenoid isolated from Azadirachta indica is accompanied by cell cycle arrest and up-regulation of p21.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330249
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27 November 2018
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330249
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27 November 2018
Quinone reductase inducers in Azadirachta indica A. Juss flowers, and their mechanisms of action.
1 reference
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330249
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27 November 2018
Akt is frequently activated in HER2/neu-positive breast cancers and associated with poor prognosis among hormone-treated patients
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PubMed Central
reference URL
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27 November 2018
Ethanolic neem leaf extract protects against N-methyl -N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in Wistar rats
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330249
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27 November 2018
Semi-synthetic modification of nimbolide to 6-homodesacetylnimbin and 6-desacetylnimbin and their cytotoxic studies
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25705153
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
PTEN promoter is methylated in a proportion of invasive breast cancers
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25705153
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.5808/GI.2014.12.4.156
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/rj3fqjdh4nanxdhclb4hpu2roe
retrieved
30 July 2022
based on heuristic
mapped directly with Wikidata item
Fatcat ID
release_rj3fqjdh4nanxdhclb4hpu2roe
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/rj3fqjdh4nanxdhclb4hpu2roe
retrieved
30 July 2022
based on heuristic
mapped directly with Wikidata item
PMCID
4330249
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/rj3fqjdh4nanxdhclb4hpu2roe
retrieved
30 July 2022
based on heuristic
mapped directly with Wikidata item
PubMed ID
25705153
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/rj3fqjdh4nanxdhclb4hpu2roe
retrieved
30 July 2022
based on heuristic
mapped directly with Wikidata item
ResearchGate publication ID
271722728
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