(Q37334032)

19 August 2017

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title

Regulation of breast cancer metastasis by IGF signaling (English)

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19 August 2017

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Deepali Sachdev

1

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19 August 2017

publication date

22 November 2008

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Journal of Mammary Gland Biology and Neoplasia

19 August 2017

published in

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19 August 2017

volume

13

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19 August 2017

issue

4

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19 August 2017

page(s)

431-441

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https://scigraph.springernature.com/pub.10.1007/s10911-008-9105-5

19 August 2017

exact match

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cites work

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12 December 2020

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Low activation of Insulin-like Growth Factor 1-Receptor (IGF1R) is associated with local recurrence in early breast carcinoma

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Involvement of insulin receptor substrate 2 in mammary tumor metastasis

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Motility response to insulin-like growth factor-I (IGF-I) in MCF-7 cells is associated with IRS-2 activation and integrin expression

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Hypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors

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Phase I dose escalation study of the anti insulin-like growth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors

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12 December 2020

Potential Applications for Circulating Tumor Cells Expressing the Insulin-Like Growth Factor-I Receptor

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12 December 2020

Loss of the metastatic phenotype in murine carcinoma cells expressing an antisense RNA to the insulin-like growth factor receptor

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12 December 2020

Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer

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12 December 2020

Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells.

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12 December 2020

Type 1 IGF receptor in human breast diseases

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12 December 2020

Novel human monoclonal antibodies to insulin-like growth factor (IGF)-II that potently inhibit the IGF receptor type I signal transduction function

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12 December 2020

MDA-MB-435 cells are derived from M14 melanoma cells--a loss for breast cancer, but a boon for melanoma research

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12 December 2020

Neoadjuvant Chemotherapy of Locally Advanced Breast Cancer: Predicting Response with in Vivo1H MR Spectroscopy—A Pilot Study at 4 T

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12 December 2020

In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417.

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12 December 2020

RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251.

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12 December 2020

Effectiveness of insulin-like growth factor I receptor antisense strategy against Ewing's sarcoma cells

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12 December 2020

Dissemination and growth of cancer cells in metastatic sites

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12 December 2020

Targeting the IGF-1 receptor: from rags to riches

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12 December 2020

The insulin-like growth factor-I receptor. Structure, ligand-binding mechanism and signal transduction.

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12 December 2020

The insulin-like growth factor-1 elevates urokinase-type plasminogen activator-1 in human breast cancer cells: a new avenue for breast cancer therapy.

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12 December 2020

Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice

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12 December 2020

A dominant negative type I insulin-like growth factor receptor inhibits metastasis of human cancer cells.

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12 December 2020

Up-regulation of urokinase-type plasminogen activator by insulin-like growth factor-I depends upon phosphatidylinositol-3 kinase and mitogen-activated protein kinase kinase.

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12 December 2020

Deregulation of both imprinted and expressed alleles of the insulin-like growth factor 2 gene during beta-cell tumorigenesis

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12 December 2020

Progesterone receptor-B regulation of insulin-like growth factor-stimulated cell migration in breast cancer cells via insulin receptor substrate-2.

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12 December 2020

The insulin-like growth factor system and cancer

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12 December 2020

Vascular endothelial growth factor C expression and lymph node metastasis are regulated by the type I insulin-like growth factor receptor.

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12 December 2020

Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity

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12 December 2020

Mouse mutants lacking the type 2 IGF receptor (IGF2R) are rescued from perinatal lethality in Igf2 and Igf1r null backgrounds

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12 December 2020

Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer

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12 December 2020

RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix

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12 December 2020

Magnetic resonance spectroscopy monitoring of mitogen-activated protein kinase signaling inhibition

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12 December 2020

A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo.

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12 December 2020

Insulin and hybrid insulin/IGF receptors are major regulators of breast cancer cells.

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12 December 2020

Cell signalling: growth factors and tyrosine kinase receptors

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12 December 2020

Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2

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12 December 2020

Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant

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12 December 2020

Inhibition of insulin-like growth factor-I receptor (IGF-IR) signaling and tumor cell growth by a fully human neutralizing anti-IGF-IR antibody

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12 December 2020

A bone-seeking clone exhibits different biological properties from the MDA-MB-231 parental human breast cancer cells and a brain-seeking clone in vivo and in vitro

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12 December 2020

A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis

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12 December 2020

Cancer metastasis: building a framework

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12 December 2020

Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 insulin-like growth factor receptor

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12 December 2020

Interaction of the .alpha..beta. dimers of the insulin-like growth factor I receptor is required for receptor autophosphorylation

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12 December 2020

Targeting HIF-1 for cancer therapy

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12 December 2020

Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis

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12 December 2020

Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: lessons from the first clinical trials

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12 December 2020

The prognostic value of insulin-like growth factor-I in breast cancer patients. Results of a follow-up study on 126 patients

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12 December 2020

Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells

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12 December 2020

Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871.

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12 December 2020

Insulin-like growth factor-I receptor expression regulates neuroblastoma metastasis to bone.

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12 December 2020

MDA435/LCC6 and MDA435/LCC6MDR1: ascites models of human breast cancer.

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12 December 2020

Focus on lymphangiogenesis in tumor metastasis.

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12 December 2020

Androgen receptor (AR) expression in AR-negative prostate cancer cells results in differential effects of DHT and IGF-I on proliferation and AR activity between localized and metastatic tumors

1 reference

12 December 2020

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity

1 reference

12 December 2020

Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis

1 reference

12 December 2020

Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved

1 reference

12 December 2020

A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo

1 reference

12 December 2020

Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo

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12 December 2020

Biochemical evidence that the type II insulin-like growth factor receptor is identical to the cation-independent mannose 6-phosphate receptor

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12 December 2020

A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts

1 reference

12 December 2020

Regulation of breast cancer cell motility by insulin receptor substrate-2 (IRS-2) in metastatic variants of human breast cancer cell lines

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12 December 2020

Cellular actions of the insulin-like growth factor binding proteins

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12 December 2020

A single receptor binds both insulin-like growth factor II and mannose-6-phosphate

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12 December 2020

The discovery of receptor tyrosine kinases: targets for cancer therapy

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12 December 2020

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

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12 December 2020

Impact of insulin-like growth factor receptor-I function on angiogenesis, growth, and metastasis of colon cancer

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12 December 2020

Insulin receptor substrates mediate distinct biological responses to insulin-like growth factor receptor activation in breast cancer cells.

1 reference

12 December 2020

Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling

1 reference

12 December 2020

Insulin-like growth factor-1 receptor in uveal melanoma: a predictor for metastatic disease and a potential therapeutic target

1 reference

12 December 2020

Insulinlike growth factor-I-mediated migration and invasion of human colon carcinoma cells requires activation of c-Met and urokinase plasminogen activator receptor

1 reference

12 December 2020

Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways.

1 reference

12 December 2020

An anti-insulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation

1 reference

12 December 2020

Insulin-like growth factor II receptor as a multifunctional binding protein

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12 December 2020

Insulin-like growth factor binding protein-1 (IGFBP-1) inhibits breast cancer cell motility.

1 reference

12 December 2020

Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway

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12 December 2020

Enhanced invasion and liver colonization by lung carcinoma cells overexpressing the type 1 insulin-like growth factor receptor

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12 December 2020

Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis

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12 December 2020

Molecular determinants of angiogenesis in cancer metastasis.

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12 December 2020

A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer.

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12 December 2020

Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration

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12 December 2020

Anti-apoptotic signaling of the IGF-I receptor in fibroblasts following loss of matrix adhesion

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12 December 2020

Insulin Receptor Substrate-1 is the Predominant Signaling Molecule Activated by Insulin-like Growth Factor-I, Insulin, and Interleukin-4 in Estrogen Receptor-positive Human Breast Cancer Cells

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12 December 2020

Combined in vivo effect of A12, a type 1 insulin-like growth factor receptor antibody, and docetaxel against prostate cancer tumors.

1 reference

12 December 2020

Targeting the type 1 insulin-like growth factor receptor as anti-cancer treatment

1 reference

12 December 2020

Divergent roles for IRS-1 and IRS-2 in breast cancer metastasis

1 reference

12 December 2020

Inhibition of growth and metastases of MDA-MB-435 human estrogen-independent breast cancers by an antagonist of growth hormone-releasing hormone

1 reference

12 December 2020

Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling

1 reference

12 December 2020

Disruption of ligand binding to the insulin-like growth factor II/mannose 6-phosphate receptor by cancer-associated missense mutations.

1 reference

12 December 2020

The implications of angiogenesis for the biology and therapy of cancer metastasis

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12 December 2020

Insulin-like growth factors and neoplasia

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12 December 2020

1 reference

12 December 2020

Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer

1 reference

12 December 2020

Growth inhibition of human prostate cancer cells in human adult bone implanted into nonobese diabetic/severe combined immunodeficient mice by a ligand-specific antibody to human insulin-like growth factors

1 reference

12 December 2020

Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration

1 reference

12 December 2020

Reexpression of the type 1 insulin-like growth factor receptor inhibits the malignant phenotype of simian virus 40 T antigen immortalized human prostate epithelial cells

1 reference

12 December 2020

Signalling through IGF-I and insulin receptors: where is the specificity?

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12 December 2020

Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis

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12 December 2020

IMC-A12, a human IgG1 monoclonal antibody to the insulin-like growth factor I receptor

1 reference

12 December 2020

10.1007/S10911-008-9105-5

Identifiers

DOI

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19 August 2017

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