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The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis
scientific journal article
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scholarly article
1 reference
stated in
PubMed
PubMed ID
27013495
retrieved
3 January 2017
title
The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis
(English)
1 reference
stated in
PubMed
PubMed ID
27013495
retrieved
3 January 2017
main subject
apoptotic process
0 references
Ubiquitin specific peptidase 27, X chromosome
1 reference
stated in
GOA release 2020-03-11
BCL2-like 11 (apoptosis facilitator)
1 reference
stated in
GOA release 2020-03-11
author
Arnim Weber
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
5341510
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27013495%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
Melanie Heinlein
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
5341510
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27013495%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
Jörn Dengjel
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMCID
5341510
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27013495%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
Prafull Kumar Singh
series ordinal
5
1 reference
stated in
Europe PubMed Central
PMCID
5341510
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27013495%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
Georg Häcker
series ordinal
6
1 reference
stated in
Europe PubMed Central
PMCID
5341510
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27013495%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
author name string
Claudia Alber
series ordinal
4
2 references
stated in
PubMed
PubMed ID
27013495
retrieved
3 January 2017
stated in
Europe PubMed Central
PMCID
5341510
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27013495%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
language of work or name
English
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based on heuristic
inferred from title
publication date
1 May 2016
1 reference
stated in
PubMed
PubMed ID
27013495
retrieved
3 January 2017
published in
EMBO Reports
2 references
stated in
PubMed
PubMed ID
27013495
retrieved
3 January 2017
stated in
Europe PubMed Central
PMCID
5341510
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27013495%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
volume
17
2 references
stated in
PubMed
PubMed ID
27013495
retrieved
3 January 2017
stated in
Europe PubMed Central
PMCID
5341510
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27013495%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
page(s)
724-738
1 reference
stated in
Europe PubMed Central
PMCID
5341510
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27013495%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
issue
5
2 references
stated in
PubMed
PubMed ID
27013495
retrieved
3 January 2017
stated in
Europe PubMed Central
PMCID
5341510
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27013495%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
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Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics
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BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations
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Antibody Array Revealed PRL-3 Affects Protein Phosphorylation and Cytokine Secretion
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ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL
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BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax
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29 September 2017
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
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29 September 2017
Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells
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29 September 2017
Oncogenic B-RafV600E inhibits apoptosis and promotes ERK-dependent inactivation of Bad and Bim.
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29 September 2017
Multisite phosphorylation regulates Bim stability and apoptotic activity
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29 September 2017
Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas
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29 September 2017
Cdc20: a WD40 activator for a cell cycle degradation machine
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29 September 2017
BimS-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins
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29 September 2017
Frequent loss of expression of the pro-apoptotic protein Bim in renal cell carcinoma: evidence for contribution to apoptosis resistance.
1 reference
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29 September 2017
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas
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29 September 2017
Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5341510
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29 September 2017
Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy.
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29 September 2017
Bim is a suppressor of Myc-induced mouse B cell leukemia
1 reference
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PubMed Central
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29 September 2017
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5341510
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29 September 2017
Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5341510
retrieved
29 September 2017
The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5341510
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29 September 2017
Deubiquitinating enzymes regulate Hes1 stability and neuronal differentiation
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PubMed Central
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2 June 2018
BimEL is phosphorylated at mitosis by Aurora A and targeted for degradation by βTrCP1.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5341510
retrieved
2 June 2018
Bim expression is reduced in human cutaneous melanomas
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5341510
retrieved
27 November 2018
FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5341510
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27 November 2018
Identification of a functional nuclear localization signal within the human USP22 protein
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27013495
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.15252/EMBR.201541392
1 reference
stated in
Europe PubMed Central
PMCID
5341510
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27013495%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
PMCID
5341510
1 reference
stated in
Europe PubMed Central
PMCID
5341510
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27013495%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
PubMed ID
27013495
2 references
stated in
PubMed
PubMed ID
27013495
retrieved
3 January 2017
stated in
Europe PubMed Central
PMCID
5341510
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27013495%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
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