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Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1
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scholarly article
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PubMed
PubMed ID
19734539
retrieved
4 January 2017
title
Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1
(English)
1 reference
stated in
PubMed
PubMed ID
19734539
retrieved
4 January 2017
main subject
regulation of DNA helicase activity
1 reference
stated in
Gene Ontology release 2020-05-02
Gene Ontology ID
GO:1905774
telomeric D-loop binding
1 reference
stated in
Gene Ontology release 2020-05-02
Gene Ontology ID
GO:0061821
8-hydroxy-2'-deoxyguanosine DNA binding
1 reference
stated in
Gene Ontology release 2020-05-02
Gene Ontology ID
GO:1905773
negative regulation of DNA helicase activity
1 reference
stated in
Gene Ontology release 2020-05-02
Gene Ontology ID
GO:1905775
positive regulation of DNA helicase activity
1 reference
stated in
Gene Ontology release 2020-05-02
Gene Ontology ID
GO:1905776
Protection of telomeres 1
1 reference
stated in
GOA release 2020-03-11
Werner syndrome RecQ like helicase
1 reference
stated in
GOA release 2020-03-11
BLM RecQ like helicase
1 reference
stated in
GOA release 2020-03-11
telomeric G-quadruplex DNA binding
1 reference
stated in
GOA release 2020-03-11
Bloom syndrome
1 reference
based on heuristic
inferred from title
author
Vilhelm A. Bohr
series ordinal
5
object named as
Vilhelm A. Bohr
1 reference
stated in
PubMed
PubMed ID
19734539
retrieved
4 January 2017
author name string
Avik Ghosh
series ordinal
1
1 reference
stated in
PubMed
PubMed ID
19734539
retrieved
4 January 2017
Marie L. Rossi
series ordinal
2
1 reference
stated in
PubMed
PubMed ID
19734539
retrieved
4 January 2017
Jason Aulds
series ordinal
3
1 reference
stated in
PubMed
PubMed ID
19734539
retrieved
4 January 2017
Deborah Croteau
series ordinal
4
1 reference
stated in
PubMed
PubMed ID
19734539
retrieved
4 January 2017
language of work or name
English
0 references
publication date
6 November 2009
1 reference
stated in
PubMed
PubMed ID
19734539
retrieved
4 January 2017
published in
Journal of Biological Chemistry
1 reference
stated in
PubMed
PubMed ID
19734539
retrieved
4 January 2017
volume
284
1 reference
stated in
PubMed
PubMed ID
19734539
retrieved
4 January 2017
issue
45
1 reference
stated in
PubMed
PubMed ID
19734539
retrieved
4 January 2017
page(s)
31074–31084
1 reference
stated in
PubMed
PubMed ID
19734539
retrieved
4 January 2017
describes a project that uses
ImageQuant
1 reference
stated in
Europe PubMed Central
retrieved
11 June 2022
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2781507/fullTextXML
based on heuristic
inferred from PubMed Central ID database lookup
cites work
Mammalian telomeres end in a large duplex loop
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
20 March 2017
Oligomeric ring structure of the Bloom's syndrome helicase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
20 March 2017
Crystal structure of parallel quadruplexes from human telomeric DNA
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
20 March 2017
Instability and decay of the primary structure of DNA
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
20 March 2017
Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
20 March 2017
The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
20 March 2017
Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
20 March 2017
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
20 March 2017
Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
20 March 2017
The sacrificial role of easily oxidizable sites in the protection of DNA from damage.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
20 March 2017
Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
20 March 2017
DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
20 March 2017
X-ray structure of a DNA decamer containing 7,8-dihydro-8-oxoguanine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
20 March 2017
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
20 March 2017
TRF2 Protects Human Telomeres from End-to-End Fusions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
20 March 2017
Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
20 March 2017
Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
20 March 2017
Essential role of limiting telomeres in the pathogenesis of Werner syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
20 March 2017
Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
20 March 2017
Origin of Concatemeric T7DNA
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
20 March 2017
Telomeres shorten during ageing of human fibroblasts
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
7 April 2017
Regulation of telomerase by telomeric proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
7 April 2017
Oxidative stress shortens telomeres
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
7 April 2017
Switching and signaling at the telomere
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
7 April 2017
RecQ helicases: caretakers of the genome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
7 April 2017
Protection of mammalian telomeres
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
7 April 2017
Positional cloning of the Werner's syndrome gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
7 April 2017
The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
7 April 2017
Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
29 September 2017
Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
29 September 2017
Association of human DNA helicase RecQ5beta with RNA polymerase II and its possible role in transcription.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
29 September 2017
Telomere ResQue and preservation--roles for the Werner syndrome protein and other RecQ helicases.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
29 September 2017
Guanines are a quartet's best friend: impact of base substitutions on the kinetics and stability of tetramolecular quadruplexes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
29 September 2017
The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
29 September 2017
Site-specific probing of oxidative reactivity and telomerase function using 7,8-dihydro-8-oxoguanine in telomeric DNA.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
29 September 2017
Alternative lengthening of telomeres in mammalian cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
29 September 2017
Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
29 September 2017
Selective blockage of the 3'-->5' exonuclease activity of WRN protein by certain oxidative modifications and bulky lesions in DNA.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
29 September 2017
The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
29 September 2017
TRF1 binds a bipartite telomeric site with extreme spatial flexibility
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
29 September 2017
Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
29 September 2017
Bloom's syndrome protein, BLM, colocalizes with replication protein A in meiotic prophase nuclei of mammalian spermatocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
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29 September 2017
Mutagenesis by 8-oxoguanine: an enemy within
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
29 September 2017
Sequence-specific DNA cleavage by Fe2+-mediated fenton reactions has possible biological implications
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
2 June 2018
Telomeres, telomerase and cancer
2 references
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781507
retrieved
2 June 2018
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M109.027532
retrieved
21 January 2018
S-Adenosyl Methionine Prevents Promiscuous DNA Cleavage by the EcoP1I type III Restriction Enzyme
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M109.027532
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21 January 2018
Sugar and Disease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M109.027532
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21 January 2018
Site-specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19734539
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Sequential self-assembly of a DNA hexagon as a template for the organization of gold nanoparticles
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19734539
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Site-specific oxidation at GG and GGG sequences in double-stranded DNA by benzoyl peroxide as a tumor promoter
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19734539
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Reactive oxygen species in human health and disease
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19734539
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Selective interactions of cationic porphyrins with G-quadruplex structures
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19734539
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1074/JBC.M109.027532
0 references
PMCID
2781507
0 references
PubMed ID
19734539
1 reference
stated in
PubMed
PubMed ID
19734539
retrieved
4 January 2017
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