(Q6591532)

Winged helix DNA-binding domain superfamily

1 reference

Ribonuclease H superfamily

1 reference

Ribonuclease H-like superfamily

1 reference

P-loop containing nucleoside triphosphate hydrolase

1 reference

Winged helix-like DNA-binding domain superfamily

1 reference

HRDC-like superfamily

1 reference

Helicase superfamily 1/2, ATP-binding domain, protein family

1 reference

ATP-dependent DNA helicase RecQ, zinc-binding domain, protein family

1 reference

Helicase Helix-turn-helix domain, protein family

1 reference

Helicase, C-terminal domain, protein family

1 reference

DEAD/DEAH box helicase

1 reference

3'-5' exonuclease domain, protein family

1 reference

HRDC domain, protein family

1 reference

RQC domain, protein family

1 reference

WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing

1 reference

16 January 2019

1 reference

16 January 2019

manganese ion binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

protein homodimerization activity

1 reference

9 May 2019

Ku complex interacts with and stimulates the Werner protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs

DNA helicase activity

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

27 references

9 May 2019

Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Promyelocytic leukemia protein interacts with werner syndrome helicase and regulates double-strand break repair in γ-irradiation-induced DNA damage responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Ku complex interacts with and stimulates the Werner protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Werner syndrome helicase (WRN), nuclear DNA helicase II (NDH II) and histone gammaH2AX are localized to the centrosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

WRN interacts physically and functionally with the recombination mediator protein RAD52

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Functional and physical interaction between WRN helicase and human replication protein A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

p53 Modulates the exonuclease activity of Werner syndrome protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

p53 modulates RPA-dependent and RPA-independent WRN helicase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Stimulation of flap endonuclease-1 by the Bloom's syndrome protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Physical and functional interaction of the Werner syndrome protein with poly‐ADP ribosyl transferase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

3'-5' exonuclease activity

IPI

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Ku complex interacts with and stimulates the Werner protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Characterization of the human and mouse WRN 3'-->5' exonuclease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

3 references

9 May 2019

Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

3'-5' DNA helicase activity

1 reference

9 May 2019

Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing

magnesium ion binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

3 references

9 May 2019

The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

3'-flap-structured DNA binding

1 reference

9 May 2019

The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

four-way junction DNA binding

1 reference

9 May 2019

Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

forked DNA-dependent helicase activity

1 reference

9 May 2019

Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

telomeric G-quadruplex DNA binding

1 reference

9 May 2019

Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

8-hydroxy-2'-deoxyguanosine DNA binding

IC

1 reference

9 May 2019

Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

protein-containing complex binding

1 reference

9 May 2019

Ku complex interacts with and stimulates the Werner protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

4 references

1 January 2018

Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 January 2018

The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 January 2018

Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

3 references

1 January 2018

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 January 2018

Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

8 April 2019

The Werner syndrome protein is a DNA helicase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

3'-5' exonuclease activity

7 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 January 2018

Ku complex interacts with and stimulates the Werner protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 January 2018

WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 January 2018

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 January 2018

Characterization of the human and mouse WRN 3'-->5' exonuclease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

four-way junction helicase activity

3 references

9 May 2019

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

MutLalpha complex binding

1 reference

9 May 2019

Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events

telomeric D-loop binding

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 January 2018

Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

8-hydroxy-2'-deoxyguanosine DNA binding

1 reference

9 May 2019

Werner syndrome helicase (WRN), nuclear DNA helicase II (NDH II) and histone gammaH2AX are localized to the centrosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

intracellular anatomical structure

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14191&geneProductId=UniProtKB:Q14191

8 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14191&geneProductId=UniProtKB:Q14191

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14191&geneProductId=UniProtKB:Q14191

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14191&geneProductId=UniProtKB:Q14191

5 June 2018

Werner syndrome helicase (WRN), nuclear DNA helicase II (NDH II) and histone gammaH2AX are localized to the centrosome

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14191&geneProductId=UniProtKB:Q14191

5 June 2018

Promyelocytic leukemia protein interacts with werner syndrome helicase and regulates double-strand break repair in γ-irradiation-induced DNA damage responses

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14191&geneProductId=UniProtKB:Q14191

5 June 2018

Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14191&geneProductId=UniProtKB:Q14191

5 June 2018

Diverged nuclear localization of Werner helicase in human and mouse cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14191&geneProductId=UniProtKB:Q14191

5 June 2018

WRN translocation from nucleolus to nucleoplasm is regulated by SIRT1 and required for DNA repair and the development of chemoresistance

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14191&geneProductId=UniProtKB:Q14191

9 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Nucleolar localization of the Werner syndrome protein in human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Promyelocytic leukemia protein interacts with werner syndrome helicase and regulates double-strand break repair in γ-irradiation-induced DNA damage responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Werner syndrome helicase (WRN), nuclear DNA helicase II (NDH II) and histone gammaH2AX are localized to the centrosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Diverged nuclear localization of Werner helicase in human and mouse cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

WRN translocation from nucleolus to nucleoplasm is regulated by SIRT1 and required for DNA repair and the development of chemoresistance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 reference

5 June 2018

Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14191&geneProductId=UniProtKB:Q14191

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 January 2018

The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 January 2018

The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

3 references

9 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Promyelocytic leukemia protein interacts with werner syndrome helicase and regulates double-strand break repair in γ-irradiation-induced DNA damage responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Werner syndrome helicase (WRN), nuclear DNA helicase II (NDH II) and histone gammaH2AX are localized to the centrosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Diverged nuclear localization of Werner helicase in human and mouse cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

WRN translocation from nucleolus to nucleoplasm is regulated by SIRT1 and required for DNA repair and the development of chemoresistance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

DNA replication factor A complex

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14191&geneProductId=UniProtKB:Q14191

site of double-strand break

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

regulation of apoptotic process

biological process

1 reference

9 May 2019

Effect of age and apoptosis on the mouse homologue of the huWRN gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

positive regulation of hydrolase activity

IGI

1 reference

9 May 2019

The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14191&geneProductId=UniProtKB:Q14191

cellular response to starvation

1 reference

9 May 2019

Diverged nuclear localization of Werner helicase in human and mouse cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 reference

9 May 2019

The Werner syndrome protein is a DNA helicase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

response to oxidative stress

NAS

1 reference

9 May 2019

The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

regulation of growth rate

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

cellular response to gamma radiation

1 reference

9 May 2019

Promyelocytic leukemia protein interacts with werner syndrome helicase and regulates double-strand break repair in γ-irradiation-induced DNA damage responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

nucleobase-containing compound metabolic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 reference

9 May 2019

Werner syndrome protein interacts functionally with translesion DNA polymerases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 reference

9 May 2019

The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

double-strand break repair

1 reference

9 May 2019

Promyelocytic leukemia protein interacts with werner syndrome helicase and regulates double-strand break repair in γ-irradiation-induced DNA damage responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

nucleic acid phosphodiester bond hydrolysis

IMP

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

double-strand break repair via homologous recombination

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Asymmetry of DNA replication fork progression in Werner's syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

telomeric D-loop disassembly

5 references

9 May 2019

RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 reference

9 May 2019

A balance between elongation and trimming regulates telomere stability in stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

positive regulation of strand invasion

TAS

1 reference

9 May 2019

The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

3 references

1 January 2018

WRN translocation from nucleolus to nucleoplasm is regulated by SIRT1 and required for DNA repair and the development of chemoresistance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 January 2018

WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

G-quadruplex DNA unwinding

3 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14191&geneProductId=UniProtKB:Q14191

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14191&geneProductId=UniProtKB:Q14191

5 June 2018

Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14191&geneProductId=UniProtKB:Q14191

protein localization to nucleolus

1 reference

9 May 2019

Diverged nuclear localization of Werner helicase in human and mouse cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

DNA synthesis involved in DNA repair

1 reference

9 May 2019

Werner syndrome protein interacts functionally with translesion DNA polymerases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

determination of adult lifespan

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

multicellular organism aging

3 references

9 May 2019

The spectrum of WRN mutations in Werner syndrome patients

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

replication fork processing

3 references

1 January 2018

Asymmetry of DNA replication fork progression in Werner's syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 January 2018

The Werner and Bloom syndrome proteins catalyze regression of a model replication fork

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

3 references

9 May 2019

Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

G-quadruplex DNA unwinding

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

telomeric D-loop disassembly

6 references

1 January 2018

RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 January 2018

RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 January 2018

The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 January 2018

The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 January 2018

Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

cellular response to gamma radiation

regulation of signal transduction by p53 class mediator

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

4 references

9 May 2019

WRN translocation from nucleolus to nucleoplasm is regulated by SIRT1 and required for DNA repair and the development of chemoresistance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

DNA unwinding involved in DNA replication

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14191

EC enzyme number

3.1.-.-

2 references

retrieved

12 October 2015

http://www.uniprot.org/uniprot/Q14191.txt?178

14 November 2015

http://www.uniprot.org/uniprot/Q14191.txt?version=180

Gene Atlas image

PBB GE WRN 205667 at fs.png
732 × 530; 11 KB

0 references

has part(s)

HRDC domain

1 reference

DEAD/DEAH box helicase domain

1 reference

RQC domain

1 reference

ATP-dependent DNA helicase RecQ, zinc-binding domain

1 reference

Helicase superfamily 1/2, ATP-binding domain

1 reference

Helicase Helix-turn-helix domain

1 reference

3'-5' exonuclease domain

1 reference

Helicase, C-terminal

1 reference

D08.811.277.040.025.159.249.500

Commons category

Werner syndrome ATP-dependent helicase, WRN

0 references

Identifiers

MeSH descriptor ID

D000071657

subject named as

Werner Syndrome Helicase

0 references

MeSH tree code

0 references

D08.811.277.352.335.375.875

0 references

D08.811.277.352.365.290.500

0 references

D08.811.399.340.249.500

0 references

0 references

0 references

1 reference

16 November 2018

1 reference

16 November 2018

1 reference

16 November 2018

1 reference

12 October 2018

1 reference

16 January 2019

1 reference

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference