(Q24324195)

multicellular organism aging

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

Emanuela Lucci Cordisco

Emanuela Lucci-Cordisco

16

0 references

Elif Arioglu Oral

Elif Arioglu Oral

13

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Chih-Chao Yang

Chih-Chao Yang

9

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Uwe Wollina

Uwe Wollina

28

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author name string

Shurong Huang

1

0 references

Lin Lee

2

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Nancy B Hanson

3

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Catherine Lenaerts

4

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Holger Hoehn

5

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Martin Poot

6

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Craig D Rubin

7

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Da-Fu Chen

8

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Heike Juch

10

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Thomas Dorn

11

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Roland Spiegel

12

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Mohammed Abid

14

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Carla Battisti

15

0 references

Giovanni Neri

17

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Erin H Steed

18

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Alexa Kidd

19

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William Isley

20

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David Showalter

21

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Janet L Vittone

22

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Alexander Konstantinow

23

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Johannes Ring

24

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Peter Meyer

25

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Sharon L Wenger

26

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Axel von Herbay

27

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Markus Schuelke

29

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Carin R Huizenga

30

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Dru F Leistritz

31

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George M Martin

32

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I Saira Mian

33

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Junko Oshima

The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA

34

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language of work or name

English

0 references

publication date

June 2006

0 references

published in

Human Mutation

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volume

27

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issue

6

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page(s)

558-67

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

p53 modulates RPA-dependent and RPA-independent WRN helicase activity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Diverged nuclear localization of Werner helicase in human and mouse cells

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Werner protein recruits DNA polymerase delta to the nucleolus

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Characterization of the human and mouse WRN 3'-->5' exonuclease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Ku complex interacts with and stimulates the Werner protein

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

p53-mediated apoptosis is attenuated in Werner syndrome cells

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

The Werner syndrome protein is a DNA helicase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Comparative sequence analysis of ribonucleases HII, III, II PH and D

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Mutator phenotype of Werner syndrome is characterized by extensive deletions

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

LMNA mutations in atypical Werner's syndrome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

WRN mutations in Werner syndrome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Excess of rare cancers in Werner syndrome (adult progeria)

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

RecQ helicases: caretakers of the genome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Positional cloning of the Werner's syndrome gene

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Modulation of Werner syndrome protein function by a single mutation in the conserved RecQ domain

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Accumulation of Werner protein at DNA double-strand breaks in human cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Structure and function of RecQ DNA helicases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

A nucleolar targeting sequence in the Werner syndrome protein resides within residues 949-1092.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Werner syndrome diploid fibroblasts are sensitive to 4-nitroquinoline-N-oxide and 8-methoxypsoralen: implications for the disease phenotype.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Werner syndrome cells are sensitive to DNA cross-linking drugs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

What geriatricians should know about the Werner syndrome

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

The Werner syndrome protein is involved in RNA polymerase II transcription

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Differential effects of cytotoxic drugs on mortal and immortalized B-lymphoblastoid cell lines from normal and Werner's syndrome patients

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Abnormal telomere dynamics of B-lymphoblastoid cell strains from Werner's syndrome patients transformed by Epstein-Barr virus

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Werner's syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Genetic syndromes in man with potential relevance to the pathobiology of aging

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

A putative nucleic acid-binding domain in Bloom's and Werner's syndrome helicases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Regulation of WRN helicase activity in human base excision repair

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Werner protein stimulates topoisomerase I DNA relaxation activity

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Werner syndrome protein contains three structure-specific DNA binding domains

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Werner syndrome: characterization of mutations in the WRN gene in an affected family.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1868417

Cytogenetic aspects of Werner syndrome

29 November 2018

1 reference

12 December 2020

Homozygosity mapping of the Werner syndrome locus (WRN)

1 reference

12 December 2020

Cytogenetic aspects of Werner's syndrome lymphocyte cultures

1 reference

12 December 2020

Homozygous and compound heterozygous mutations at the Werner syndrome locus

1 reference

12 December 2020

Analysis of helicase gene mutations in Japanese Werner's syndrome patients

1 reference

12 December 2020

Down-regulation of the defective transcripts of the Werner's syndrome gene in the cells of patients

1 reference

12 December 2020

Mutation and haplotype analyses of the Werner's syndrome gene based on its genomic structure: genetic epidemiology in the Japanese population

1 reference

12 December 2020

Impaired nuclear localization of defective DNA helicases in Werner's syndrome

1 reference

12 December 2020

Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing

1 reference

12 December 2020

Prevalence of Werner's syndrome heterozygotes in Japan

1 reference

12 December 2020

Genetic instability and hematologic disease risk in Werner syndrome patients and heterozygotes

1 reference

12 December 2020

WRN mutations in Werner syndrome

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FHUMU.20337

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1002/HUMU.20337

1 reference

1 reference

1 reference

PubMed publication ID

16673358

1 reference