(Q34187025)

31 July 2017

The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity (English)

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31 July 2017

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7

Vilhelm A Bohr

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31 July 2017

Jeanine A Harrigan

1

1 reference

31 July 2017

Patricia L Opresko

2

1 reference

31 July 2017

Cayetano von Kobbe

3

1 reference

31 July 2017

Padmini S Kedar

4

1 reference

31 July 2017

Rajendra Prasad

5

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31 July 2017

Samuel H Wilson

6

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31 July 2017

language of work or name

English

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publication date

27 March 2003

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Journal of Biological Chemistry

31 July 2017

10

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based on heuristic

inferred from page(s)

published in

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31 July 2017

278

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31 July 2017

22686-22695

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31 July 2017

25

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Genetic analysis of ageing: role of oxidative damage and environmental stresses.

31 July 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Roles of the Werner syndrome protein in pathways required for maintenance of genome stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Werner syndrome diploid fibroblasts are sensitive to 4-nitroquinoline-N-oxide and 8-methoxypsoralen: implications for the disease phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Mutator phenotype of Werner syndrome is characterized by extensive deletions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Homologous recombination resolution defect in werner syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Unwinding the molecular basis of the Werner syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Werner and Bloom helicases are involved in DNA repair in a complementary fashion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Response of base excision repair enzymes to complex DNA lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

21 January 2018

Life without DNA repair

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Suppression of spontaneous mutagenesis in human cells by DNA base excision-repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Involvement of poly(ADP-ribose) polymerase in base excision repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

A role for p53 in base excision repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Replication protein A stimulates long patch DNA base excision repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Werner protein recruits DNA polymerase delta to the nucleolus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Functional interaction between the Werner Syndrome protein and DNA polymerase delta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Functional and physical interaction between WRN helicase and human replication protein A

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Substrate binding by human apurinic/apyrimidinic endonuclease indicates a Briggs-Haldane mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Direct interaction between mammalian DNA polymerase beta and proliferating cell nuclear antigen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Specific interaction of DNA polymerase beta and DNA ligase I in a multiprotein base excision repair complex from bovine testis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Appendix. Gel kinetic analysis of polymerase fidelity in the presence of multiple enzyme DNA encounters

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

The Werner syndrome protein is a DNA helicase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

DNA repair and mutagenesis in Werner syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Selective blockage of the 3'-->5' exonuclease activity of WRN protein by certain oxidative modifications and bulky lesions in DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Protein complexes in nucleotide excision repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

DNA mismatch repair and mutation avoidance pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Weak strand displacement activity enables human DNA polymerase beta to expand CAG/CTG triplet repeats at strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Comparative sequence analysis of ribonucleases HII, III, II PH and D

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Characterization of the human and mouse WRN 3'-->5' exonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

21 January 2018

The 3' 5' exonucleases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Properties of a Recombinant Human Uracil-DNA Glycosylase from the UNG Gene and Evidence that UNG Encodes the Major Uracil-DNA Glycosylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Chromosome instability in lymphocytes from a patient with Werner's syndrome is not associated with DNA repair defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Spontaneous and induced chromosomal instability in Werner syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

dNTP binding site in rat DNA polymerase beta revealed by controlled proteolysis and azido photoprobe cross-linking

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Biochemical characterization of the DNA substrate specificity of Werner syndrome helicase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Passing the baton in base excision repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Unwinding of a DNA triple helix by the Werner and Bloom syndrome helicases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Interactions between the Werner syndrome helicase and DNA polymerase delta specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

Werner syndrome protein. II. Characterization of the integral 3' --> 5' DNA exonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213103200

21 January 2018

Identifiers

DOI

10.1074/JBC.M213103200

1 reference

31 July 2017

1 reference