(Q34519481)

2 August 2017

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title

Roles of the Werner syndrome protein in pathways required for maintenance of genome stability (English)

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2 August 2017

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2

Vilhelm A Bohr

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2 August 2017

Robert M Brosh

1

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2 August 2017

publication date

1 April 2002

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2 August 2017

published in

Experimental Gerontology

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2 August 2017

volume

37

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2 August 2017

issue

4

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2 August 2017

page(s)

491-506

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The Werner syndrome protein is involved in RNA polymerase II transcription

2 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Physical and functional interaction between p53 and the Werner's syndrome protein

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

DNA repair and mutagenesis in Werner syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Functional and physical interaction between WRN helicase and human replication protein A

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

p53 Modulates the exonuclease activity of Werner syndrome protein

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Unwinding of a DNA triple helix by the Werner and Bloom syndrome helicases

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cys/Arg, and its stability in a population of Finnish centenarians

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Polymorphisms at the Werner locus: II. 1074Leu/Phe, 1367Cys/Arg, longevity, and atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Homologous recombination is elevated in some Werner-like syndromes but not during normal in vitro or in vivo senescence of mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

RecQ and RecJ process blocked replication forks prior to the resumption of replication in UV-irradiated Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

The Bloom's syndrome gene product is homologous to RecQ helicases

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

DNA double-strand break repair

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Expansion and length-dependent fragility of CTG repeats in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Mutator phenotype of Werner syndrome is characterized by extensive deletions

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

A novel role in DNA metabolism for the binding of Fen1/Rad27 to PCNA and implications for genetic risk.

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

The Werner syndrome protein is a DNA helicase

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Werner helicase is localized to transcriptionally active nucleoli of cycling cells

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Autoradiographic studies of DNA replication in Werner's syndrome cells

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

RecQ helicase, in concert with RecA and SSB proteins, initiates and disrupts DNA recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

SGS1 is required for telomere elongation in the absence of telomerase

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Requirement of the yeast RTH1 5' to 3' exonuclease for the stability of simple repetitive DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Werner syndrome protein. II. Characterization of the integral 3' --> 5' DNA exonuclease

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Functional interaction between the Werner Syndrome protein and DNA polymerase delta

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Interactions between the Werner syndrome helicase and DNA polymerase delta specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Destabilization of yeast micro- and minisatellite DNA sequences by mutations affecting a nuclease involved in Okazaki fragment processing (rad27) and DNA polymerase delta (pol3-t).

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

DNA damage and repair in telomeres: relation to aging

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I.

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Functional interaction between Ku and the werner syndrome protein in DNA end processing

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

The FEN-1 family of structure-specific nucleases in eukaryotic DNA replication, recombination and repair

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Mutations in the WRN gene in mice accelerate mortality in a p53-null background

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Nucleolar localization of the Werner syndrome protein in human cells

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

What geriatricians should know about the Werner syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Impaired nuclear localization of defective DNA helicases in Werner's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Molecular and epidemiological studies of Werner syndrome in the Japanese population

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

The human homologous pairing protein HPP-1 is specifically stimulated by the cognate single-stranded binding protein hRP-A.

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

A putative nucleic acid-binding domain in Bloom's and Werner's syndrome helicases

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

WRN mutations in Werner syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO.

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Premature aging gene discovered

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Werner's syndrome cell lines are hypersensitive to camptothecin-induced chromosomal damage

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Loss of Werner syndrome protein function promotes aberrant mitotic recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Characterization of a mutant strain of Saccharomyces cerevisiae with a deletion of the RAD27 gene, a structural homolog of the RAD2 nucleotide excision repair gene

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Drug-induced apoptosis is delayed and reduced in XPD lymphoblastoid cell lines: possible role of TFIIH in p53-mediated apoptotic cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Werner's syndrome: a review of recent research with an analysis of connective tissue metabolism, growth control of cultured cells, and chromosomal aberrations

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Growth characteristics of Werner syndrome cells in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Expansions of CAG repeat tracts are frequent in a yeast mutant defective in Okazaki fragment maturation

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Conditional lethality of null mutations in RTH1 that encodes the yeast counterpart of a mammalian 5'- to 3'-exonuclease required for lagging strand DNA synthesis in reconstituted systems

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

p53-mediated apoptosis is attenuated in Werner syndrome cells

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Werner syndrome helicase contains a 5'-->3' exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Werner protein recruits DNA polymerase delta to the nucleolus

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Altered frequency of initiation sites of DNA replication in Werner's syndrome cells

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Mutations in RAD27 define a potential link between G1 cyclins and DNA replication

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

The DNA replication fork in eukaryotic cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

DNA repair fine structure in Werner's syndrome cell lines.

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Molecular biology. DNA ends ReQ-uire attention

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

A role for FEN-1 in nonhomologous DNA end joining: the order of strand annealing and nucleolytic processing events

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Sp1-mediated transcription of the Werner helicase gene is modulated by Rb and p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

FFA-1, a protein that promotes the formation of replication centers within nuclei

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Replication focus-forming activity 1 and the Werner syndrome gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

Positional cloning of the Werner's syndrome gene

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2801%2900227-3

7 January 2021

10.1016/S0531-5565(01)00227-3

Identifiers

DOI

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2 August 2017

1 reference