(Q28596586)

1 February 2017

title

The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events (English)

1 reference

Werner syndrome RecQ like helicase

1 February 2017

main subject

1 reference

positive regulation of strand invasion

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Deanna N. Edwards

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26420422%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

author name string

Amrita Machwe

2

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26420422%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Li Chen

3

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26420422%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Vilhelm A Bohr

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26420422%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

David K Orren

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26420422%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

language of work or name

English

0 references

publication date

30 September 2015

1 reference

1 February 2017

published in

Nature Communications

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26420422%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

volume

6

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26420422%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

page(s)

8331

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26420422%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

3 June 2020

copyright license

start time

30 September 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4589872/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Structural basis for DNA strand separation by the unconventional winged-helix domain of RecQ helicase WRN

17 March 2017

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17 March 2017

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17 March 2017

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17 March 2017

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17 March 2017

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17 March 2017

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Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

17 March 2017

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Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation

17 March 2017

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17 March 2017

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7 April 2017

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7 April 2017

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Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2

7 April 2017

1 reference

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29 September 2017

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Intramolecular telomeric G-quadruplexes dramatically inhibit DNA synthesis by replicative and translesion polymerases, revealing their potential to lead to genetic change

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase.

29 September 2017

1 reference

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29 September 2017

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29 September 2017

1 reference

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Telomere dysfunction as a cause of genomic instability in Werner syndrome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4589872

Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4589872

RecQ family members combine strand pairing and unwinding activities to catalyze strand exchange

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4589872

Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4589872

TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4589872

Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4589872

The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4589872

T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4589872

Lessons from human progeroid syndromes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4589872

Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4589872

The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4589872

Monovalent cation-induced structure of telomeric DNA: the G-quartet model

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4589872

Guanine quartet structures

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4589872

The distribution of sodium, potassium and chloride in the nucleus and cytoplasm of Bufo bufo oocytes measured by electron microprobe analysis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4589872

Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4589872

Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4589872

Werner syndrome protein contains three structure-specific DNA binding domains

3 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS9331

Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts

21 January 2018

1 reference

12 December 2020

Structure and stability of human telomeric sequence

1 reference

12 December 2020

1 reference

12 December 2020

DNase I footprinting and enhanced exonuclease function of the bipartite Werner syndrome protein (WRN) bound to partially melted duplex DNA

1 reference

12 December 2020

The Concentrations of Water, Sodium and Potassium in the Nucleus and Cytoplasm of Amphibian Oocytes

1 reference

12 December 2020

Biochemical characterization of the DNA substrate specificity of Werner syndrome helicase

1 reference

12 December 2020

Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n

1 reference

12 December 2020

Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing

1 reference

12 December 2020

Telomere shortening and decline in replicative potential as a function of donor age in human adrenocortical cells

1 reference

12 December 2020

Effects of ethionine on adenosine triphosphate levels and ionic composition of liver cell nuclei

1 reference

12 December 2020

Identifiers

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26420422%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

3 June 2020

ADS bibcode

2015NatCo...6.8331E

0 references

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26420422%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26420422%20AND%20SRC:MED&resulttype=core&format=json