(Q33959427)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20215438%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

title

Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20215438%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20215438%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

author name string

Gerald J Nora

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20215438%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Noah A Buncher

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20215438%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

language of work or name

English

0 references

publication date

9 March 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20215438%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

published in

Nucleic Acids Research

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20215438%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

volume

38

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20215438%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

issue

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20215438%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

page(s)

3984-3998

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20215438%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution-NonCommercial 2.5 Generic

19 January 2020

copyright license

start time

7 November 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2896529/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Human RAP1 inhibits non-homologous end joining at telomeres

5 July 2018

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RecQ helicases: multifunctional genome caretakers

5 July 2018

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The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

TRF2 promotes, remodels and protects telomeric Holliday junctions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

How shelterin protects mammalian telomeres

5 July 2018

1 reference

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The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicase

5 July 2018

1 reference

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Translocation and unwinding mechanisms of RNA and DNA helicases

5 July 2018

1 reference

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WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

Telomere ResQue and preservation--roles for the Werner syndrome protein and other RecQ helicases.

5 July 2018

1 reference

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Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases.

5 July 2018

1 reference

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Fission yeast Taz1 and RPA are synergistically required to prevent rapid telomere loss

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

Telomere dysfunction as a cause of genomic instability in Werner syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

A topological mechanism for TRF2-enhanced strand invasion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

The Werner and Bloom syndrome proteins catalyze regression of a model replication fork

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

Replication fork regression in repetitive DNAs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

The stacked-X DNA Holliday junction and protein recognition.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

Holliday junction dynamics and branch migration: single-molecule analysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

Observing spontaneous branch migration of Holliday junctions one step at a time

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

Telomeric DNA in ALT cells is characterized by free telomeric circles and heterogeneous t-loops

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

Homologous recombination generates T-loop-sized deletions at human telomeres

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

Homologous recombination resolution defect in werner syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

The processing of Holliday junctions by BLM and WRN helicases is regulated by p53

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

Structural analysis of DNA replication fork reversal by RecG

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

Identification of human Rap1: implications for telomere evolution

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

Processing of recombination intermediates by the RecG and RuvAB proteins of Escherichia coli

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

A simple, sensitive assay to detect DNA-protein crosslinks in intact cells and in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

Sumoylation of RecQ helicase controls the fate of dysfunctional telomeres.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

Comparison between TRF2 and TRF1 of their telomeric DNA-bound structures and DNA-binding activities.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

Structure of a multisubunit complex that promotes DNA branch migration.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2896529

Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20215438

12 December 2020

inferred from PubMed ID database lookup

The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20215438

12 December 2020

inferred from PubMed ID database lookup

The basic domain of TRF2 directs binding to DNA junctions irrespective of the presence of TTAGGG repeats

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20215438

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1093/NAR/GKQ144

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20215438%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20215438%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

20215438

1 reference