(Q28117562)

4 January 2017

title

FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1 (English)

1 reference

4 January 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752685%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Javier Rodríguez

2

1 reference

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10 June 2020

Christina Pickel

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752685%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Stephen P Burr

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752685%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Karen A Nolan

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752685%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Miguel Cavadas

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752685%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Doug N Halligan

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752685%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

James A Nathan

11

1 reference

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10 June 2020

Daniel J. Peet

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752685%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Alex von Kriegsheim

14

1 reference

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10 June 2020

Eoin P Cummins

15

1 reference

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10 June 2020

Cormac T Taylor

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752685%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

9

Bianca Crifo

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752685%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

author name string

Jacqueline-Alba Fabrizio

5

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752685%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Patrick Spielmann

7

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752685%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Roland H Wenger

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752685%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

language of work or name

English

0 references

publication date

1 January 2016

1 reference

4 January 2017

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752685%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

volume

14

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752685%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

issue

1

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752685%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

page(s)

e1002347

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752685%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

10 June 2020

copyright license

start time

11 January 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

20 March 2017

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20 March 2017

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20 March 2017

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Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1

20 March 2017

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Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

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Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response

20 March 2017

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20 March 2017

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E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1

20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

20 March 2017

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20 March 2017

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PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192

20 March 2017

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20 March 2017

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Consequences of IkappaB alpha hydroxylation by the factor inhibiting HIF (FIH)

20 March 2017

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20 March 2017

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7 April 2017

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7 April 2017

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Oxygen-dependent hydroxylation by FIH regulates the TRPV3 ion channel

7 April 2017

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29 September 2017

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Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase

29 September 2017

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29 September 2017

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Monoubiquitination is critical for ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (Otub1) to suppress UbcH5 enzyme and stabilize p53 protein.

29 September 2017

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29 September 2017

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Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways.

29 September 2017

1 reference

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OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4709136

Targeting the HIF pathway in inflammation and immunity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4709136

Factor inhibiting HIF-1 (FIH-1) modulates protein interactions of apoptosis-stimulating p53 binding protein 2 (ASPP2).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4709136

Hydroxylase-dependent regulation of the NF-κB pathway.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4709136

Metabolism of inflammation limited by AMPK and pseudo-starvation

29 September 2017

1 reference

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The International Mouse Phenotyping Consortium: past and future perspectives on mouse phenotyping

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4709136

Factor inhibiting HIF (FIH) recognizes distinct molecular features within hypoxia-inducible factor-α (HIF-α) versus ankyrin repeat substrates

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4709136

The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4709136

Normoxic destabilization of ATF-4 depends on proteasomal degradation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4709136

FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4709136

PANTHER pathway: an ontology-based pathway database coupled with data analysis tools

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4709136

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29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4709136

Regulation of oxygen homeostasis by hypoxia-inducible factor 1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4709136

Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4709136

Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4709136

Hypoxia-responsive transcription factors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4709136

Characterization of ankyrin repeat-containing proteins as substrates of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible transcription factor.

29 September 2017

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1002347

Clustal Omega, accurate alignment of very large numbers of sequences.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1002347

Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/26752685

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PBIO.1002347

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752685%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752685%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752685%20AND%20SRC:MED&resulttype=core&format=json