(Q28144745)

English

MEK kinase 2 binds and activates protein kinase C-related kinase 2. Bifurcation of kinase regulatory pathways at the level of an MAPK kinase kinase

scientific article (publication date: 11 August 2000)

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scholarly article

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MEK kinase 2 binds and activates protein kinase C-related kinase 2. Bifurcation of kinase regulatory pathways at the level of an MAPK kinase kinase (English)

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author name string

W Sun

1

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S Vincent

2

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J Settleman

3

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G L Johnson

4

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language of work or name

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publication date

11 August 2000

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Journal of Biological Chemistry

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275

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32

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24421-8

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Cloning and expression patterns of two members of a novel protein-kinase-C-related kinase family

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Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho

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The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization

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Effector domain mutants of Rho dissociate cytoskeletal changes from nuclear signaling and cellular transformation

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Rho GTPases and the actin cytoskeleton

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Specific association between the human DNA repair proteins XPA and ERCC1

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10 Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast

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A novel genetic system to detect protein-protein interactions

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Deletion analysis of GAL4 defines two transcriptional activating segments

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14-3-3 proteins interact with specific MEK kinases

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Loop 6 of RhoA confers specificity for effector binding, stress fiber formation, and cellular transformation

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Mutational analysis of the regulatory mechanism of PKN: the regulatory region of PKN contains an arachidonic acid-sensitive autoinhibitory domain

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KSR stimulates Raf-1 activity in a kinase-independent manner

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Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression

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KSR, a novel protein kinase required for RAS signal transduction

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KSR modulates signal propagation within the MAPK cascade

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Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK.

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Identifiers

10.1074/JBC.M003148200

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