(Q28193566)

1

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Graham Palmer

2

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Gang Wu

3

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Sheng Peng

4

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Nicole M Okeley

5

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Richard J Kulmacz

Journal of Biological Chemistry

7

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language of work or name

English

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publication date

11 October 2002

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published in

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volume

277

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issue

41

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page(s)

38311-21

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cites work

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Comparison of recombinant cyclooxygenase-2 to native isoforms: aspirin labeling of the active site.

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Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions

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Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo

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Spectroscopic evidence for reaction of prostaglandin H synthase-1 tyrosyl radical with arachidonic acid.

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Structural characterization of a pentadienyl radical intermediate formed during catalysis by prostaglandin H synthase-2.

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Tyrosyl radicals in prostaglandin H synthase-1 and -2.

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The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

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Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2

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Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

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The productive conformation of arachidonic acid bound to prostaglandin synthase

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Analysis of hydroperoxide-induced tyrosyl radicals and lipoxygenase activity in aspirin-treated human prostaglandin H synthase-2

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Comparison of hydroperoxide initiator requirements for the cyclooxygenase activities of prostaglandin H synthase-1 and -2.

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Structural characterization of alkyl and peroxyl radicals in solutions of purple lipoxygenase.

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Mutation of serine-516 in human prostaglandin G/H synthase-2 to methionine or aspirin acetylation of this residue stimulates 15-R-HETE synthesis

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Different catalytically competent arrangements of arachidonic acid within the cyclooxygenase active site of prostaglandin endoperoxide H synthase-1 lead to the formation of different oxygenated products

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Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349

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Spatial requirements for 15-(R)-hydroxy-5Z,8Z,11Z, 13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2. Why acetylated COX-1 does not synthesize 15-(R)-hete

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Deuterium isotope effects on noncovalent interactions between molecules.

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Synthesis of isotopically labeled arachidonic acids to probe the reaction mechanism of prostaglandin H synthase

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The purification of a respiratory oxidase complex from escherichia coli

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Isolation and covalent structure of the aspirin-modified, active-site region of prostaglandin synthetase

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Higher oxidation states of prostaglandin H synthase. EPR study of a transient tyrosyl radical in the enzyme during the peroxidase reaction

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Higher oxidation states of prostaglandin H synthase. Rapid electronic spectroscopy detected two spectral intermediates during the peroxidase reaction with prostaglandin G2

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Structural characterization of arachidonyl radicals formed by prostaglandin H synthase-2 and prostaglandin H synthase-1 reconstituted with mangano protoporphyrin IX

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Reaction and free radical kinetics of prostaglandin H synthase with manganese protoporphyrin IX as the prosthetic group

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Protein-tyrosyl radical interactions in photosystem II studied by electron spin resonance and electron nuclear double resonance spectroscopy: comparison with ribonucleotide reductase and in vitro tyrosine

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Stereospecificity of hydrogen abstraction in the conversion of arachidonic acid to 15R-HETE by aspirin-treated cyclooxygenase-2. Implications for the alignment of substrate in the active site

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Lysine 2,3-aminomutase and trans-4,5-dehydrolysine: characterization of an allylic analogue of a substrate-based radical in the catalytic mechanism

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