(Q28202882)

1

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Gavan Holloway

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Dale A McPhee

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Phoebe Ellis

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Michael Lidman

The conserved core of human immunodeficiency virus type 1 Nef is essential for association with Lck and for enhanced viral replication in T-lymphocytes

6

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language of work or name

English

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publication date

April 2003

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published in

Journal of Biosciences

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volume

28

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issue

3

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page(s)

323-35

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cites work

1 reference

12 December 2020

Human immunodeficiency virus type 1 Nef protein down-regulates transcription factors NF-kappa B and AP-1 in human T cells in vitro after T-cell receptor stimulation

1 reference

12 December 2020

Association of p56lck with IL-2 receptor beta chain is critical for the IL-2-induced activation of p56lck

1 reference

12 December 2020

The downregulation of CD4 and MHC-I by primate lentiviruses: a paradigm for the modulation of cell surface receptors

1 reference

12 December 2020

Modulation of HIV-1 infectivity by MAPK, a virion-associated kinase

1 reference

12 December 2020

Alterations of the lymphocyte-specific protein tyrosine kinase (p56lck) during T-cell activation

1 reference

12 December 2020

Plasma membrane rafts play a critical role in HIV-1 assembly and release

1 reference

12 December 2020

The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages

1 reference

12 December 2020

Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway

1 reference

12 December 2020

Human immunodeficiency virus type 1 glycoprotein precursor retains a CD4-p56lck complex in the endoplasmic reticulum

1 reference

12 December 2020

Palmitoylation of the HIV-1 envelope glycoprotein is critical for viral infectivity

1 reference

12 December 2020

HIV-1 Nef promotes survival of myeloid cells by a Stat3-dependent pathway.

1 reference

12 December 2020

Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain

1 reference

12 December 2020

The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens

1 reference

12 December 2020

Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

1 reference

12 December 2020

Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines

1 reference

12 December 2020

The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling

1 reference

12 December 2020

HIV-1 Nef association with cellular serine kinase correlates with enhanced virion infectivity and efficient proviral DNA synthesis

1 reference

12 December 2020

The human immunodeficiency virus type 1 Nef protein binds the Src-related tyrosine kinase Lck SH2 domain through a novel phosphotyrosine independent mechanism.

1 reference

12 December 2020

HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.

1 reference

12 December 2020

PAK-family kinases regulate cell and actin polarization throughout the cell cycle of Saccharomyces cerevisiae

1 reference

12 December 2020

CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration.

1 reference

12 December 2020

Nef 27, but not the Nef 25 isoform of human immunodeficiency virus-type 1 pNL4.3 down-regulates surface CD4 and IL-2R expression in peripheral blood mononuclear cells and transformed T cells

1 reference

12 December 2020

The Nef protein of primate lentiviruses

1 reference

12 December 2020

Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules

1 reference

12 December 2020

Simian immunodeficiency virus and human immunodeficiency virus type 1 nef proteins show distinct patterns and mechanisms of Src kinase activation

1 reference

12 December 2020

Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking

1 reference

12 December 2020

Lentivirus Nef specifically activates Pak2.

1 reference

12 December 2020

Mechanism for down-regulation of CD28 by Nef.

1 reference

12 December 2020

HIV-1 Nef protein inhibits the recruitment of AP-1 DNA-binding activity in human T-cells

1 reference

12 December 2020

CD4 down-modulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef.

1 reference

12 December 2020

SH3-Domain binding function of HIV-1 Nef is required for association with a PAK-related kinase

1 reference

12 December 2020

Lipid rafts and HIV-1: from viral entry to assembly of progeny virions.

1 reference

12 December 2020

The human immunodeficiency virus: infectivity and mechanisms of pathogenesis

1 reference

12 December 2020

A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity

1 reference

12 December 2020

Expression of simian immunodeficiency virus nef in immune cells of transgenic mice leads to a severe AIDS-like disease

1 reference

12 December 2020

CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals

1 reference

12 December 2020

HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages

1 reference

12 December 2020

Hck SH3 domain-dependent abrogation of Nef-induced class 1 MHC down-regulation

1 reference

12 December 2020

Microtubule integrity regulates Pak leading to Ras-independent activation of Raf-1. insights into mechanisms of Raf-1 activation

1 reference

12 December 2020

Use of the two-hybrid system to identify cellular partners of the HIV1 Nef protein.

1 reference

12 December 2020

The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR.

1 reference

12 December 2020

The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane

1 reference

12 December 2020

HIV-1 Nef increases T cell activation in a stimulus-dependent manner

1 reference

12 December 2020

Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice

1 reference

12 December 2020

Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation

1 reference

12 December 2020

Myristoylation-dependent binding of HIV-1 Nef to CD4.

1 reference

12 December 2020

In vitro binding and phosphorylation of human immunodeficiency virus type 1 Nef protein by serine/threonine protein kinase

1 reference

12 December 2020

HIV-2 and SIV nef proteins target different Src family SH3 domains than does HIV-1 Nef because of a triple amino acid substitution

1 reference

12 December 2020

Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis

1 reference

12 December 2020

Virological importance of the protease-cleavage site in human immunodeficiency virus type 1 Nef is independent of both intravirion processing and CD4 down-regulation.

1 reference

12 December 2020

Identification of a beta-type adaptin in plant clathrin-coated vesicles.

1 reference

12 December 2020

Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection

1 reference

12 December 2020

Requirement of p56lck in T-cell receptor/CD3-mediated apoptosis and Fas-ligand induction in Jurkat cells.

1 reference

12 December 2020

Protein Kinase C-mediated Phosphorylation of HIV-I Nef in Human Cell Lines

1 reference

12 December 2020

Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene

1 reference

12 December 2020

HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals

1 reference

12 December 2020

The Primate Lentivirus-Encoded Nef Protein Can Regulate Several Steps of the Viral Replication Cycle

1 reference

12 December 2020

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4

1 reference

12 December 2020

The dileucine-based sorting motif in HIV-1 Nef is not required for down-regulation of class I MHC.

1 reference

12 December 2020

T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases

1 reference

12 December 2020

Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques

1 reference

12 December 2020

Neurovirulent simian immunodeficiency virus incorporates a Nef-associated kinase activity into virions

1 reference

12 December 2020

Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes

1 reference

12 December 2020

Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIX

1 reference

12 December 2020

Molecular analysis of the cytoplasmic domain of CD4: overlapping but noncompetitive requirement for lck association and down-regulation by Nef.

1 reference

12 December 2020

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

1 reference

12 December 2020

The negative effect of human immunodeficiency virus type 1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4.

1 reference

12 December 2020

Down-modulation of the costimulatory molecule, CD28, is a conserved activity of multiple SIV Nefs and is dependent on histidine 196 of Nef.

1 reference

12 December 2020

Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

1 reference

12 December 2020

p21-activated protein kinase gamma-PAK suppresses programmed cell death of BALB3T3 fibroblasts

1 reference

12 December 2020

The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL 2 production reflects events occurring at a pre-translational level

1 reference

12 December 2020

HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell

1 reference

12 December 2020

The structure and signalling functions of the invariant T cell receptor components

1 reference

12 December 2020

A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4

1 reference

12 December 2020

Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients

1 reference

12 December 2020

Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein

1 reference

12 December 2020

Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

1 reference

12 December 2020

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes

1 reference

12 December 2020

Signal transduction by lymphocyte antigen receptors

1 reference

12 December 2020

Peptidoglycan induces transcription and secretion of TNF-alpha and activation of lyn, extracellular signal-regulated kinase, and rsk signal transduction proteins in mouse macrophages

1 reference

12 December 2020

HIV-1 Nef activity in murine T cells. CD4 modulation and positive enhancement.

1 reference

12 December 2020

Lipopolysaccharide-induced cytokine production in human monocytes: role of tyrosine phosphorylation in transmembrane signal transduction

1 reference

12 December 2020

Regulation of apoptosis in immune cells

1 reference

12 December 2020

Stable expression of human immunodeficiency virus type 1 Nef confers resistance against Fas-mediated apoptosis

1 reference

12 December 2020

Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes

1 reference

12 December 2020

Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis.

1 reference

12 December 2020

Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity

1 reference

12 December 2020

Activation of the PAK-related kinase by human immunodeficiency virus type 1 Nef in primary human peripheral blood lymphocytes and macrophages leads to phosphorylation of a PIX-p95 complex

1 reference

12 December 2020

SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1.

1 reference

12 December 2020

Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity

1 reference

12 December 2020

Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions

1 reference

12 December 2020

Biochemical and biologic characterization of murine monocyte chemoattractant protein-1. Identification of two functional domains

1 reference

12 December 2020

The Src family of tyrosine protein kinases in hemopoietic signal transduction

1 reference

12 December 2020

Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

1 reference

12 December 2020

Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell

1 reference

12 December 2020

HIV-1 Nef inhibits a common activation pathway in NIH-3T3 cells.

1 reference

12 December 2020

Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family

1 reference

12 December 2020

HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization

1 reference

12 December 2020

The HIV nef protein associates with protein kinase C theta

1 reference

12 December 2020

Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail

1 reference

12 December 2020

Nef enhances human immunodeficiency virus type 1 infectivity resulting from intervirion fusion: evidence supporting a role for Nef at the virion envelope

1 reference

12 December 2020

Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines.

1 reference

12 December 2020

A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains

1 reference

12 December 2020

Mechanisms of HIV-1 to escape from the host immune surveillance.

1 reference

12 December 2020

The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck.

1 reference

12 December 2020

A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein

1 reference

12 December 2020

T-lymphocyte interleukin 2-dependent tyrosine protein kinase signal transduction involves the activation of p56lck

1 reference

12 December 2020

The N-Terminus of Nef from HIV-1/SIV Associates with a Protein Complex Containing Lck and a Serine Kinase

1 reference

12 December 2020

Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

1 reference

12 December 2020

Analysis of Nef-induced MHC-I endocytosis

1 reference

12 December 2020

Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators

1 reference

12 December 2020

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

1 reference

12 December 2020

Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes

1 reference

12 December 2020

Physical and functional interaction of Nef with Lck. HIV-1 Nef-induced T-cell signaling defects.

1 reference

12 December 2020

Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA.

1 reference

12 December 2020

Human immunodeficiency virus type 1 Vpu protein regulates the formation of intracellular gp160-CD4 complexes

1 reference

12 December 2020

Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain

1 reference

12 December 2020