(Q28207327)

1

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Philipp Mayer-Kuckuk

2

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Gina Capiaux

3

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Tulin Budak-Alpdogan

4

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Joseph R Bertino

Biochimica et Biophysica Acta

6

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language of work or name

English

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publication date

18 July 2002

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published in

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volume

1587

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issue

2-3

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page(s)

164-73

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cites work

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Dihydrofolate reductase as a therapeutic target

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Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake

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A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport

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Basis for natural resistance to methotrexate in human acute non-lymphocytic leukemia

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The role of folylpolyglutamate synthetase and gamma-glutamyl hydrolase in altering cellular folyl- and antifolylpolyglutamates

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Cytologic evidence for gene amplification in methotrexate-resistant cells obtained from a patient with ovarian adenocarcinoma

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Unstable Methotrexate Resistance in Human Small-Cell Carcinoma Associated with Double Minute Chromosomes

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Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

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Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

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Isolation and expression of an altered mouse dihydrofolate reductase cDNA.

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Phenotypic Expression in Escherichia coli and Nucleotide Sequence of Two Chinese Hamster Lung Cell cDNAs Encoding Different Dihydrofolate Reductases

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Isolation and characterization of a variant dihydrofolate reductase cDNA from methotrexate-resistant murine L5178Y cells

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The dihydrofolate reductase-thymidylate synthetase gene in the drug resistance of malaria parasites

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Increase of dihydrofolate reductase activity in cultured mammalian cells after exposure to methotrexate

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Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase

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Dihydrofolate reductase protein inhibits its own translation by binding to dihydrofolate reductase mRNA sequences within the coding region

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E2F: a link between the Rb tumor suppressor protein and viral oncoproteins

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Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival

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Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin

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Immunohistochemical quantitation of thymidylate synthase expression in colorectal cancer metastases predicts for clinical outcome to fluorouracil-based chemotherapy

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Higher levels of thymidylate synthase gene expression are observed in pulmonary as compared with hepatic metastases of colorectal adenocarcinoma

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7 January 2021

Identification of an RNA binding site for human thymidylate synthase

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Isolation and characterization of thymitaq (AG337) and 5-fluoro-2-deoxyuridylate-resistant mutants of human thymidylate synthase from ethyl methanesulfonate-exposed human sarcoma HT1080 cells

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Random sequence mutagenesis and resistance to 5-fluorouridine in human thymidylate synthases

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7 January 2021

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Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

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Retroviral transduction of human dihydropyrimidine dehydrogenase cDNA confers resistance to 5-fluorouracil in murine hematopoietic progenitor cells and human CD34+-enriched peripheral blood progenitor cells

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7 January 2021

Post-transplant methotrexate administration leads to improved curability of mice bearing a mammary tumor transplanted with marrow transduced with a mutant human dihydrofolate reductase cDNA

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7 January 2021

Gene therapy utilizing drug resistance genes: a review

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7 January 2021

Expression of a novel double-mutant dihydrofolate reductase-cytidine deaminase fusion gene confers resistance to both methotrexate and cytosine arabinoside

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Generation of dual resistance to 4-hydroperoxycyclophosphamide and methotrexate by retroviral transfer of the human aldehyde dehydrogenase class 1 gene and a mutated dihydrofolate reductase gene

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7 January 2021

Cells exposed to antifolates show increased cellular levels of proteins fused to dihydrofolate reductase: a method to modulate gene expression

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7 January 2021