(Q28210107)

4

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author name string

Masao Saitoh

1

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Nicholas Pullen

2

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Patrick B Dennis

5

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George Thomas

Journal of Biological Chemistry

6

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language of work or name

English

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publication date

31 May 2002

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published in

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volume

277

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issue

22

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page(s)

20104-12

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cites work

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Mammalian TOR: a homeostatic ATP sensor

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Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

21 January 2018

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Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

21 January 2018

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dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.

21 January 2018

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Drosophila S6 kinase: a regulator of cell size

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Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice

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The modular phosphorylation and activation of p70s6k.

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Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs

21 January 2018

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Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites

21 January 2018

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Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation

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Dual requirement for a newly identified phosphorylation site in p70s6k

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The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases

21 January 2018

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3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

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Phosphorylation and activation of p70s6k by PDK1

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Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro

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Phosphorylation sites in the autoinhibitory domain participate in p70(s6k) activation loop phosphorylation

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3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

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Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

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Oncogenic kinase signalling

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Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation

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Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

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Construction and characterization of a conditionally active version of the serine/threonine kinase Akt.

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Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

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Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies

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Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

21 January 2018

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A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

21 January 2018

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Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

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Control of p70 s6 kinase by kinase activity of FRAP in vivo

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Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes

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PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

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Activation of p70/p85 S6 kinase by a pathway independent of p21ras

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Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

21 January 2018

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Atypical protein kinase Clambda binds and regulates p70 S6 kinase

21 January 2018

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Differential regulation by calcium reveals distinct signaling requirements for the activation of Akt and p70S6k

21 January 2018

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p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex

21 January 2018

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The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1.

21 January 2018

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Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway

21 January 2018

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Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase

21 January 2018

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The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

21 January 2018

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FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse

21 January 2018

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PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

21 January 2018

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Intracellular signalling: PDK1--a kinase at the hub of things

21 January 2018

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The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

21 January 2018

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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

21 January 2018

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Akt activation by growth factors is a multiple-step process: the role of the PH domain

21 January 2018

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Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinasein Vivoat Thr-412 as well as Thr-252

21 January 2018

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p70s6k function is essential for G1 progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201745200