(Q28218908)

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Identifying the links between obesity, insulin resistance and beta-cell function: potential role of adipocyte-derived cytokines in the pathogenesis of type 2 diabetes

scientific article (publication date: June 2002)

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Europe PubMed Central

Identifying the links between obesity, insulin resistance and beta-cell function: potential role of adipocyte-derived cytokines in the pathogenesis of type 2 diabetes (English)

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DOI.org query endpoint

https://doi.org/10.1046%2FJ.1365-2362.32.S3.4.X

26 March 2017

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type 2 diabetes

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1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

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based on heuristic

inferred from title

insulin resistance

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based on heuristic

inferred from title

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author name string

A S Greenberg

1

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M L McDaniel

2

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A. S. Greenberg

1

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DOI.org query endpoint

https://doi.org/10.1046%2FJ.1365-2362.32.S3.4.X

26 March 2017

M. L. McDaniel

2

1 reference

DOI.org query endpoint

https://doi.org/10.1046%2FJ.1365-2362.32.S3.4.X

26 March 2017

language of work or name

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publication date

June 2002

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DOI.org query endpoint

https://doi.org/10.1046%2FJ.1365-2362.32.S3.4.X

26 March 2017

European Journal of Clinical Investigation

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DOI.org query endpoint

https://doi.org/10.1046%2FJ.1365-2362.32.S3.4.X

26 March 2017

32 Suppl 3

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32

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DOI.org query endpoint

https://doi.org/10.1046%2FJ.1365-2362.32.S3.4.X

26 March 2017

s3

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DOI.org query endpoint

https://doi.org/10.1046%2FJ.1365-2362.32.S3.4.X

26 March 2017

24-34

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DOI.org query endpoint

https://doi.org/10.1046%2FJ.1365-2362.32.S3.4.X

26 March 2017

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

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21 April 2017

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

1 reference

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21 April 2017

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

1 reference

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21 April 2017

TOR, a central controller of cell growth

1 reference

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21 April 2017

The hormone resistin links obesity to diabetes

1 reference

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21 April 2017

The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation

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21 April 2017

Serum immunoreactive-leptin concentrations in normal-weight and obese humans

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21 April 2017

Decreased Insulin Secretion and Increased Insulin Resistance Are Independently Related to the 7-Year Risk of NIDDM in Mexican-Americans

1 reference

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21 January 2018

The importance of insulin resistance in the pathogenesis of type 2 diabetes mellitus

1 reference

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21 January 2018

The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity.

1 reference

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21 January 2018

From obesity to diabetes: why, when and who?

1 reference

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21 January 2018

Clinical review 26: Insulin resistance in obese and nonobese man.

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21 January 2018

TNF-alpha and insulin resistance: summary and future prospects

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21 January 2018

Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo.

1 reference

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21 January 2018

Elevated Levels of Interleukin 6 Are Reduced in Serum and Subcutaneous Adipose Tissue of Obese Women after Weight Loss

1 reference

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21 January 2018

Role of fatty acids in the pathogenesis of insulin resistance and NIDDM.

1 reference

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21 January 2018

Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia

1 reference

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21 January 2018

IL-1 produced and released endogenously within human islets inhibits beta cell function

1 reference

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21 January 2018

TNF-alpha inhibits glucose-induced insulin secretion in a pancreatic beta-cell line (INS-1).

1 reference

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21 January 2018

Inhibition of insulin secretion from rat islets of Langerhans by interleukin-6. An effect distinct from that of interleukin-1.

1 reference

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21 January 2018

Stimulation of insulin secretion by long-chain free fatty acids. A direct pancreatic effect

1 reference

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21 January 2018

A multicomponent insulin response sequence mediates a strong repression of mouse glucose-6-phosphatase gene transcription by insulin

1 reference

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21 January 2018

Insulin antiapoptotic signaling involves insulin activation of the nuclear factor kappaB-dependent survival genes encoding tumor necrosis factor receptor-associated factor 2 and manganese-superoxide dismutase.

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21 January 2018

The role of the IGF-I receptor in the growth and transformation of mammalian cells.

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21 January 2018

Insulin signaling and action in fat cells: associations with insulin resistance and type 2 diabetes

1 reference

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21 January 2018

Insulin action in skeletal muscle from patients with NIDDM.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.4.X

21 January 2018

Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.4.X

21 January 2018

Glucose-induced insulin receptor tyrosine phosphorylation in insulin-secreting beta-cells

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.4.X

21 January 2018

The insulin signalling system and the IRS proteins

1 reference

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21 January 2018

Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.4.X

21 January 2018

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.4.X

21 January 2018

Tumor necrosis factor alpha inhibits signaling from the insulin receptor

1 reference

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21 January 2018

Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

1 reference

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21 January 2018

An endotoxin-induced serum factor that causes necrosis of tumors

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21 January 2018

The tumor necrosis factor ligand and receptor families.

1 reference

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21 January 2018

The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.4.X

21 January 2018

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance

1 reference

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21 January 2018

Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.4.X

21 January 2018

Tumor necrosis factor stimulates hepatic lipid synthesis and secretion

1 reference

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21 January 2018

Effects of troglitazone on fat distribution in the treatment of male type 2 diabetes.

1 reference

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21 January 2018

Insulin resistance and its treatment by thiazolidinediones

1 reference

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21 January 2018

Mechanism of free fatty acid-induced insulin resistance in humans

1 reference

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21 January 2018

Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin

1 reference

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21 January 2018

Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity

1 reference

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21 January 2018

Dose effects of recombinant human interleukin-6 on pituitary hormone secretion and energy expenditure.

1 reference

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21 January 2018

The expression of TNF alpha by human muscle. Relationship to insulin resistance

1 reference

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21 January 2018

Down-regulation by troglitazone of hepatic tumor necrosis factor-alpha and interleukin-6 mRNA expression in a murine model of non-insulin-dependent diabetes

1 reference

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21 January 2018

Effects of tumor necrosis factor-alpha on glucose metabolism in cultured human muscle cells from nondiabetic and type 2 diabetic subjects

1 reference

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21 January 2018

The importance of the beta-cell in the pathogenesis of type 2 diabetes mellitus

1 reference

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21 January 2018

Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.

1 reference

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21 January 2018

Fatty acids, lipotoxicity and insulin secretion

1 reference

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21 January 2018

Interactions between insulin resistance and insulin secretion in the development of glucose intolerance

1 reference

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21 January 2018

Interrelationship of changes in islet nicotine adeninedinucleotide, insulin secretion, and cell viability induced by interleukin-1 beta

1 reference

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21 January 2018

Nitric oxide and cellular respiration

1 reference

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21 January 2018

Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide

1 reference

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21 January 2018

Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans

1 reference

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21 January 2018

Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase

1 reference

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21 January 2018

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

1 reference

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21 January 2018

Attenuation of mammalian target of rapamycin activity by increased cAMP in 3T3-L1 adipocytes

1 reference

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21 January 2018

Insulin mediates glucose-stimulated phosphorylation of PHAS-I by pancreatic beta cells. An insulin-receptor mechanism for autoregulation of protein synthesis by translation

1 reference

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21 January 2018

Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells

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21 January 2018

Relative hypoglycemia and hyperinsulinemia in mice with heterozygous lipoprotein lipase (LPL) deficiency. Islet LPL regulates insulin secretion

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21 January 2018

Glucose and insulin stimulate heparin-releasable lipoprotein lipase activity in mouse islets and INS-1 cells. A potential link between insulin resistance and beta-cell dysfunction

1 reference

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21 January 2018

Overexpression of perilipin A and B blocks the ability of tumor necrosis factor alpha to increase lipolysis in 3T3-L1 adipocytes

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21 January 2018

Redefining the clinical management of type 2 diabetes: matching therapy to pathophysiology

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21 January 2018

Metabolic effects of troglitazone on fructose-induced insulin resistance in the rat.

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21 January 2018

Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects

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21 January 2018

Effect of new oral antidiabetic agent CS-045 on glucose tolerance and insulin secretion in patients with NIDDM.

1 reference

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21 January 2018

Response of pancreatic beta-cells to improved insulin sensitivity in women at high risk for type 2 diabetes

1 reference

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21 January 2018

Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance

1 reference

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21 January 2018

Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats

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21 January 2018

PPAR-gamma agonists: therapeutic role in diabetes, inflammation and cancer

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21 January 2018

Inflammatory cytokines stimulate vascular smooth muscle cells locomotion and growth by enhancing alpha5beta1 integrin expression and function.

1 reference

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21 January 2018

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

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21 January 2018

BRL 49653 blocks the lipolytic actions of tumor necrosis factor-alpha: a potential new insulin-sensitizing mechanism for thiazolidinediones

1 reference

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21 January 2018

Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling

1 reference

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21 January 2018

Relationship of leptin concentration to gender, menopause, age, diabetes, and fat mass in African Americans.

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21 January 2018

Resistin gene expression in human adipocytes is not related to insulin resistance.

1 reference

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21 January 2018

PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein

1 reference

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21 January 2018

Synthetic peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients

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21 January 2018

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