(Q28241967)

12 December 2020

No Evidence for Linkage at Candidate Type 2 Diabetes Susceptibility Loci on Chromosomes 12 and 20 in United Kingdom Caucasians

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12 December 2020

Increasing the power and efficiency of disease-marker case-control association studies through use of allele-sharing information

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12 December 2020

E23K single nucleotide polymorphism in the islet ATP-sensitive potassium channel gene (Kir6.2) contributes as much to the risk of Type II diabetes in Caucasians as the PPARgamma Pro12Ala variant.

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12 December 2020

The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits

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12 December 2020

High-throughput screening for evidence of association by using mass spectrometry genotyping on DNA pools

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12 December 2020

A missense mutation in hepatocyte nuclear factor-4 alpha, resulting in a reduced transactivation activity, in human late-onset non-insulin-dependent diabetes mellitus

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12 December 2020

A transcription factor regulatory circuit in differentiated pancreatic cells

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12 December 2020

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

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12 December 2020

A comprehensive review of genetic association studies

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12 December 2020

A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young

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12 December 2020

The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes

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12 December 2020

Genetics of gene expression surveyed in maize, mouse and man

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12 December 2020

Genome scan for human obesity and linkage to markers in 20q13.

1 reference

12 December 2020

Are variants in the CAPN10 gene related to risk of type 2 diabetes? A quantitative assessment of population and family-based association studies

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12 December 2020

Growing evidence for diabetes susceptibility genes from genome scan data

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12 December 2020

Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action

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12 December 2020

Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q.

1 reference

12 December 2020

Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function

1 reference

12 December 2020

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

1 reference

12 December 2020

A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20

1 reference

12 December 2020

Further evidence for a susceptibility locus for type 2 diabetes on chromosome 20q13.1-q13.2.

1 reference

12 December 2020

Studies of the genetic variability of the coding region of the hepatocyte nuclear factor-4alpha in Caucasians with maturity onset NIDDM

1 reference

12 December 2020

Rare variants identified in the HNF-4α β-cell-specific promoter and alternative exon 1 lack biological significance in maturity onset diabetes of the young and young onset Type II diabetes

1 reference

12 December 2020

Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24.

1 reference

12 December 2020

Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p

1 reference

12 December 2020

Genome-wide and fine-mapping linkage studies of type 2 diabetes and glucose traits in the Old Order Amish: evidence for a new diabetes locus on chromosome 14q11 and confirmation of a locus on chromosome 1q21-q24.

1 reference

12 December 2020

Exclusion of the hepatocyte nuclear factor 4alpha as a candidate gene for late-onset NIDDM linked with chromosome 20q.

1 reference

12 December 2020

A Genome-Wide Search for Type 2 Diabetes Susceptibility Genes in West Africans: The Africa America Diabetes Mellitus (AADM) Study

1 reference

12 December 2020

A genome-wide search for type II diabetes susceptibility genes in Chinese Hans

1 reference

12 December 2020

Searching for Type 2 Diabetes Genes on Chromosome 20

1 reference

12 December 2020

Mapping genes influencing type 2 diabetes risk and BMI in Japanese subjects

1 reference

12 December 2020

A major locus for fasting insulin concentrations and insulin resistance on chromosome 6q with strong pleiotropic effects on obesity-related phenotypes in nondiabetic Mexican Americans

1 reference

12 December 2020

Control of pancreas and liver gene expression by HNF transcription factors

1 reference

12 December 2020

Association of protein tyrosine phosphatase 1B gene polymorphisms with type 2 diabetes

1 reference

12 December 2020

A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an ashkenazi jewish population.

1 reference

12 December 2020

A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene

1 reference

12 December 2020

Association of protein tyrosine phosphatase 1B gene polymorphisms with measures of glucose homeostasis in Hispanic Americans: the insulin resistance atherosclerosis study (IRAS) family study

1 reference

12 December 2020

Organization and partial sequence of the hepatocyte nuclear factor-4 alpha/MODY1 gene and identification of a missense mutation, R127W, in a Japanese family with MODY

1 reference

12 December 2020

Functional characterization of the MODY1 gene mutations HNF4(R127W), HNF4(V255M), and HNF4(E276Q).

1 reference

12 December 2020

Analysis of the HNF4 alpha gene in Caucasian type II diabetic nephropathic patients

1 reference

12 December 2020

Quantitative trait linkage studies of diabetes-related traits

1 reference

12 December 2020

New susceptibility locus for NIDDM is localized to human chromosome 20q

1 reference

12 December 2020

Autosomal genomic scan for loci linked to obesity and energy metabolism in Pima Indians

1 reference

12 December 2020

Common Variants of the Hepatocyte Nuclear Factor-4 P2 Promoter Are Associated With Type 2 Diabetes in the U.K. Population

1 reference

12 December 2020

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

1 reference

12 December 2020

A Genome Scan for Type 2 Diabetes Susceptibility Loci in a Genetically Isolated Population

1 reference

12 December 2020

Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes

1 reference

12 December 2020

Naturally occurring mutations in the human HNF4alpha gene impair the function of the transcription factor to a varying degree

1 reference

12 December 2020

Linkage of body mass index to chromosome 20 in Utah pedigrees.

1 reference

12 December 2020

Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians

1 reference

12 December 2020

Expression of the alpha7 isoform of hepatocyte nuclear factor (HNF) 4 is activated by HNF6/OC-2 and HNF1 and repressed by HNF4alpha1 in the liver

1 reference

12 December 2020

Replication validity of genetic association studies

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12 December 2020

Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility

1 reference

12 December 2020

A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q

1 reference

12 December 2020

Regulation of Pancreatic .BETA.-cell Function by the HNF Transcription Network: Lessons from Maturity-Onset Diabetes of the Young (MODY)

1 reference

12 December 2020

Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs

1 reference

12 December 2020

Single nucleotide polymorphisms in protein tyrosine phosphatase 1beta (PTPN1) are associated with essential hypertension and obesity

1 reference

12 December 2020

Genome scans provide evidence for low-HDL-C loci on chromosomes 8q23, 16q24.1-24.2, and 20q13.11 in Finnish families

1 reference

12 December 2020

A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14

1 reference

12 December 2020

T130I mutation in HNF-4alpha gene is a loss-of-function mutation in hepatocytes and is associated with late-onset Type 2 diabetes mellitus in Japanese subjects

1 reference

12 December 2020

Genotype/phenotype relationships in HNF-4alpha/MODY1: haploinsufficiency is associated with reduced apolipoprotein (AII), apolipoprotein (CIII), lipoprotein(a), and triglyceride levels

1 reference

12 December 2020

The International HapMap Project

1 reference

12 December 2020

Polymorphisms in both promoters of hepatocyte nuclear factor 4-alpha are associated with type 2 diabetes in the Amish

1 reference

12 December 2020

Molecular etiologies of MODY and other early-onset forms of diabetes

1 reference

12 December 2020

Linkage of genetic markers on human chromosomes 20 and 12 to NIDDM in Caucasian sib pairs with a history of diabetic nephropathy

1 reference

12 December 2020

Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region

1 reference

12 December 2020

Genome-wide scan on plasma triglyceride and high density lipoprotein cholesterol levels, accounting for the effects of correlated quantitative phenotypes

1 reference

12 December 2020