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β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer's disease
scientific article (publication date: 2014)
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scholarly article
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title
β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer's disease
(English)
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main subject
Alzheimer's disease
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based on heuristic
inferred from title
author name string
Kelly Willemijn Menting
series ordinal
1
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Jurgen A H R Claassen
series ordinal
2
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language of work or name
English
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publication date
2014
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published in
Frontiers in Aging Neuroscience
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216330
volume
6
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page(s)
165
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cites work
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Control of peripheral nerve myelination by the beta-secretase BACE1
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NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo
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20 March 2017
Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3
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BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics
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Expression analysis of BACE2 in brain and peripheral tissues
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Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein
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Purification and cloning of amyloid precursor protein beta-secretase from human brain
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20 March 2017
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
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PubMed Central
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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
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20 March 2017
Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase
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6 April 2017
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
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7 April 2017
CNS amyloid-β, soluble APP-α and -β kinetics during BACE inhibition.
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29 September 2017
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons
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The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo
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29 September 2017
The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb
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29 September 2017
Developing β-secretase inhibitors for treatment of Alzheimer's disease
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29 September 2017
The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease
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29 September 2017
Inhibition of BACE1 for therapeutic use in Alzheimer's disease
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29 September 2017
Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial
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29 September 2017
The Alzheimer's disease beta-secretase enzyme, BACE1.
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Filling the gaps in the abeta cascade hypothesis of Alzheimer's disease
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Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease
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29 September 2017
BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome
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BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.
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29 September 2017
Beta-secretase inhibition for the treatment of Alzheimer's disease--promise and challenge
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Aspartic peptidase inhibitors: implications in drug development
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29 September 2017
BACE1 is the major beta-secretase for generation of Abeta peptides by neurons
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104928
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29 September 2017
Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104928
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29 September 2017
A splice variant of beta-secretase deficient in the amyloidogenic processing of the amyloid precursor protein
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104928
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29 September 2017
Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease
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PubMed Central
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29 September 2017
Targeting HIV-1 protease: a test of drug-design methodologies
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29 September 2017
The molecular pathology of Alzheimer's disease
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PubMed Central
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29 September 2017
Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production
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29 September 2017
Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles
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PubMed Central
reference URL
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2 June 2018
Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains.
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2 June 2018
Bace1 modulates myelination in the central and peripheral nervous system.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104928
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27 November 2018
BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease
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PubMed Central
reference URL
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27 November 2018
Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104928
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27 November 2018
Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease
1 reference
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PubMed Central
reference URL
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27 November 2018
Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.
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PubMed Central
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27 November 2018
Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase)
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25100992
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.3389/FNAGI.2014.00165
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2394509
OpenCitations bibliographic resource ID
2394509
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2394509
PMC publication ID
4104928
0 references
PubMed publication ID
25100992
0 references
ResearchGate publication ID
264640057
0 references
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