(Q28246519)

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Cyclic AMP-dependent protein kinase phosphorylates merlin at serine 518 independently of p21-activated kinase and promotes merlin-ezrin heterodimerization

scientific article (publication date: 30 April 2004)

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scholarly article

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24 November 2019

Cyclic AMP-dependent protein kinase phosphorylates merlin at serine 518 independently of p21-activated kinase and promotes merlin-ezrin heterodimerization (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14981079%20AND%20SRC:MED&resulttype=core&format=json

24 November 2019

phosphorylation

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protein heterodimerization activity

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based on heuristic

inferred from title

Mikaela Grönholm

3

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24 November 2019

4

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24 November 2019

author name string

Kaija Alfthan

1

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24 November 2019

Leena Heiska

2

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24 November 2019

Olli Carpén

5

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publication date

23 February 2004

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24 November 2019

Journal of Biological Chemistry

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24 November 2019

279

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18

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24 November 2019

18559-18566

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24 November 2019

Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Hierarchy of merlin and ezrin N- and C-terminal domain interactions in homo- and heterotypic associations and their relationship to binding of scaffolding proteins EBP50 and E3KARP.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

ERM proteins and merlin: integrators at the cell cortex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Regulation of the neurofibromatosis type 2 tumor suppressor protein, merlin, by adhesion and growth arrest stimuli

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

p21-activated kinase links Rac/Cdc42 signaling to merlin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Merlin, the Product of the Nf2 Tumor Suppressor Gene, Is an Inhibitor of the p21-Activated Kinase, Pak1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

PKA isoforms, neural pathways, and behaviour: making the connection

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Cognitive neuroscience

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Characterization of protein kinase A-mediated phosphorylation of ezrin in gastric parietal cell activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

AKAPs: from structure to function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

A-kinase anchoring proteins: protein kinase A and beyond

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

The biological functions of A-kinase anchor proteins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Merlin links to the cAMP neuronal signaling pathway by anchoring the RIbeta subunit of protein kinase A.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

pEF-BOS, a powerful mammalian expression vector

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Ezrin contains cytoskeleton and membrane binding domains accounting for its proposed role as a membrane-cytoskeletal linker

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Specificity and mechanism of action of some commonly used protein kinase inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Physiological substrates of cAMP-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Merlin and ERM proteins: unappreciated roles in cancer development?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Ezrin is a cyclic AMP-dependent protein kinase anchoring protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Localization and characterization of the binding site for the regulatory subunit of type II cAMP-dependent protein kinase on MAP2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Phosphorylation-dependent localization of microtubule-associated protein MAP2c to the actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Phosphorylation-regulated Inhibition of the Gz GTPase-activating Protein Activity of RGS Proteins by Synapsin I

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

CD44: from adhesion molecules to signalling regulators

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Isolation and characterization of Schwann cells from neurofibromatosis type 2 patients

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

The neurofibromatosis type 2 gene product, merlin, reverses the F-actin cytoskeletal defects in primary human Schwannoma cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Interdomain binding mediates tumor growth suppression by the NF2 gene product

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Interdomain interaction of merlin isoforms and its influence on intermolecular binding to NHE-RF

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Protein kinase C-theta phosphorylation of moesin in the actin-binding sequence

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

cAMP-dependent protein kinase A is required for Schwann cell growth: interactions between the cAMP and neuregulin/tyrosine kinase pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313916200

21 January 2018

Identifiers

10.1074/JBC.M313916200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14981079%20AND%20SRC:MED&resulttype=core&format=json

24 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14981079%20AND%20SRC:MED&resulttype=core&format=json

24 November 2019

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