(Q28253557)

2

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Raymond Schlienger

3

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Jürgen Drewe

4

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Stephan Krähenbühl

Pharmacokinetics of midazolam following intravenous and oral administration in patients with chronic liver disease and in healthy subjects.

5

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language of work or name

English

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publication date

2005

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published in

Drug Safety

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volume

28

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issue

6

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page(s)

529-45

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cites work

1 reference

12 December 2020

Creatinine clearance: an inadequate marker of renal filtration in patients with early posthepatitic cirrhosis (Child A) without fluid retention and muscle wasting

1 reference

12 December 2020

The pharmacokinetics of vincristine in man: reduced drug clearance associated with raised serum alkaline phosphatase and dose-limited elimination

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12 December 2020

Glomerular filtration rate measurement in cirrhotic patients with renal failure

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12 December 2020

Pharmacokinetics of zidovudine in patients with liver cirrhosis

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12 December 2020

Steady-state extrarenal sorbitol clearance as a measure of hepatic plasma flow

1 reference

12 December 2020

Pharmacokinetics of chlormethiazole in healthy volunteers and patients with cirrhosis of the liver

1 reference

12 December 2020

Cimetidine administration and tubular creatinine secretion in patients with compensated cirrhosis

1 reference

12 December 2020

Nisoldipine: kinetics and effects on blood pressure and heart rate in patients with liver cirrhosis after intravenous and oral administration

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12 December 2020

Different alterations of cytochrome P450 3A4 isoform and its gene expression in livers of patients with chronic liver diseases

1 reference

12 December 2020

Furosemide kinetics and dynamics in patients with cirrhosis

1 reference

12 December 2020

HLA association of amoxicillin-clavulanate--induced hepatitis

1 reference

12 December 2020

Clinical efficacy and toxicity of standard dose adriamycin in hyperbilirubinaemic patients with hepatocellular carcinoma: relation to liver tests and pharmacokinetic parameters

1 reference

12 December 2020

Pharmacokinetics of ceftazidime in patients with liver cirrhosis and ascites

1 reference

12 December 2020

The effects of impaired liver function on the elimination of antineoplastic agents

1 reference

12 December 2020

Etoposide kinetics in patients with obstructive jaundice

1 reference

12 December 2020

Interaction between grapefruit juice and midazolam in humans.

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of torasemide and furosemide in patients with diuretic resistant ascites

1 reference

12 December 2020

Epirubicin in breast cancer patients with liver metastases and abnormal liver biochemistry: Initial weekly treatment followed by rescheduling and intensification

1 reference

12 December 2020

Hepatic extraction of morphine is impaired in cirrhosis

1 reference

12 December 2020

Clinical pharmacokinetics of vinorelbine

1 reference

12 December 2020

Effects of the benzodiazepine receptor antagonist flumazenil in hepatic encephalopathy in humans.

1 reference

12 December 2020

Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults.

1 reference

12 December 2020

Leaky gut in alcoholic cirrhosis: a possible mechanism for alcohol-induced liver damage

1 reference

12 December 2020

The metabolism and bioavailability of morphine in patients with severe liver cirrhosis

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of intravenous midazolam in patients with severe alcoholic cirrhosis

1 reference

12 December 2020

Unpredictability of clinical evaluation of renal function in cirrhosis. Prospective study

1 reference

12 December 2020

The pharmacokinetics and pharmacodynamics of the diuretic bumetanide in hepatic and renal disease

1 reference

12 December 2020

Pharmacotherapy of ascites associated with cirrhosis

1 reference

12 December 2020

Tubular sodium handling in cirrhotic patients with ascites as analysed by the renal lithium clearance method

1 reference

12 December 2020

Differential alterations of cytochrome P450 proteins in livers from patients with severe chronic liver disease

1 reference

12 December 2020

Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease.

1 reference

12 December 2020

CYP2E1 mediated isoniazid-induced hepatotoxicity in rats

1 reference

12 December 2020

Portal Hypertensive gastropathy

1 reference

12 December 2020

Role of portal and splenic vein shunts and impaired hepatic extraction in the elevated serum bile acids in liver cirrhosis.

1 reference

12 December 2020

Pharmacokinetics of diazepam in disordered liver function

1 reference

12 December 2020

Influence of hepatic cirrhosis and end-stage renal disease on pharmacokinetics and pharmacodynamics of furosemide

1 reference

12 December 2020

Oral pharmacokinetics and ascitic fluid penetration of ofloxacin in cirrhosis

1 reference

12 December 2020

Downregulation of hepatic cytochrome P450 in chronic renal failure.

1 reference

12 December 2020

Glucuronidation of drugs by hepatic microsomes derived from healthy and cirrhotic human livers

1 reference

12 December 2020

Single-dose pharmacokinetics of fluconazole in patients with liver cirrhosis

1 reference

12 December 2020

Selective reduction of hepatic cytochrome P450 content in patients with intrahepatic cholestasis. A mechanism for impairment of microsomal drug oxidation

1 reference

12 December 2020

Hepatitis after intravenous buprenorphine misuse in heroin addicts

1 reference

12 December 2020

Renal functional reserve and nitric oxide in patients with compensated liver cirrhosis

1 reference

12 December 2020

Selective inhibition of cyclooxygenase 2 spares renal function and prostaglandin synthesis in cirrhotic rats with ascites

1 reference

12 December 2020

Pharmacokinetics of cefprozil in healthy subjects and patients with hepatic impairment

1 reference

12 December 2020

HLA class II genotype influences the type of liver injury in drug-induced idiosyncratic liver disease

1 reference

12 December 2020

Breath 14CO2 after intravenous administration of [14C]aminopyrine in liver diseases

1 reference

12 December 2020

Effect of hepatic insufficiency on pharmacokinetics and drug dosing

1 reference

12 December 2020

Triazolam in cirrhosis: pharmacokinetics and pharmacodynamics

1 reference

12 December 2020

Enhanced bioavailability and decreased clearance of analgesics in patients with cirrhosis

1 reference

12 December 2020

Pharmacokinetics of unchanged morphine in normal and cirrhotic subjects.

1 reference

12 December 2020

Identification of patients with impaired hepatic drug metabolism using a limited sampling procedure for estimation of phenazone (antipyrine) pharmacokinetic parameters.

1 reference

12 December 2020

Anti-tuberculosis medication and the liver: dangers and recommendations in management

1 reference

12 December 2020

Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients

1 reference

12 December 2020

Pharmacokinetics and protein binding of cefpiramide in patients with alcoholic cirrhosis

1 reference

12 December 2020

Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity

1 reference

12 December 2020

Plasma and hepatic carnitine and coenzyme A pools in a patient with fatal, valproate induced hepatotoxicity

1 reference

12 December 2020

Both phenolic and acyl glucuronidation pathways of diflunisal are impaired in liver cirrhosis

1 reference

12 December 2020

Decreased first-pass metabolism of labetalol in chronic liver disease

1 reference

12 December 2020

Hepatic encephalopathy in liver cirrhosis: pathogenesis, diagnosis and management

1 reference

12 December 2020

Hepatic clearance and liver blood flow

1 reference

12 December 2020

Pharmacokinetics of oral mycophenolate mofetil in volunteer subjects with varying degrees of hepatic oxidative impairment

1 reference

12 December 2020

Oral Disposition Kinetics of Ofloxacin in Patients with Compensated Liver Cirrhosis

1 reference

12 December 2020

Lidocaine metabolite formation as a measure of liver function in patients with cirrhosis.

1 reference

12 December 2020

Abnormal gastric motility in liver cirrhosis: roles of secretin

1 reference

12 December 2020

Prediction of creatinine clearance from serum creatinine

1 reference

12 December 2020

Fulminant hepatic failure associated with benzbromarone treatment: a case report

1 reference

12 December 2020

D-propoxyphene and norpropoxyphene kinetics after the oral administration of D-propoxyphene: a new approach to liver function?

1 reference

12 December 2020

Low serum creatinine levels in severe hepatic disease

1 reference

12 December 2020

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

1 reference

12 December 2020

Transection of the oesophagus for bleeding oesophageal varices

1 reference

12 December 2020

Methotrexate and histologic hepatic abnormalities: a meta-analysis

1 reference

12 December 2020

Bioavailability, pharmacokinetics, and pharmacodynamics of torsemide in patients with cirrhosis

1 reference

12 December 2020

The effects of age and chronic liver disease on the elimination of temazepam

1 reference

12 December 2020

Pharmacokinetics, bioavailability and ECG response of verapamil in patients with liver cirrhosis

1 reference

12 December 2020

Relationship among gastric motility, autonomic activity, and portal hemodynamics in patients with liver cirrhosis

1 reference

12 December 2020

Hemodynamic and pharmacokinetic study of propranolol and atenolol in cirrhosis patients

1 reference

12 December 2020

Influence of cirrhosis on lamotrigine pharmacokinetics

1 reference

12 December 2020

Renal effects of selective cyclooxygenase-2 inhibition in normotensive salt-depleted subjects

1 reference

12 December 2020

The effects of age and liver disease on the disposition and elimination of diazepam in adult man

1 reference

12 December 2020

Normal metabolism of morphine in cirrhosis

1 reference

12 December 2020

A study to survey susceptible genetic factors responsible for troglitazone‐associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus

1 reference

12 December 2020

Pharmacokinetics of opioids in liver disease

1 reference

12 December 2020

Comparison of in vitro and in vivo biotransformation in patients with liver disease of differing severity

1 reference

12 December 2020

Delayed gastric emptying in patients with liver cirrhosis

1 reference

12 December 2020

Association of troglitazone-induced liver injury with mutation of the cytochrome P450 2C19 gene

1 reference

12 December 2020

Nifedipine: kinetics and hemodynamic effects in patients with liver cirrhosis after intravenous and oral administration

1 reference

12 December 2020

Effects of cisapride on abnormally prolonged endogastric alkalinity time and delayed gastric emptying in cirrhotic patients

1 reference

12 December 2020

Renal dysfunction in liver cirrhosis: renal duplex Doppler US vs. scintigraphy for early identification

1 reference

12 December 2020

Assessment of portal hemodynamics by ultrasound color Doppler and laser Doppler velocimetry in liver cirrhosis.

1 reference

12 December 2020

Repeated diazepam dosing in cirrhotic patients: cumulation and sedation.

1 reference

12 December 2020

Clinical pharmacokinetics and pharmacodynamics of torasemide

1 reference

12 December 2020

The complex interaction between ethanol and acetaminophen

1 reference

12 December 2020

Nitric oxide as a mediator of hemodynamic abnormalities and sodium and water retention in cirrhosis.

1 reference

12 December 2020

Principles of drug administration in renal insufficiency

1 reference

12 December 2020

Evaluation of measured and calculated creatinine clearances as glomerular filtration markers in different stages of liver cirrhosis

1 reference

12 December 2020

Assessment of hepatic blood flow in healthy subjects by continuous infusion of indocyanine green

1 reference

12 December 2020

Selective effect of liver disease on the activities of specific metabolizing enzymes: investigation of cytochromes P450 2C19 and 2D6.

1 reference

12 December 2020

Tubular site of renal sodium retention in ascitic liver cirrhosis evaluated by lithium clearance

1 reference

12 December 2020

Morphine tolerance in hepatic cirrhosis

1 reference

12 December 2020

Pharmacokinetic changes in patients with oedema.

1 reference

12 December 2020

Flumazenil disposition and elimination in cirrhosis

1 reference

12 December 2020

Angiotensin-converting enzyme (ACE)-inhibition in cirrhosis. Pharmacokinetics and dynamics of the ACE-inhibitor cilazapril (Ro 31-2848)

1 reference

12 December 2020

Peptic ulcer and its course in cirrhosis: an endoscopic and clinical prospective study.

1 reference

12 December 2020

Mitochondrial diseases represent a risk factor for valproate-induced fulminant liver failure

1 reference

12 December 2020

Gastric emptying in patients with chronic liver diseases

1 reference

12 December 2020

Plasma levels and urinary excretion of lormetazepam in patients with liver cirrhosis and in healthy volunteers

1 reference

12 December 2020

Clinical effects and metabolism of diazepam in patients with chronic liver disease.

1 reference

12 December 2020

Impaired mitochondrial function in microvesicular steatosis. Effects of drugs, ethanol, hormones and cytokines

1 reference

12 December 2020

Pre-translational regulation of cytochrome P450 genes is responsible for disease-specific changes of individual P450 enzymes among patients with cirrhosis.

1 reference

12 December 2020

Erythromycin intravenous bolus infusion in acute upper gastrointestinal bleeding: a randomized, controlled, double-blind trial

1 reference

12 December 2020

Carnitine metabolism in patients with chronic liver disease

1 reference

12 December 2020

Diagnostic value of plasma cystatin C as a glomerular filtration marker in decompensated liver cirrhosis

1 reference

12 December 2020

Limitations of serum creatinine level and creatinine clearance as filtration markers in cirrhosis

1 reference

12 December 2020

Gastric secretion and peptic ulceration in cirrhosis

1 reference

12 December 2020

Predisposing factors in hepatitis induced by isoniazid-rifampin treatment of tuberculosis

1 reference

12 December 2020

Clinical pharmacokinetic and pharmacodynamic considerations in patients with liver disease. An update

1 reference

12 December 2020

Caffeine: a model compound for measuring liver function.

1 reference

12 December 2020

Encainide disposition in patients with chronic cirrhosis

1 reference

12 December 2020

The erythromycin breath test as a predictor of cyclosporine blood levels.

1 reference

12 December 2020

The pharmacokinetics of single doses of metoclopramide in renal failure

1 reference

12 December 2020

Drug metabolism in end-stage liver disease. In vitro activities of some phase I and phase II enzymes

1 reference

12 December 2020

Furosemide disposition in cirrhotic patients

1 reference

12 December 2020

Renal function in compensated hepatic cirrhosis: effects of an amino acid infusion and relationship with nitric acid

1 reference

12 December 2020

Normal disposition of oxazepam in acute viral hepatitis and cirrhosis

1 reference

12 December 2020

The Effect of Renal Failure on Hepatic Drug Clearance

1 reference

12 December 2020