(Q28264693)

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Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22510516%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22510516%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Erb-b2 receptor tyrosine kinase 2

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Herbert Kim Lyerly

7

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22510516%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

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Leonard M Neckers

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29 January 2020

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Qing Cheng

1

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29 January 2020

Jeffrey T Chang

2

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29 January 2020

Joseph Geradts

3

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29 January 2020

Timothy Haystead

5

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29 January 2020

Neil L Spector

6

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29 January 2020

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17 April 2012

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29 January 2020

Breast Cancer Research

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22510516%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

14

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29 January 2020

2

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29 January 2020

R62

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29 January 2020

Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells

1 reference

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20 March 2017

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1 reference

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20 March 2017

Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90

1 reference

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20 March 2017

Targeting the dynamic HSP90 complex in cancer

1 reference

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20 March 2017

Cancer statistics, 2010

1 reference

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20 March 2017

Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer

1 reference

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20 March 2017

Genes that mediate breast cancer metastasis to the brain

1 reference

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20 March 2017

Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target

1 reference

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20 March 2017

Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

20 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

6 April 2017

Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

20 March 2017

Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

20 March 2017

The HSP90 family of genes in the human genome: insights into their divergence and evolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

20 March 2017

Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

20 March 2017

The landscape of somatic copy-number alteration across human cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

7 April 2017

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

7 April 2017

PennCNV: an integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

7 April 2017

Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

7 April 2017

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

7 April 2017

Effective targeting of triple-negative breast cancer cells by PF-4942847, a novel oral inhibitor of Hsp 90.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

29 September 2017

Why is this effective HSP90 inhibitor not being developed in HER2+ breast cancer?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

29 September 2017

Importance of pre-analytical steps for transcriptome and RT-qPCR analyses in the context of the phase II randomised multicentre trial REMAGUS02 of neoadjuvant chemotherapy in breast cancer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

29 September 2017

Linear and non-linear dependencies between copy number aberrations and mRNA expression reveal distinct molecular pathways in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

29 September 2017

Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

29 September 2017

High-resolution comparative genomic hybridization of inflammatory breast cancer and identification of candidate genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

29 September 2017

High-Dimensional Sparse Factor Modeling: Applications in Gene Expression Genomics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

29 September 2017

Gene pathways associated with prognosis and chemotherapy sensitivity in molecular subtypes of breast cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

29 September 2017

An integrated approach to uncover drivers of cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

29 September 2017

Integrative functional genomics analysis of sustained polyploidy phenotypes in breast cancer cells identifies an oncogenic profile for GINS2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

29 September 2017

Genome profiling of ERBB2-amplified breast cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

29 September 2017

Genomic index of sensitivity to endocrine therapy for breast cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

29 September 2017

Hsp90 in the continuum of breast ductal carcinogenesis: Evaluation in precursors, preinvasive and ductal carcinoma lesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

29 September 2017

A gene expression signature identifies two prognostic subgroups of basal breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

29 September 2017

PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

29 September 2017

Potential prognostic value of heat-shock protein 90 in the presence of phosphatidylinositol-3-kinase overexpression or loss of PTEN, in invasive breast cancers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

29 September 2017

Assessment of an RNA interference screen-derived mitotic and ceramide pathway metagene as a predictor of response to neoadjuvant paclitaxel for primary triple-negative breast cancer: a retrospective analysis of five clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

29 September 2017

The Gene expression Grade Index: a potential predictor of relapse for endocrine-treated breast cancer patients in the BIG 1-98 trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

29 September 2017

Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

29 September 2017

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1 reference

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29 September 2017

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

1 reference

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29 September 2017

A combination of Trastuzumab and 17-AAG induces enhanced ubiquitinylation and lysosomal pathway-dependent ErbB2 degradation and cytotoxicity in ErbB2-overexpressing breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

29 September 2017

Triple-negative breast cancer: clinical features and patterns of recurrence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

29 September 2017

Lung metastasis genes couple breast tumor size and metastatic spread.

1 reference

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29 September 2017

High HSP90 expression is associated with decreased survival in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

29 September 2017

An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival

1 reference

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29 September 2017

CUTL1 is a target of TGF(beta) signaling that enhances cancer cell motility and invasiveness

1 reference

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29 September 2017

Targeting multiple signal transduction pathways through inhibition of Hsp90.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

29 September 2017

Heat shock protein 90.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

29 September 2017

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

1 reference

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Chromosome aberrations in solid tumors

1 reference

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29 September 2017

Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors

1 reference

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29 September 2017

Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446397

29 September 2017

Integrated study of copy number states and genotype calls using high-density SNP arrays

1 reference

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1 reference

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2 June 2018

Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade

1 reference

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2 June 2018

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1 reference

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2 June 2018

Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes

1 reference

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21 January 2018

HSP90 inhibition is effective in breast cancer: a phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab.

1 reference

https://api.crossref.org/works/10.1186%2FBCR3168

21 January 2018

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1 reference

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21 January 2018

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1 reference

https://api.crossref.org/works/10.1186%2FBCR3168

21 January 2018

Prediction of lymph node involvement in breast cancer from primary tumor tissue using gene expression profiling and miRNAs

1 reference

https://api.crossref.org/works/10.1186%2FBCR3168

21 January 2018

Impact of DNA amplification on gene expression patterns in breast cancer

1 reference

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27 November 2018

The humoral immune system has a key prognostic impact in node-negative breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22510516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Locoregional Relapse and Distant Metastasis in Conservatively Managed Triple Negative Early-Stage Breast Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22510516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification of the major mammalian heat shock proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/22510516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predicting features of breast cancer with gene expression patterns

1 reference

https://pubmed.ncbi.nlm.nih.gov/22510516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/BCR3168

2 references

Consolidated OpenCitations Corpus – April 2017

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22510516%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

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OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22510516%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

PubMed publication ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22510516%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

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