(Q28269238)

English

Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18285456%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein (English)

1 reference

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3 January 2020

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Randall S. Johnson

9

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3 January 2020

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Li Lei

1

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3 January 2020

Steve Mason

2

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3 January 2020

Dinggang Liu

3

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3 January 2020

Yan Huang

4

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3 January 2020

Carolyn Marks

5

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3 January 2020

Reed Hickey

6

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3 January 2020

Ion S Jovin

7

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3 January 2020

Marc Pypaert

8

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3 January 2020

Frank J Giordano

10

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3 January 2020

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19 February 2008

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3 January 2020

Molecular and Cellular Biology

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3 January 2020

28

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3 January 2020

3790-3803

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3 January 2020

11

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Europe PubMed Central

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3 January 2020

Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans

1 reference

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20 March 2017

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

1 reference

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20 March 2017

von Hippel-Lindau disease

1 reference

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20 March 2017

Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

20 March 2017

Molecular basis of the VHL hereditary cancer syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

20 March 2017

Life at the edge: the nuclear envelope and human disease

1 reference

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20 March 2017

HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

20 March 2017

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

1 reference

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20 March 2017

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

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20 March 2017

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

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20 March 2017

Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

20 March 2017

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

1 reference

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20 March 2017

Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis

1 reference

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20 March 2017

The von hippel-lindau tumor suppressor protein: an update

1 reference

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29 September 2017

Roles of mTOR and STAT3 in autophagy induced by telomere 3' overhang-specific DNA oligonucleotides

1 reference

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29 September 2017

Cardiac autophagy is a maladaptive response to hemodynamic stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

29 September 2017

Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

29 September 2017

Hypoxia-independent overexpression of hypoxia-inducible factor 1alpha as an early change in mouse hepatocarcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

29 September 2017

Human HIF-3alpha4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma

1 reference

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29 September 2017

Oxygen, oxidative stress, hypoxia, and heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

29 September 2017

Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

29 September 2017

The pathological basis of myocardial hibernation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

29 September 2017

HIF hydroxylation and the mammalian oxygen-sensing pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

29 September 2017

Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

29 September 2017

The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

29 September 2017

A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

29 September 2017

HIF-1 and mechanisms of hypoxia sensing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

29 September 2017

Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.

1 reference

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29 September 2017

Angiogenesis: the role of the microenvironment in flipping the switch.

1 reference

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29 September 2017

Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

29 September 2017

Isoforms of vascular endothelial growth factor act in a coordinate fashion To recruit and expand tumor vasculature.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

29 September 2017

The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

29 September 2017

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

29 September 2017

BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy

1 reference

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2 June 2018

Autophagocytosis of mitochondria is prominent in Alzheimer disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

2 June 2018

Allele loss and promoter hypermethylation of VHL, RAR-beta, RASSF1A, and FHIT tumor suppressor genes on chromosome 3p in esophageal squamous cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

2 June 2018

Adenoviral-directed expression of the type 1A angiotensin receptor promotes cardiomyocyte hypertrophy via transactivation of the epidermal growth factor receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

2 June 2018

Early expression of angiogenesis factors in acute myocardial ischemia and infarction

1 reference

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2 June 2018

High-efficiency, long-term cardiac expression of foreign genes in living mouse embryos and neonates.

1 reference

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2 June 2018

A post-transcriptional compensatory pathway in heterozygous ventricular myosin light chain 2-deficient mice results in lack of gene dosage effect during normal cardiac growth or hypertrophy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

2 June 2018

Survivin, cancer networks and pathway-directed drug discovery.

1 reference

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27 November 2018

Oxidative stress and Alzheimer disease: the autophagy connection?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

27 November 2018

Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

27 November 2018

Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

27 November 2018

Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

27 November 2018

Human hibernating myocardium is jeopardized by apoptotic and autophagic cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

27 November 2018

Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423296

27 November 2018

Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development.

1 reference

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27 November 2018

Susceptibility to vascular neoplasms but no increased susceptibility to renal carcinogenesis in Vhl knockout mice.

1 reference

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27 November 2018

Inhibition of zebrafish epidermal growth factor receptor activity results in cardiovascular defects

1 reference

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27 November 2018

Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis.

1 reference

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27 November 2018

Regulation of proliferation of the fetal myocardium

1 reference

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27 November 2018

Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart

1 reference

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27 November 2018

Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice.

1 reference

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27 November 2018

Therapeutic gene regulation: targeting transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/18285456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AMPK mediates autophagy during myocardial ischemia in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/18285456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adult rabbit cardiomyocytes undergo hibernation-like dedifferentiation when co-cultured with cardiac fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/18285456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comprehensive mutational analysis of the VHL gene in sporadic renal cell carcinoma: relationship to clinicopathological parameters

1 reference

https://pubmed.ncbi.nlm.nih.gov/18285456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/18285456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transforming growth factor alpha is a target for the von Hippel-Lindau tumor suppressor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18285456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of constitutively stable hybrid hypoxia-inducible factor-1alpha protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/18285456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of a constitutively active hypoxia-inducible factor-1alpha transgene as a therapeutic strategy in no-option critical limb ischemia patients: phase I dose-escalation experience

1 reference

https://pubmed.ncbi.nlm.nih.gov/18285456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.01580-07

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18285456%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18285456%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18285456%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

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